2020
DOI: 10.1021/acscentsci.0c01138
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Organic Chemistry: A Retrosynthetic Approach to a Diverse Field

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Cited by 21 publications
(36 citation statements)
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“…Importantly, the same spectral feature is not observed in the absence of protein (Supplemental Figure 11), suggesting further that binding to the protein active site is required for CT complex formation. 10,22 As no reaction is observed with a brominated analog of 1a, we hypothesize that the CT complex forms between flavin and the σ* C-I orbital rather than the π* of the α,unsaturated ester. Mechanistically, excitation of this complex facilitates electron transfer from flavin to substrate, which results in loss of iodide and the formation of an unstabilized alkyl radical, which then cyclizes to form a resonance stabilized α-acyl radical.…”
Section: Graphical Abstractmentioning
confidence: 91%
“…Importantly, the same spectral feature is not observed in the absence of protein (Supplemental Figure 11), suggesting further that binding to the protein active site is required for CT complex formation. 10,22 As no reaction is observed with a brominated analog of 1a, we hypothesize that the CT complex forms between flavin and the σ* C-I orbital rather than the π* of the α,unsaturated ester. Mechanistically, excitation of this complex facilitates electron transfer from flavin to substrate, which results in loss of iodide and the formation of an unstabilized alkyl radical, which then cyclizes to form a resonance stabilized α-acyl radical.…”
Section: Graphical Abstractmentioning
confidence: 91%
“…Under no circumstance are the criticisms raised by this communication intended to suggest that the affirmative action “Where are they?” finalized just the opposite. In an extremely difficult time, such as that experienced during the current COVID-19 pandemic, 1 3 there is a need for a growing engagement of the academic chemistry community in Brazil. 5 , 8 , 9 Additionally, institutional actions of feminine visibility such as “Where are they?” provide mitigation of gender inequality through the dissemination of the trajectories and careers of highly qualified professional scientists in the field of chemistry.…”
Section: A New Equilibrium State Is Possible!mentioning
confidence: 99%
“…On June 4, 2020, the world was still trying to adapt to the terrible effects of the escalating exponential spread of the pandemic contagion of the new Coronavirus SARS-CoV-2 (COVID-19), 1 3 as well as watching closely the developments of the outraged racial protests and violent people who called for justice in the face of the brutal murder of African American George Floyd by a white policeman in the United States of America (USA). 3 , 4 In this context of intense social tension, the international scientific community found itself completely perplexed and highly indignant when faced with inconceivably offensive, sexist, racist, and xenophobic statements, 3 written in the essay “‘Organic synthesis—Where now?’ Is 30 years old. A reflection on the current state of affairs”, published online by the prestigious Angewandte Chemie international edition of the German Chemical Society.…”
Section: Introductionmentioning
confidence: 99%
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“…With the goal of making everyone feel welcome,t he conference encouraged frank conversations,i ncluding open discussion of the challenges that face women and how these can be more pronounced for women of color and those of other marginalized groups.D iversity,e quity,a nd inclusion (DEI) were at the forefront of two workshops.T he first consisted of am oderated discussion of "Organic Chemistry:ARetrosynthetic Approach to aD iverse Field" with the aim of brainstorming actions one can take to promote DEI in the laboratory and workspace. [13] Thesecond workshop equipped participants with tools to address the issue of racism and its intersection with female identity." Allies Help Tu rn the Tide" was geared specifically toward those not part of ag iven marginalized group.P articipants were encouraged to reflect on the various identities they hold and consider how they might leverage their positions at work to amplify voices that may otherwise go unheard.…”
mentioning
confidence: 99%