Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial

Oliveira, Amanda Cristine de; Gomes, Anna Paula Oliveira; Rodrigues, Lorena Charife; Cunha, Raisa da Silva; Serra, Thaís Martins; Schincaglia, Raquel Machado; Silva, Marina Alves Coelho; Horst, Maria Aderuza; Rostagno, Maurı́cio A.; Magalhães, Kelly Grace; Cunha, Luíz Carlos da; Botelho, Patrícia Borges

doi:10.3390/app12041973

Cited by 2 publications

(1 citation statement)

References 50 publications

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“…Previous studies have investigated the effect of food derived-by products from grapes [ 37 , 44 ], beetroot [ 43 ], apricot [ 41 , 42 ], jaboticaba [ 15 , 23 ], onion [ 25 ], cranberry [ 24 ], pear [ 16 ], olive [ 26 ], peach [ 17 ], blueberry [ 31 ], and bacuri [ 33 ] on serum lipids. Araújo et al [ 23 ] investigated the effect of jaboticaba peel flour supplementation in rats fed with a hyperlipidemic diet for 4 weeks.…”

Section: Hypolipidemic Activitymentioning

confidence: 99%

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

et al. 2022

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Polyphenols-rich food has been utilized to induce a positive effect on human health. Considering that fruit and vegetable by-products (seeds, pomace, and peels) are sources of polyphenols, previous studies have investigated the effect of dietary supplementation with food by-products on cardiometabolic disorders, such as high fasting blood glucose, dyslipidemia, and obesity. Endothelial dysfunction has also been considered a cardiometabolic parameter, given that it precedes cardiovascular disease. However, there is a scarcity of narrative reviews reporting the effect of food by-product supplementation on cardiometabolic disorders in animal and human clinical trials. In this sense, the present narrative review aims to investigate the impact of fruit and vegetable by-product supplementation on cardiometabolic disorders in humans and animals, exploring the possible mechanisms whenever possible. Research articles were retrieved based on a search of the following databases: PubMed, ScienceDirect, and Google Scholar using the following keywords and synonyms combined: (“fruit by-products” or “food waste” or “pomace” or “bagasse” or “seeds” or “waste products”) AND (“heart disease risk factors” or “endothelial dysfunction” or “atherosclerosis”). It was shown that fruit and vegetable by-products could efficiently improve cardiometabolic disorders in patients with chronic diseases, including hypertension, type II diabetes mellitus, and dyslipidemia. Such effects can be induced by the polyphenols present in food by-products. In conclusion, food by-product supplementation has a positive effect on cardiometabolic disorders. However, further studies investigating the effect of food by-products on cardiometabolic disorders in humans are still necessary so that solid conclusions can be drawn.

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Section: Hypolipidemic Activitymentioning

confidence: 99%

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

et al. 2022

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The effects of organic food on human health: a systematic review and meta-analysis of population-based studies

Jiang,

Pang,

et al. 2023

Nutrition Reviews

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Context Although the nutritional composition of organic food has been thoroughly researched, there is a dearth of published data relating to its impact on human health. Objective This systematic review aimed to examine the association between organic food intake and health effects, including changes in in vivo biomarkers, disease prevalence, and functional changes. Data Sources PubMed, EMBASE, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched from inception through Nov 13, 2022. Data Extraction Both observational and interventional studies conducted in human populations were included, and association between level of organic food intake and each outcome was quantified as “no association,” “inconsistent,” “beneficial correlation/harmful correlation,” or “insufficient”. For outcomes with sufficient data reported by at least 3 studies, meta-analyses were conducted, using random-effects models to calculate standardized mean differences. Data Analysis Based on the included 23 observational and 27 interventional studies, the association between levels of organic food intake and (i) pesticide exposure biomarker was assessed as “beneficial correlation,” (ii) toxic metals and carotenoids in the plasma was assessed as “no association,” (iii) fatty acids in human milk was assessed as “insufficient,” (iv) phenolics was assessed as “beneficial”, and serum parameters and antioxidant status was assessed as “inconsistent”. For diseases and functional changes, there was an overall “beneficial” association with organic food intake, and there were similar findings for obesity and body mass index. However, evidence for association of organic food intake with other single diseases was assessed as “insufficient” due to the limited number and extent of studies. Conclusion Organic food intake was found to have a beneficial impact in terms of reducing pesticide exposure, and the general effect on disease and functional changes (body mass index, male sperm quality) was appreciable. More long-term studies are required, especially for single diseases. Systematic Review Registration PROSPERO registration no. CRD42022350175.

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Organic Beet Leaves and Stalk Juice Attenuates the Glutathione Peroxidase Increase Induced by High-Fat Meal in Dyslipidemic Patients: A Pilot Double-Blind, Randomized, Controlled Trial

Cited by 2 publications

References 50 publications

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

The Role of By-Products of Fruit and Vegetable Processing for the Dietary Treatment of Cardiovascular Risk Factors: A Narrative Review

The effects of organic food on human health: a systematic review and meta-analysis of population-based studies

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