Organ‐PAM: Photoacoustic Microscopy of Whole‐organ Multiset Vessel Systems

Zhang, Junning; Peng, Dinglu; Qin, Wei; Qi, Weizhi; Liu, Xiaoya; Luo, Yucheng; Guo, Qiongyu; Xi, Lei

doi:10.1002/lpor.202201031

Cited by 8 publications

(2 citation statements)

References 49 publications

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“…For more dedicated applications of PAM, Xi et al. 45 – 47 introduced several interesting PAM platforms with versatile applications. The organ-PAM platform enables high-resolution imaging of multiple vessel systems within organs, revealing insights into pathological conditions.…”

Section: Pai Plus Advanced Electrical and Mechanical Hardwarementioning

confidence: 99%

Photoacoustic imaging plus X: a review

Jiang,

Zhu,

Tong

et al. 2023

J. Biomed. Opt.

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. Significance Photoacoustic (PA) imaging (PAI) represents an emerging modality within the realm of biomedical imaging technology. It seamlessly blends the wealth of optical contrast with the remarkable depth of penetration offered by ultrasound. These distinctive features of PAI hold tremendous potential for various applications, including early cancer detection, functional imaging, hybrid imaging, monitoring ablation therapy, and providing guidance during surgical procedures. The synergy between PAI and other cutting-edge technologies not only enhances its capabilities but also propels it toward broader clinical applicability. Aim The integration of PAI with advanced technology for PA signal detection, signal processing, image reconstruction, hybrid imaging, and clinical applications has significantly bolstered the capabilities of PAI. This review endeavor contributes to a deeper comprehension of how the synergy between PAI and other advanced technologies can lead to improved applications. Approach An examination of the evolving research frontiers in PAI, integrated with other advanced technologies, reveals six key categories named “PAI plus X.” These categories encompass a range of topics, including but not limited to PAI plus treatment, PAI plus circuits design, PAI plus accurate positioning system, PAI plus fast scanning systems, PAI plus ultrasound sensors, PAI plus advanced laser sources, PAI plus deep learning, and PAI plus other imaging modalities. Results After conducting a comprehensive review of the existing literature and research on PAI integrated with other technologies, various proposals have emerged to advance the development of PAI plus X. These proposals aim to enhance system hardware, improve imaging quality, and address clinical challenges effectively. Conclusions The progression of innovative and sophisticated approaches within each category of PAI plus X is positioned to drive significant advancements in both the development of PAI technology and its clinical applications. Furthermore, PAI not only has the potential to integrate with the above-mentioned technologies but also to broaden its applications even further.

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Section: Pai Plus Advanced Electrical and Mechanical Hardwarementioning

confidence: 99%

Photoacoustic imaging plus X: a review

Jiang,

Zhu,

Tong

et al. 2023

J. Biomed. Opt.

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“…Optical-resolution photoacoustic microscopy (OR-PAM), characterized by subcellular resolution, rich optical contrasts, and label-free imaging capability, has shown inspiring prospects in anatomical, functional, and histological studies [1] , [2] , [3] , [4] , [5] , [6] , [7] . A fast scanning speed plays a crucial role in enhancing throughput and enabling the study of dynamic physiological or pathological processes in vivo [8] , [9] .…”

Section: Introductionmentioning

confidence: 99%

Unsupervised deep learning enables real-time image registration of fast-scanning optical-resolution photoacoustic microscopy

Hong,

Tang,

Wang

et al. 2024

Photoacoustics

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Wavelength‐switchable synchronously pumped Raman fiber laser near 1.7 µm for multispectral photoacoustic microscopy

Park,

Bak,

Kim

et al. 2024

Laser & Photonics Reviews

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We present a wavelength‐switchable, synchronously pumped Raman fiber laser based on a dual‐cavity design operating in the 1.7 µm region, specifically developed for multispectral photoacoustic microscopy (PAM). By precisely engineering the lengths of the pump laser cavity and the Raman laser cavity and meticulously controlling the modulation frequency, we achieved synchronous pumping by synchronizing the Stokes light within the Raman laser cavity to have the identical round‐trip time as the pump light. Adjusting the electrical modulation frequency of the pump laser to 126.398 kHz, 128.136 kHz, and 130.808 kHz enabled rapid switching of the Raman laser output to final wavelengths of 1700.2 nm, 1710.4 nm, and 1720.3 nm, respectively, with a pulse duration of 4 ns and a pulse energy exceeding 500 nJ. Integrating this advanced laser into a near‐infrared PAM system facilitated the acquisition of spectroscopic photoacoustic signals and images from polymer films with distinct C─H compositions: polyethylene, polypropylene, and polyimide. Our results demonstrate the efficacy of the proposed laser for wavelength switching in the 1700 nm region and its significant potential for differentiating molecules with various C─H groups in PAM applications.

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Organ‐PAM: Photoacoustic Microscopy of Whole‐organ Multiset Vessel Systems

Cited by 8 publications

References 49 publications

Photoacoustic imaging plus X: a review

Photoacoustic imaging plus X: a review

Unsupervised deep learning enables real-time image registration of fast-scanning optical-resolution photoacoustic microscopy

Wavelength‐switchable synchronously pumped Raman fiber laser near 1.7 µm for multispectral photoacoustic microscopy

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