Organ specific Gst‐pi expression of the metastatic androgen independent prostate cancer cells in nude mice

Abstract

Gst-pi expression of the prostate cancers are dependent on metastatic site, and that Gst-pi has an important role in adapting prostate cancer for growth and metastasis involving an alteration of ROS signals.

Filamin A interacting protein 1‐like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis

“…However, experimental lung metastasis, which does not need initial invasion and intravasation, was detected by 28 days (1 × 10 6 cells per mouse were injected). A similar phenomenon was reported using prostate cancer cells, PCai1 . We speculate that the ovarian microenvironment may facilitate lung metastasis for cell lines such as ES2 by promoting tumor growth or secreting hormones.…”

Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism

“…Similarly, PRE-HIF down-regulated AR expression in the rat CRPC cell line, PCai1. Although PCai1 cell growth was androgen-independent, increased AR expression was clearly observed compared to human prostate cancer cell lines [18]. In addition, AR amplification is associated with resistance to ADT and promotes CRPC progression [32].…”

“…In addition to an androgen-sensitive phase, we evaluated the effect of PRE-HIF on androgen-insensitive prostate cancer using PCai1 cells. A novel rat CRPC cell line, PCai1, was previously established from an androgen-nonresponsive tumor [18]. This, therefore, suggests that PCai1 cells may be a good model that illustrates human CRPC [19].…”

Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats

“…Therefore it is necessary to establish various kinds of experimental systems. We have focused on a series of animal models for various prostate cancer phenotypes: noninvasive and castration-sensitive cancer 19 , 20 , 21 , invasive and castration-sensitive cancer 22 , invasive and castration-resistant cancer 4 and metastatic and castration-resistant cancer 23 models. In the present study, we developed a syngeneic orthotopic implantation model with metastases in a short period using a prostate cancer cell line, PLS10, in immunocompetent rats.…”