Organic analysis with a combined capillary gas chromatograph mass spectrometer Fourier transform infrared spectrometer

Crawford, R.W.; Hirschfeld, Tomas; Sanborn, Russell H.; Wong, Carla M.

doi:10.1021/ac00241a051

Cited by 58 publications

(17 citation statements)

References 20 publications

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“…In early papers describing the operation of GC-FTIR-MS systems, the utility of the complementary information thus available was demonstrated by using simple test mixtures, first with packed GC columns and a high-resolution double-focusing mass spectrometer (4) and later with a support-coated open tubular (SCOT) GC column and a low-resolution quadrupole mass spectrometer (26). Test mixtures difficult to analyze by either FTIR or MS alone were chosen to demonstrate the potential power of the combined approach for compound identification.…”

Section: Direct-linked Gc-ftir-msmentioning

confidence: 99%

“…By following precisely the same manual cross-correlation procedure, using the same two data bases, a similar sixcomponent test-mixture, containing the xylene isomers as well as other compounds, was analyzed by other workers (26). In that study, in which a SCOT column was used for the separation, two of the xylenes were incompletely separated.…”

Section: Direct-linked Gc-ftir-msmentioning

confidence: 99%

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Hyphenated Techniques for Analysis of Complex Organic Mixtures

Wilkins

1983

Science

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Advances in computer technology as well as analytical instrumentation have made practical analytical systems combining various separation methods and multiple spectrometric detectors. Systems consisting of a separation device and a detector, such as gas chromatography-mass spectrometry (GC-MS), are already widely used. Newer methods employing two or more detectors in addition to a separation device are exemplified by gas chromatography-Fourier transform infrared spectroscopy-mass spectrometry (GC-FTIR-MS). A GC-FTIR-MS system has been used in different configurations for the analysis of two relatively complex mixtures of about 30 compounds. Complementary information obtained with such a multi-instrument system shows that it is a potentially powerful tool for complex mixture analysis.

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Section: Direct-linked Gc-ftir-msmentioning

confidence: 99%

Section: Direct-linked Gc-ftir-msmentioning

confidence: 99%

Hyphenated Techniques for Analysis of Complex Organic Mixtures

Wilkins

1983

Science

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“…Gas chromatography with Fourier transform infrared detection (GC-FT-IR) was first introduced in the late 1960s to help identify non-enantiomeric compounds that yield ambiguous results using GC-MS. 1,2 However, use of GC-FT-IR in lieu of GC-MS often requires a significant sacrifice in sensitivity, which is why a fully integrated GC-FT-IR-MS is attractive for examining a wider range of analytes and concentrations compared to what can be achieved using GC-MS or GC-FT-IR independently. [3][4][5][6] Recently, Lanzarotta et al employed a fully integrated GC-FT-IR-MS to identify and confirm the presence of sibutramine and AB-FUBINACA. 7 Sibutramine, a DEA schedule IV oral anorexiant, yields a non-specific fragmentation pattern.…”

Section: Introductionmentioning

confidence: 99%

Forensic Drug Identification, Confirmation, and Quantification Using Fully Integrated Gas Chromatography with Fourier Transform Infrared and Mass Spectrometric Detection (GC-FT-IR-MS)

et al. 2018

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This manuscript is a continuation of a recent study that described the use of fully integrated gas chromatography with direct deposition Fourier transform infrared detection and mass spectrometric detection (GC-FT-IR-MS) to identify and confirm the presence of sibutramine and AB-FUBINACA. The purpose of the current study was to employ the GC-FT-IR portion of the same instrument to quantify these compounds, thereby demonstrating the ability to identify, confirm, and quantify drug substances using a single GC-FT-IR-MS unit. The performance of the instrument was evaluated by comparing quantitative analytical figures of merit to those measured using an established, widely employed method for quantifying drug substances, high performance liquid chromatography with ultraviolet detection (HPLC-UV). The results demonstrated that GC-FT-IR was outperformed by HPLC-UV with regard to sensitivity, precision, and linear dynamic range (LDR). However, sibutramine and AB-FUBINACA concentrations measured using GC-FT-IR were not significantly different at the 95% confidence interval compared to those measured using HPLC-UV, which demonstrates promise for using GC-FT-IR as a semi-quantitative tool at the very least. The most significant advantage of GC-FT-IR compared to HPLC-UV is selectivity; a higher level of confidence regarding the identity of the analyte being quantified is achieved using GC-FT-IR. Additional advantages of using a single GC-FT-IR-MS instrument for identification, confirmation, and quantification are efficiency, increased sample throughput, decreased consumption of laboratory resources (solvents, chemicals, consumables, etc.), and thus cost.

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“…Several groups in the 1980s demonstrated that when both the IR and mass spectra of components of mixtures that had been separated by GC were available, the probability of correctly identifying each peak in the chromatogram was greatly increased. [2][3][4] However, until recently, the detection limits (or, more accurately, the limits for identification) of most GC/IR interfaces have been two or three orders of magnitude higher than those of GC/ MS instruments, severely restricting the acceptance of GC/IR by the analytical community. If a GC/IR interface were to have the same sensitivity and ease of use as most GC/ MS systems, a strong case could be made that compounds eluting from gas chromatographs should be identified by a combination of mass and infrared spectroscopy.…”

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confidence: 99%