Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes

Xu, Siyuan; Huang, Ying; Huang, Hui; Qian, Ji; Wang, Kai; Wu, Yuehuang; Wang, Xiaolei; Xu, Zhengang; Liu, Shaoyan; Liu, Jie

doi:10.1007/s00405-021-07182-w

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…However, the overall rate of laryngeal function preservation was 90.9% (20/22). In the past, patients with hypopharyngeal carcinomas at T3 and above accompanied by unilateral vocal cord fixation were usually treated with total laryngectomy ( 21 ). Of the 9 patients with postcricoid region involvement accompanied by unilateral vocal cord fixation in this study, only 2 underwent total laryngectomy, while the others were treated with partial laryngectomies and hypopharyngeal resections to achieve radical resection with R0.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas

Wang,

Gui,

et al. 2023

Front. Immunol.

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BackgroundThis study aimed to explore the efficacy and safety of pembrolizumab combined with chemotherapy as neoadjuvant therapy in patients with resectable locally advanced head and neck squamous cell carcinomas (LA-HNSCCs).MethodsIn this prospective, single-arm, single-centre clinical trial, patients meeting the inclusion criteria were treated with preoperative neoadjuvant therapy with 200 mg pembrolizumab combined with 75 mg/m2 cisplatin and 175 mg/m2 paclitaxel. This was followed by surgery and postoperative adjuvant therapy. The primary endpoint was the postoperative pathological complete response (pCR) rate. All statistical analyses were performed using SPSS 26.ResultsA total of 22 patients were enrolled. The location of primary lesion showed: hypopharynx were 15 (68.2%), oropharynx were 6 (27.3%) and oral cavity was 1 (4.5%). The postoperative pCR rate, was 36.4% (8/22), and there was no delay to surgery due to adverse drug reactions. The rate of laryngeal function preservation was 90.9% (20/22). Delayed wound healing was the main surgical complication, with an incidence of 22.7% (5/22). The median follow-up time was 9.5 months, and only 1 patient (4.55%) suffered a regional recurrence.ConclusionPreoperative treatment with pembrolizumab and chemotherapy in resectable LA-HNSCC has a high pCR rate with no significant impact on surgical safety. This treatment was found to increase the rate of laryngeal function preservation. However, the effects of neoadjuvant immunotherapy on long-term prognosis in LA-HNSCCs require further study.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas

Wang,

Gui,

et al. 2023

Front. Immunol.

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Application of pedicled supraclavicular flaps in hypopharyngectomy with preservation of laryngeal function

Zhou,

Li,

Feng

et al. 2024

BMC Surg

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Current Therapeutic Strategies for Patients with Hypopharyngeal Carcinoma: Oncologic and Functional Outcomes

Bozec

Poissonnet

Dassonville

et al. 2023

JCM

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Hypopharyngeal cancer is usually diagnosed at an advanced stage and is associated with a high risk of recurrence and poor survival rates. Although they differ greatly in terms of prognosis, hypopharyngeal cancers are usually treated together with laryngeal cancers in clinical trials. Therefore, there are very few studies that focus specifically on patients with hypopharyngeal carcinoma. As a result, the therapeutic management of these patients is highly debated, and their clinical outcomes are poorly reported. The aim of this review is therefore to discuss the current therapeutic options in patients with hypopharyngeal carcinoma and their oncologic and functional outcomes. Patients with early-stage tumors can be treated either by conservative surgery (including transoral robot-assisted surgery) or by RT alone. However, most patients are diagnosed with locally advanced tumors that cannot be treated surgically without total laryngectomy. In this situation, the critical issue is to select the patients eligible for a larynx preservation therapeutic program. However, radical surgery with total laryngectomy still plays an important role in the management of patients with hypopharyngeal carcinoma, either as the primary treatment modality (T4 resectable primary tumor, contraindication to larynx preservation therapies) or, more commonly, as salvage treatment.

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Organ preservation surgery for pyriform sinus carcinoma with vocal cord fixation: functional and oncological outcomes

Cited by 3 publications

References 11 publications

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas

Application of pedicled supraclavicular flaps in hypopharyngectomy with preservation of laryngeal function

Current Therapeutic Strategies for Patients with Hypopharyngeal Carcinoma: Oncologic and Functional Outcomes

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