Organ-on-chip systems as a model for nanomedicine

Stavrou, Marios; Phung, Ngan B.; Grimm, Jan; Andreou, Chrysafis

doi:10.1039/d3nr01661g

Cited by 11 publications

(2 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To further deepen our knowledge of nano-bio interactions, efficient experimental and theoretical models to predict nanomaterials’ in vivo behavior would be necessary. Animal-free tissue models, including microfluidic organ-on-chips and organoids, have showed great potential for high-throughput analysis of nano-bio interface in complex tissue microenvironment [ 153 , 154 ]. In current nanomedicine, the application of these models was mainly limited to toxicity assessment, and how to construct animal-free organ models to study different types of nano-bio interactions remained largely unclear.…”

Section: Understanding Nano-bio Interactionsmentioning

confidence: 99%

Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities

Wang,

Zhao,

Nie

2023

Medical Review

View full text Add to dashboard Cite

Intelligent nanomedicine is currently one of the most active frontiers in cancer therapy development. Empowered by the recent progresses of nanobiotechnology, a new generation of multifunctional nanotherapeutics and imaging platforms has remarkably improved our capability to cope with the highly heterogeneous and complicated nature of cancer. With rationally designed multifunctionality and programmable assembly of functional subunits, the in vivo behaviors of intelligent nanosystems have become increasingly tunable, making them more efficient in performing sophisticated actions in physiological and pathological microenvironments. In recent years, intelligent nanomaterial-based theranostic platforms have showed great potential in tumor-targeted delivery, biological barrier circumvention, multi-responsive tumor sensing and drug release, as well as convergence with precise medication approaches such as personalized tumor vaccines. On the other hand, the increasing system complexity of anti-cancer nanomedicines also pose significant challenges in characterization, monitoring and clinical use, requesting a more comprehensive and dynamic understanding of nano-bio interactions. This review aims to briefly summarize the recent progresses achieved by intelligent nanomaterials in tumor-targeted drug delivery, tumor immunotherapy and temporospatially specific tumor imaging, as well as important advances of our knowledge on their interaction with biological systems. In the perspective of clinical translation, we have further discussed the major possibilities provided by disease-oriented development of anti-cancer nanomaterials, highlighting the critical importance clinically-oriented system design.

show abstract

Section: Understanding Nano-bio Interactionsmentioning

confidence: 99%

Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities

Wang,

Zhao,

Nie

2023

Medical Review

View full text Add to dashboard Cite

show abstract

“…PLGA-coated nanoparticles can not only bypass the blood-brain barrier through size-based passive internalization osmosis to target drug delivery to the brain, but also improve drug targeting distribution to enhance efficacy [ 16 , 17 ]. Microfluidic chips can help the high-speed preparation of nanomaterials due to their advantages of miniaturization, intelligence and integration [ 18 ]. In this study, we designed m icrofluidic electroporation chip prepared m esenchymal stem cell-derived neuron-like cell membrane-coated cur cumin PLGA n ano p article s (MM-Cur-NPs) to explore the synergistic efficacy of natural cell membrane-encapsulated drugs for PD.…”

Section: Introductionmentioning

confidence: 99%

Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease

Lei,

Li,

Liu

et al. 2024

J Nanobiotechnol

View full text Add to dashboard Cite

Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural cell membrane drugs are used for homologous targeting to enhance efficacy. In this study, microfluidic electroporation chip prepared mesenchymal stem cell-derived neuron-like cell membrane-coated curcumin PLGA nanoparticles (MM-Cur-NPs) was synthesized and explored therapeutic effect and mechanism in PD. MM-Cur-NPs can protect neuron from damage, restore mitochondrial membrane potential and reduce oxidative stress in vitro. In PD mice, it also can improve movement disorders and restore damaged TH neurons. MM-Cur-NPs was found to be distributed in the brain and metabolized with a delay within 24 h. After 1 h administration, MM-Cur-NPs were distributed in brain with a variety of neurotransmitters were significantly upregulated, such as dopamine. Differentially expressed genes of RNA-seq were enriched in the inflammation regulation, and it was found the up-expression of anti-inflammatory factors and inhibited pro-inflammatory factors in PD. Mechanically, MM-Cur-NPs can not only reduce neuronal apoptosis, inhibit the microglial marker IBA-1 and inflammation, but also upregulate expression of neuronal mitochondrial protein VDAC1 and restore mitochondrial membrane potential. This study proposes a therapeutic strategy provide neuroprotective effects through MM-Cur-NPs therapy for PD.

show abstract

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Wang,

Yung,

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Nanotechnology‐based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ‐on‐a‐chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology‐biology interactions. This review covers first recent advances and applications of MSK OoCs and their ability to mimic the biophysical and biochemical stimuli encountered by MSK tissues. Next, by integrating nanotechnology into MSK OoCs, cellular responses and tissue behaviors may be investigated by precisely controlling and manipulating the nanoscale environment. Analysis of MSK disease mechanisms, particularly bone, joint, and muscle tissue degeneration, and drug screening and development of personalized medicine may be greatly facilitated using MSK OoCs. Finally, we outline future challenges and directions for the field, including advanced sensing technologies, integration of immune‐active components, and enhancement of biomimetic functionality. By highlighting the emerging applications of MSK OoCs, this review aims to advance our understanding of the intricate nanotechnology‐MSK biology interface and its significance in MSK disease management, and the development of innovative and personalized therapeutic and interventional strategies.This article is protected by copyright. All rights reserved

show abstract

Organ-on-chip systems as a model for nanomedicine

Abstract: Nanomedicine is giving rise to increasing numbers of successful drugs, including cancer treatments, molecular imaging agents, and novel vaccine formulations. However, traditionally available model systems offer limited clinical translation and,...

Cited by 11 publications

References 91 publications

Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities

Intelligent nanomaterials for cancer therapy: recent progresses and future possibilities

Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Contact Info

Product

Resources

About