Organic Acids in Urine from Preterm Infants

C, Conde González; Mazza, M; Almar, Jordi; Seijo, Guillermo; Ballabriga, A

doi:10.1159/000241205

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…To investigate this hypothesis in hypoglycemic infants, we measured the urinary excretion of dicarboxylic acids in hypoglycemic and normoglycemic infants of group II. The val ues detected in the present study are slightly lower than those previously reported in neo nates [18,19]; the differences may be ex plained by the early timing in the present study and by the influence of feeding in the other reports. In the hypoglycemic infants, we did not observe an elevated urinary ex cretion of dicarboxylic acids in comparison to the normoglycemic infants.…”

Section: Discussioncontrasting

confidence: 91%

Ketogenesis in Hypoglycemic Neonates

Sann

Divry²,

B³

et al. 1987

Neonatology

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Since hypoglycemic neonates do not exhibit compensative ketosis, we investigated the possible involvement of carnitine deficiency or Ω-oxidation in neonatal hypoglycemia. In a first group of 49 neonates, serum free fatty acid, acetoacetate and β-hydroxybutyrate concentrations were similar in hypoglycemic and normoglycemic neonates. Serum free carnitine concentrations did not show any difference in the hypoglycemic small-for-date infants (median 40 μmol/l, range 16–92 μmol/l) compared to the normoglycemic small-for-date infants (median 30 μmol/l, range 8–64 μmol/l). In a second group of 45 neonates, urinary excretion of dicarboxylic acids (adipic, suberic, sebaric and succinic acids) was similar in hypoglycemic infants compared to normoglycemic neonates. Despite the limitations of interpretaion of free carnitine determination, these data do not suggest an impaired β-oxidation by carnitine depletion or an enzymatic defect in hypoglycemic neonates.

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Section: Discussioncontrasting

confidence: 91%

Ketogenesis in Hypoglycemic Neonates

Sann

Divry²,

B³

et al. 1987

Neonatology

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Urinary organic acid excretion by babies born before 33 weeks of gestation.

Walker

Mills

1989

Clinical Chemistry

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Using analytical procedures that are widely used by laboratories investigating metabolic disorders, we investigated urinary organic acid excretion by premature neonates who were receiving the usual clinical care. Our purpose was to provide a basis for the diagnosis of inherited organic acid defects. We analyzed 127 random (untimed) urine samples collected weekly from 22 infants of 25-32 weeks of gestation (median, 28 weeks). A wide variety of organic acids was excreted. After oximation, they were extracted with ethyl acetate and diethyl ether, derivatized to trimethylsilyl forms, and analyzed by gas-liquid chromatography on a nonpolar fused silica capillary column, with mass spectrometry for identification. Profiles for individual babies varied markedly on different occasions, reflecting their metabolic status and bacterial activity in the gut. There was no significant ketonuria. Three metabolites identified for the first time in urine from normal neonates were 2,3-butanediol, 3-hydroxy-2-butanone (acetoin), and 4-hydroxy-3-methoxyphenyllactic acid. Significantly increased excretion of 4-hydroxyphenyllactic acid and other phenolic acids occurred during parenteral feeding.

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Organic Acids in Urine from Preterm Infants

Cited by 2 publications

References 6 publications

Ketogenesis in Hypoglycemic Neonates

Ketogenesis in Hypoglycemic Neonates

Urinary organic acid excretion by babies born before 33 weeks of gestation.

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