Organ: Body weight ratios for certain organs of laboratory animals. II. Guinea pig

Webster, Stewart H.; Liljegren, Ervin J.

doi:10.1002/aja.1000850203

Cited by 24 publications

(7 citation statements)

References 12 publications

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“…Results gathered herein clearly deviate from these findings. The exponent found by Webster and Liljegren [20] was included in the 95% confidence interval of the slim animals; even though the scaling exponent for liver mass did not differ significantly between slim and obese animals in the present study (due to overlapping 95% confidence intervals), the scaling was steeper in the obese specimens, suggesting that the overall extreme scaling in animals derived from a pathological condition of the liver due to fasting that was particularly pronounced in this group.…”

Section: Liver Mass To Body Masscontrasting

confidence: 62%

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Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs

et al. 2020

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Background Ketosis is a metabolic disorder often triggered by anorexia in animals fed on high energy diets. Although mostly described in pregnant female guinea pigs, under the name of pregnancy toxicosis; there is limited information on ketosis in males and non-pregnant females, often presented to clinics with anorexia or inappetence. The objective of this study was to observe progression of ketosis in guinea pigs, document the changes and evaluate diagnostic methods and a therapeutic approach. Results Twenty eight adult guinea pigs (Cavia porcellus), castrated males and intact females of obese and slim body condition were fasted for 3 days and refed afterwards. The slim animals served as control group for body condition. Either slim and fat animals were divided into two treatment groups: half of them received fluid replacements with glucose subcutaneously, the other half did not receive any injection and served as treatment control. Serum beta-hydroxybutyrate, and urine acetoacetate and acetone were measured during and after fasting. Serum ALT, bile acids and liver histology were also analyzed after 7 days of refeeding (and therapy). Females and obese guinea pigs showed a significantly higher increase in ketone bodies in serum and urine. Obese, female, or animals not receiving therapy needed more time to regulate ketone bodies to normal levels than slim animals, males or animals receiving therapy. Liver histology revealed increased hepatocyte degeneration and higher glycogen content in obese animals and animals receiving therapy, and additionally more glycogen content in males. Only minor hepatic fat accumulation was documented. Bile acids showed good correlation to histological liver changes whereas ALT did not. Conclusions Female and obese animals react more intensively to fasting. As preventive management, animals should be kept in adequate body condition, fasting should be avoided, and anorexia should be treated immediately. In such a case, urinary dip sticks to detect ketone bodies are a useful diagnostic tool. Glucose therapy leads to faster cessation of ketogenesis and should be recommended in cases of ketosis. However, it needs to be adjusted to avoid hepatocyte glycogen overload and degeneration. Measuring bile acids presents a valuable indicator of liver damage.

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Section: Liver Mass To Body Masscontrasting

confidence: 62%

“…The liver mass in comparison to body mass has an unusual scaling of y = 0.0003 × 1.66 . Normal liver mass to body mass was described by Webster and Liljegren [20], where they measured different organs of guinea pigs. The trendline of their values shows a gradient of y = 0.0739 × 0.87 (Fig.…”

Section: Liver Mass To Body Massmentioning

confidence: 99%

Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs

et al. 2020

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“…Reported relative heart weights in the guinea pig range from 0.39-0.51% at birth to 0.19-0.23% in adults, with decreasing relative fraction of right ventricular weight from 57-55% of the left ventricle (Webster and Liljegren, 1949;Lee et al, 1975).…”

Section: Comparative Speciesmentioning

confidence: 99%

Postnatal anatomical and functional development of the heart: A species comparison

Hew

Keller²

2003

Birth Defects Research Pt B

121

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“…Furthermore, data of Webster and Liljegren (1949) and Fremming and coworkers (1955) show that in normal mammals an inverse relationship exists between body weight and relative weight of several organs, including the liver, heart and kidneys. This effect is not considered a specific one.…”

Section: Discussionmentioning

confidence: 99%

A Hematologic-Pathologic Study in Chickens Fed Graded Levels of Nicarbazin

et al. 1958

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Organ: Body weight ratios for certain organs of laboratory animals. II. Guinea pig

Cited by 24 publications

References 12 publications

Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs

Development, diagnosis and therapy of ketosis in non-gravid and non-lactating Guinea pigs

Postnatal anatomical and functional development of the heart: A species comparison

A Hematologic-Pathologic Study in Chickens Fed Graded Levels of Nicarbazin

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