Organ-specific lymphatic vasculature: From development to pathophysiology

Petrova, Tatiana V.; Koh, Gou Young

doi:10.1084/jem.20171868

Cited by 253 publications

(257 citation statements)

References 117 publications

(172 reference statements)

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“…It remains to be investigated whether the polarized LV–HF association is dependent on the existence of differentially expressed molecules at the anterior/posterior sides of the HF, thereby creating a distinct connection similar to the one documented between HF and the apm (Fujiwara et al , ). The nature of the lymphatic endothelial cells associated with HF is also intriguing, since they are plastic and heterogeneous among organs (Jang et al , ; Martinez‐Corral et al , ; Petrova & Koh, ). Thus, a defined population may exert specific functions at HF, compared to lymphatic endothelial cells distributing at other anatomical locations within the skin.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

et al. 2019

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Lymphatic vessels are essential for skin fluid homeostasis and immune cell trafficking. Whether the lymphatic vasculature is associated with hair follicle regeneration is, however, unknown. Here, using steady and live imaging approaches in mouse skin, we show that lymphatic vessels distribute to the anterior permanent region of individual hair follicles, starting from development through all cycle stages and interconnecting neighboring follicles at the bulge level, in a stem cell‐dependent manner. Lymphatic vessels further connect hair follicles in triads and dynamically flow across the skin. At the onset of the physiological stem cell activation, or upon pharmacological or genetic induction of hair follicle growth, lymphatic vessels transiently expand their caliber suggesting an increased tissue drainage capacity. Interestingly, the physiological caliber increase is associated with a distinct gene expression correlated with lymphatic vessel reorganization. Using mouse genetics, we show that lymphatic vessel depletion blocks hair follicle growth. Our findings point toward the lymphatic vasculature being important for hair follicle development, cycling, and organization, and define lymphatic vessels as stem cell niche components, coordinating connections at tissue‐level, thus provide insight into their functional contribution to skin regeneration.

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Section: Discussionmentioning

confidence: 99%

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

et al. 2019

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“…Then malfunction of these meningeal lymphatic vessels could be a cause of different pathological brain conditions in which altered immunity plays a key role, such as multiple sclerosis, Alzheimer's disease (AD), and possibly other aging‐related disorders. A significant decline in CSF outflow via meningeal lymphatics was observed in aged mice, implying that meningeal lymphatic network could be targeted for age‐associated neurological conditions …”

Section: Senescence In the Brain And Its Physiological Rolementioning

confidence: 99%

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain

Spinelli

Martucciello

Nori

et al. 2018

Journal of Leukocyte Biology

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Ongoing studies evidence cellular senescence in undifferentiated and specialized cells from tissues of all ages. Although it is believed that senescence plays a wider role in several stress responses in the mature age, its participation in certain physiological and pathological processes throughout life is coming to light. The "senescence machinery" has been observed in all brain cell populations, including components of innate immunity (e.g., microglia and astrocytes). As the beneficial versus detrimental implications of senescence is an open question, we aimed to analyze the contribution of immune responses in regulatory mechanisms governing its distinct functions in healthy (development, organogenesis, danger patrolling events) and diseased brain (glioma, neuroinflammation, neurodeneration), and the putative connection between cellular and molecular events governing the 2 states. Particularly this review offers new insights into the complex roles of senescence both as a chronological event as age advances, and as a molecular mechanism of brain homeostasis through the important contribution of innate immune responses and their crosstalk with neighboring cells in brain parenchyma. We also highlight the impact of the recently described glymphatic system and brain lymphatic vasculature in the interplay between peripheral and central immune surveillance and its potential implication during aging. This will open new ways to understand brain development, its deterioration during aging, and the occurrence of several oncological and neurodegenerative diseases.

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“…The lymphatic vasculature facilitates the drainage of interstitial fluids to maintain fluid homeostasis and acts as a passage way for certain immune cell populations, though the lymphatic vasculature has other important organ and tissue specific functions (reviewed in (Petrova & Koh, 2018). Lymphatic vessels are made up of lymphatic endothelial cells (LECs) and differ greatly from the blood vasculature, lacking perivascular cells like pericytes or vascular smooth muscle cells (vSMCs), are surrounded by an intermittent basement membrane and have specialized, discontinuous cell junctions that allow fluid and immune cells to enter the vessel lumen.…”

Section: Retinoic Acid In Development Of the Embryonic Lymphatic Vascmentioning

confidence: 99%

Retinoic acid signaling in vascular development

Pawlikowski

Wragge

Siegenthaler

2019

Genesis

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Formation of the vasculature is an essential developmental process, delivering oxygen and nutrients to support cellular processes needed for tissue growth and maturation. Retinoic acid (RA) and its downstream signaling pathway is vital for normal pre- and post-natal development, playing key roles in the specification and formation of many organs and tissues. Here we review the role of RA in blood and lymph vascular development, beginning with embryonic yolk sac vasculogenesis and remodeling and discussing RA’s organ-specific roles in angiogenesis and vessel maturation. In particular, we highlight the multi-faceted role of RA signaling in CNS vascular development and acquisition of blood-brain barrier properties.

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Organ-specific lymphatic vasculature: From development to pathophysiology

Cited by 253 publications

References 117 publications

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

Innate immunity and cellular senescence: The good and the bad in the developmental and aged brain

Retinoic acid signaling in vascular development

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