Organ perfusion during partial REBOA in haemorrhagic shock: dynamic 4D-CT analyses in swine

Abstract

Resuscitative endovascular balloon occlusion of the aorta (REBOA) increases proximal blood pressure while inducing distal ischemia of visceral organs. The evaluation of distal ischemia severity during REBOA is a prerequisite for safe resuscitation of haemorrhagic shock patients with REBOA. We evaluated changes in blood flow and organ perfusion due to the degree of occlusion using dynamic 4D-computed tomography (CT). We compared the results with those of a previous study on euvolemic status. Delayed enhancement of the inferior vena cava (IVC) without retrograde flow was observed in the 4D-volume rendering images in the high-degree occlusion. The time-density curve (TDC) of the liver parenchyma (liver perfusion) and superior mesenteric vein (SMV) demonstrated a decreased peak density and a delayed peak in high-degree occlusion. The change rate of the area under the TDC of the liver and SMV decreased linearly as the degree of occlusion increased (PV, Y = −1.071*X + 106.8, r2 = 0.972, P = 0.0003; liver, Y = −1.050*X + 101.8, r2 = 0.933, P = 0.0017; SMV, Y = −0.985*X + 100.3, r2 = 0.952, P = 0.0009). Dynamic 4D-CT revealed less severe IVC congestion during P-REBOA in haemorrhagic shock than in euvolemia. Analyses of TDC of the liver and SMV revealed a linear change in organ perfusion, regardless of intravascular volume.

Continuous renal replacement therapy with cytokine-adsorbing hemofilter to control resuscitative endovascular balloon occlusion of the aorta-related ischemia-reperfusion injury in a swine hemorrhagic shock model

“…Partial REBOA minimizes distal organ ischemia by regulating the aortic ow via partial balloon in ation. Changes in distal organ blood ow following changes in balloon volume during partial REBOA have been previously reported [17,25]. Partial REBOA has been applied clinically and is expected to improve mortality; however, its effectiveness has not been demonstrated in a recent clinical research [26].…”