1978
DOI: 10.1111/j.1365-2141.1978.tb03661.x
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Organelle Pathology in Primary and Secondary Haemochromatosis with Special Reference to Lysosomal Changes

Abstract: The organelle pathology of liver biopsy specimens from patients with either primary or secondary haemochromatosis was investigated by analytical subcellular fractionation in combination with enzymic microanalysis. The most striking changes were found in the lysosomes. Increased total activities but decreased latent activities of enzymes selectively localized to the high density population of lysosomes was demonstrated in the iron overloaded biopsies. Depletion of the iron, where possible, by venesection was ac… Show more

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Cited by 103 publications
(41 citation statements)
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“…Furthermore, the mechanism by which the excess iron initiates tissue damage is unknown but may involve iron-induced lipid peroxidation and other free-radical-mediated toxic effects, lysosomal disruption (Seymour and Peters, 1977;Seldon et al, 1980) and mitochondria1 and microsomal malfunction (Bacon et al, 1983).…”
mentioning
confidence: 99%
“…Furthermore, the mechanism by which the excess iron initiates tissue damage is unknown but may involve iron-induced lipid peroxidation and other free-radical-mediated toxic effects, lysosomal disruption (Seymour and Peters, 1977;Seldon et al, 1980) and mitochondria1 and microsomal malfunction (Bacon et al, 1983).…”
mentioning
confidence: 99%
“…On the other hand, hepcidin knockout mice fed iron-rich diet showed only minor changes in mitochondrial and cytoplasmatic iron content and similarly, mitochondrial iron accumulation is uncommon in HH [95] as well as in animals fed with ferrocene or ironcarbonyl containing diet [159,162]. These findings are not surprising since mitochondrial iron trafficking seems to be controlled independently on systemic iron levels and mitochondrial iron overload develops primarily due to defect in genes responsible for heme biosynthesis, iron-sulfur clusters biogenesis or mitochondrial iron transport [2,166,167].…”
Section: Discussionmentioning
confidence: 99%
“…In situation of iron overload, lysosomal iron is also stored in the form of hemosiderin [93,94,95,96]. Such an lysosomal iron accumulation is found in hemochromatosis patients [97] and these lysosomes are proins to generation of free iron which leads to oxidative stress and may result in apoptosis [96,98].…”
Section: Iron Toxicity Via Reactive Oxygen Species (Ros) Mechanism Omentioning
confidence: 99%
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“…Increased lability of iron-loaded lysosomes leads to increased autophagy of hepatocytes accounting for the characteristic changes in liver biopsy specimens from haemochromatotic patients [94]. In mitochondria iron-induced lipid peroxidation impairs among other enzymes the activity of cytochrome oxidase, the terminal enzyme of the mitochondria1 electron transport chain [56].…”
Section: Mechanism Of Iron Induced Cellular Toxicitymentioning
confidence: 99%