Organ donation in trauma victims: A systematic review and meta-analysis

Cameron, Adam; Erdoğan, Mete; Lanteigne, Sara; Hetherington, Alexandra; Green, Robert S.

doi:10.1097/ta.0000000000001886

Cited by 9 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Donation after cardiac death (DCD) and the Expanded Criteria Donors permit harvesting of organs that may have been previously discarded and are now routinely utilized [14][15][16]. The interaction between these two epidemiological shifts was examined in two recent systematic reviews published in the Journal of Trauma and Acute Care Surgery [4,5]. Trauma Donors seem to be younger and with fewer comorbidities compared to NTDs.…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review proposed by Cameron et al [5] examined factors associated with organ donation. Of 27 studies included in the analysis, the effect of various factors on OD was examined in six studies, among which three used multivariable logistic regression.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, recent studies show that trauma donors (TDs) are younger, have fewer comorbidities compared to non-traumatic donors (NTDs) and produce more organs/donor (3.5 vs. 2.4) [4]. Moreover, TDs are more likely to yield an extrarenal organ and exhibit lower (better) Kidney Donor Risk Index scores, a predictor of graft longevity [5]. Unfortunately, the proportion of TDs has significantly decreased from 55.3% in 1987 to 35.8% in 2016 [6].…”

Section: Introduction 1organ Procurement After Damage Control Resusci...mentioning

confidence: 99%

See 2 more Smart Citations

Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy

Altomare

Bekhor

Cioffi

et al. 2022

Life

View full text Add to dashboard Cite

Background: Organ donation (OD) remains the only therapeutic option for end-stage disease in some cases. Unfortunately, the gap between donors and recipients is still substantial. Trauma patients represent a potential yet underestimated pool of organ donors. In this article, we present our data on OD after damage control strategy (DCS). Materials and Methods: A retrospective, observational cohort study was conducted through a complete revision of data of consecutive adult trauma patients (>18 years old) who underwent OD after DCS between January 2018 and May 2021. Four subgroups were created [Liver (Li), Lungs (Lu), Heart (H), Kidneys (K)] to compare variables between those who donated the organ of interest and those who did not. Results: Thirty-six patients underwent OD after DCS. Six patients (16.7%) were excluded: 2(5.6%) for missing data about admission; 4(11.1%) didn’t receive DCS. Mean ISS was 47.2 (SD ± 17.4). Number of donated organs was 113 with an organs/patient ratio of 3.8. The functional response rate was 91.2%. Ten organs (8.8%) had primary nonfunction after transplantation: 2/15 hearts (13.3%), 1/28 livers (3.6%), 4/53 kidneys (7.5%) and 3/5 pancreases (60%). No lung primary nonfunction were registered. Complete results of subgroup analysis are reported in supplementary materials. Conclusion: Organ donation should be considered a possible outcome in any trauma patient. Aggressive damage control strategy doesn’t affect the functional response rate of transplanted organs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introduction 1organ Procurement After Damage Control Resusci...mentioning

confidence: 99%

See 1 more Smart Citation

Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy

Altomare

Bekhor

Cioffi

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

“…Unser RR identifizierte 2 Leitlinien [ 764 , 765 ], 10 SR [ 766 – 775 ], 17 Beobachtungsstudien [ 449 , 570 , 776 – 789 ] und viele Beiträge mit indirekten Evidenzen (Anhang RR 34).…”

Section: Evidenzen Für Die Leitlinienunclassified

Lebensrettende Maßnahmen bei Kindern (Paediatric Life Support, PLS)

Voorde

Turner

Djakow

et al. 2021

Notfall Rettungsmed

View full text Add to dashboard Cite

Die Leitlinien des European Resuscitation Council (ERC) zu den lebensrettenden Maßnahmen bei Kindern (Paediatric Life Support, PLS) basieren auf dem 2020 verfassten „International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations“ der ILCOR (International Liaison Committee on Resuscitation). Dieses Kapitel beinhaltet Leitlinien zur Behandlung kritisch kranker oder verletzter Säuglinge, von Kindern und Jugendlichen vor, während und nach einem Atem-Kreislauf-Stillstand.

show abstract

“…Previous systematic reviews have investigated organ donation from the intensive care unit (ICU) exclusively, or pooled organ donation from the ED and ICU together. [8][9][10] There may be ED-specific factors that could impact organ donation. The purpose of this study is to determine what percent of successful donors come from the ED, whether there are any missed or potential donors, and what factors impact organ donation in the ED.…”

Section: Introductionmentioning

confidence: 99%

Solid organ donation from the emergency department – A systematic review

McCallum

Ellis

Dhanani

et al. 2019

CJEM

View full text Add to dashboard Cite

ObjectivesA significant gap exists between people awaiting an organ transplant and organ donors. The purpose of this study was to determine what percent of successful donors come from the emergency department (ED), whether there are any missed donors, and to identify factors associated with successful and missed donation.MethodsThis systematic review used electronic searches of EMBASE, MEDLINE, and CINAHL according to PRISMA guidelines on July 7, 2017. We included primary literature in adults describing successful and missed organ donation. Two authors independently screened articles, and discrepancies were resolved through consensus. Quality was assessed using the STROBE checklist.ResultsThis systematic review identified 1,058 articles, and 25 articles were included. For neurologic determination of death, ED patients comprised 4%–50% of successful donors and 3.6%–8.9% of successful donors for donation after circulatory determination of death. ED death reviews revealed up to 84% of missed neurologic determination of death, and 46.2% of missed circulatory determination of death donors who died in the ED are missed due to a failure to refer for consideration of organ donation. Clinical heterogeneity precluded pooling of the data to conduct a meta-analysis.ConclusionsThe ED is a source of actual and missed donors. Potential donors are often missed due to incorrect assumptions regarding eligibility criteria and failure of the healthcare team to refer for consideration of donation. ED healthcare professionals should be aware of organ donation referral protocols at their institution to ensure that no organ donors are missed.

show abstract

Organ donation in trauma victims: A systematic review and meta-analysis

Abstract: Systematic reviews and meta-analyses level III.

Cited by 9 publications

References 31 publications

Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy

Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy

Lebensrettende Maßnahmen bei Kindern (Paediatric Life Support, PLS)

Solid organ donation from the emergency department – A systematic review

Contact Info

Product

Resources

About