Organ preservation in advanced head and neck cancer

Dibb, Charles R.; Urba, Susan G.; Wolf, Gregory T.

doi:10.1007/978-1-4615-2023-8_11

Cited by 2 publications

(10 citation statements)

References 60 publications

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“…Three analyses were conducted within Dibb’s work of an adult model: a simplified condition, relative to the present study, of the NBDL15 ( Figure 2G ) trial, pure tension experiment, and flexion and extension testing via pendulum. Results of the NBDL15 trial between the present work and that of Dibb et al show that the current study exhibits increased head displacement and acceleration [consistent with their findings ( Dibb, 2011 , pg. 127)], marginally reduced neck rotation (roughly 1.5 degrees less, due to the contact of the head to the chest in the present study), increased forces, and decreased moments.…”

Section: Discussionsupporting

confidence: 92%

“…Muscle activation was not involved in either model for any of the presented simulations to remove a potentially confounding factor. Noted in previous work for the case of frontal impact, the kinematic response (peaks of: head and neck rotation, head lag time, as well as head CG displacement, x and z linear acceleration, and y-rotational acceleration) of the modeled head-neck complex was most sensitive to extensor muscle level activation ( Dibb, 2011 , pg. 127).…”

Section: Methodsmentioning

confidence: 90%

“…In these aforementioned cases, the head of the M50-OS does not continue further into the +Z direction in the same way that the M50-O does. Dibb et al, whose research provided the foundational work related to the design of the M50-OS neck architecture, noted that secant bending stiffness of the simplified neck is only sensitive to parameters of the simplified muscle elements ( Dibb, 2011 , pg. 130).…”

Section: Discussionmentioning

confidence: 99%

“…In the case of NBDL15, Dibb et al noted several influential parameters affecting model response, in which response is taken to be OC2 peak tension force, OC2 peak extension moment, OC2 Nij, and neck bending stiffness. Aside from initial acceleration within the boundary condition, the most significant parameters studied were extensor activation level and reflex time, muscle attachment location, PCSA, max isometric stress, as well as flexion and extension stiffness parameters of the osteoligamentous joint space ( Dibb, 2011 , pg. 132).…”

Section: Discussionmentioning

confidence: 99%

“…The simplified model neck bony geometry is identical to that of the detailed model but additional anatomy was modeled based on previously established methodology ( Dibb, 2011 , pg. 36–53).…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Neck Injury Criteria Values Across Human Body Models of Varying Complexity

Johnson

Koya

Gayzik

2020

Front. Bioeng. Biotechnol.

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Due to the severity and frequency of cervical spine injuries, the neck injury criterion (Nij) was developed to provide a quantitative relationship between forces and moments of the upper neck with accompanied injury risk. The present study was undertaken to evaluate differences in calculated Nij for the Global Human Body Model Consortium's detailed and simplified average 50th percentile male models. The simplified model is a computationally light version of the more detailed model and therefore it is of interest to achieve similar Nij values between the two models. These models were compared in 15 match paired conditions of rigid head impact and a mixture of seven full body rigid hub and sled pulses, for 44 total simulations. Collectively, Nij values of the simplified model were found to exhibit a second-degree polynomial fit, allowing for a conversion to the prediction of the detailed model. Correlates were also derived for impact and inertial loading cases individually, for which the latter may be the subject of future work. The differences in Nij may be attributed to a variety of modeling approach differences related to neck muscles (attachment location and morphometric implementation), localization of head mass within the M50-OS, head geometry, and intervertebral joint space properties. With a primary focus on configurations in the anterior-posterior direction, there is a potential limitation in extensibility to lateral loading cases. In response to the relatively low Nij values exhibited, future work should evaluate the appropriateness of the established critical intercepts of Nij for computational human body models.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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