Organic dragon fruits (Hylocereus undatus and Hylocereus polyrhizus) grown at the same edaphoclimatic conditions: Comparison of phenolic and organic acids profiles and antioxidant activities

Angonese, Mariana; Motta, Gabriel Emiliano; Farias, Natália Silva de; Molognoni, Luciano; Daguer, Heitor; Brugnerotto, Patrícia; Costa, Ana Carolina de Oliveira; Müller, Carmen Maria Olivera

doi:10.1016/j.lwt.2021.111924

Cited by 31 publications

(7 citation statements)

References 38 publications

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“…A total of 11 compounds were tentatively identified in the positive mode [M + H] + or [M + Na] + by comparing their m/z values of precursor ions with those in databases and the literature. Among this, six compounds were previously reported in H. undatus including homostachydrine [40], betaine, syringic acid [41], typhaneoside [41], rutin [40,41], and behenic acid [42]. All identified compounds were annotated by number and detailed in Table 2.…”

Section: Phytochemical Profiling Of H Undatus Extractmentioning

confidence: 99%

Hylocereus undatus extends lifespan and exerts neuroprotection in Caenorhabditis elegans via DAF-16 mediated pathway

Prasanth

Prasansuklab

Verma

et al. 2023

Nutrition and Healthy Aging

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BACKGROUND: Hylocereus undatus is a traditional medicinal plant known for its medicinal, nutritional and commercial uses. OBJECTIVE: To address the anti-aging and neuroprotective efficacies of fruit peel extracts of H. undatus using Caenorhabditis elegans model. METHODS: C. elegans (wild-type (N2), transgenic and mutant strains) were treated with H. undatus and monitored for lifespan and neuroprotection through physiological assays, fluorescence microscopy and qPCR analysis. LC-MS/MS analysis was performed to identify the phytochemicals present in the extract. Molecular docking studies were employed to identify the interaction mode of selected phytochemicals with Aβ, DAF-16 and SKN-1. RESULTS: The extract was able to extend the lifespan of C. elegans (N2), extend the lifespan and reduce paralysis of Aβ transgenic strains CL2006 and CL4176, suggesting its anti-aging and neuroprotective potential. The LC-MS/MS analysis revealed the presence of phytochemicals including homostachydrine, betaine, syringic acid, typhaneoside, rutin, and behenic acid. The extract could activate antioxidant mechanism, through SKN-1, which was evident in qPCR and transgenic strain LG333. These effects were mediated through DAF-16 pathway as the extract was able to upregulate the expression of daf-16 in N2, increase the nuclear localization of daf-16 in transgenic strain TJ356, and not able to significantly alter the lifespan of both DAF-2 and DAF-16 mutants, CB1370 and CF1038 respectively. Finally, in molecular docking approach, typhaneoside and rutin showed better binding affinity with SKN-1 and DAF-16 when compared to resveratrol and similar binding affinity with Aβ when compared to donepezil. CONCLUSION: Taken together, this study indicates that H. undatus activates anti-aging and neuroprotection via DAF-16 mediated pathway.

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Section: Phytochemical Profiling Of H Undatus Extractmentioning

confidence: 99%

Hylocereus undatus extends lifespan and exerts neuroprotection in Caenorhabditis elegans via DAF-16 mediated pathway

Prasanth

Prasansuklab

Verma

et al. 2023

Nutrition and Healthy Aging

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“…In contrast, H. undatus lacks betalain. Therefore, H. polyrhizus has an advantage over H. undatus, contributing to minerals, proteins, phenolics, and antioxidant properties [4][5][6][7]. Due to the gradual appreciation of betalain as a food additive and its potential medicinal value, based on biotechnologies, producing betalain has become a hot spot for researchers.…”

Section: Introductionmentioning

confidence: 99%

How Rhizosphere Microbial Assemblage Is Influenced by Dragon Fruits with White and Red Flesh

Zhou,

Chen,

Qiu

et al. 2024

Plants

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The synthesis of betalain using microorganisms is an innovative developmental technology, and the excavation of microorganisms closely related to betalain can provide certain theoretical and technical support to this technology. In this study, the characteristics of soil microbial community structures and their functions in the rhizospheres of white-fleshed dragon fruit (Hylocereus undatus) and red-fleshed dragon fruit (Hylocereus polyrhizus) were analyzed. The results show that the soil bacterial and fungal compositions in the rhizospheres were shaped differently between H. undatus and H. polyrhizus. Bacterial genera such as Kribbella and TM7a were the unique dominant soil bacterial genera in the rhizospheres of H. undatus, whereas Bradyrhizobium was the unique dominant soil bacterial genus in the rhizospheres of H. polyrhizus. Additionally, Myrothecium was the unique dominant soil fungal genus in the rhizospheres of H. polyrhizus, whereas Apiotrichum and Arachniotus were the unique dominant soil fungal genera in the rhizospheres of H. undatus. Moreover, TM7a, Novibacillus, Cupriavidus, Mesorhizobium, Trechispora, Madurella, Cercophora, and Polyschema were significantly enriched in the rhizospheres of H. undatus, whereas Penicillium, Blastobotrys, Phialemonium, Marasmius, and Pseudogymnoascus were significantly enriched in the rhizospheres of H. polyrhizus. Furthermore, the relative abundances of Ascomycota and Penicillium were significantly higher in the rhizospheres of H. polyrhizus than in those of H. undatus.

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“…The most commercialized species are Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose (Angonese et al, 2021), characterized by pulp and peel of intense red color. Recent research suggests that pitaya exibihit biological properties, including antioxidant, hypocholesterolemic (Holanda et al, 2021), cytotoxic (Paśko et al, 2021;Luo et al, 2014), antimicrobial, prebiotic (Choo et al, 2016 and anxiolytic activities (Lira et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

et al. 2023

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Pitaya is a rich source of bioactive compounds, such as polyphenols and betalains. Moreover, these compounds has been associated with reduced risk of type 2 diabetes mellitus. The aim of this study is to evaluate the effect of this fruit on glycemia and oxidative stress in aloxan-induced diabetic mice. Thus, considering that In the in vivo assays, the mice were divided into 5 groups (n = 6): (a) healthy group treated with water; (b) diabetic mice treated with metformin at 200 mg/kg body weight diluted in water; (c) untreated diabetic mice; (d) diabetic mice treated with pitaya at 200 mg/kg and (e) diabetic mice treated with pitaya at 400 mg/kg of body weight diluted in water. The results shows that pitaya was able significantly to reduce blood glucose (p < 0.05) (200 mg/kg); significantly reduce cholesterol (200 and 400 mg/kg) and significantly increase HDL-c (400 mg/kg) levels. In the oxidative stress experiment, Malondialdehyde levels in the liver were significantly reduced (p < 0.05) in the groups treated with pitaya, when compared to the other groups, suggesting lower lipid peroxidation. The consumption of pitaya reduced the blood glucose and cholesterol and increase the HDL, in addition, the lipid peroxidation -which is common in diabetic patients, was reduced.

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Organic dragon fruits (Hylocereus undatus and Hylocereus polyrhizus) grown at the same edaphoclimatic conditions: Comparison of phenolic and organic acids profiles and antioxidant activities

Cited by 31 publications

References 38 publications

Hylocereus undatus extends lifespan and exerts neuroprotection in Caenorhabditis elegans via DAF-16 mediated pathway

Hylocereus undatus extends lifespan and exerts neuroprotection in Caenorhabditis elegans via DAF-16 mediated pathway

How Rhizosphere Microbial Assemblage Is Influenced by Dragon Fruits with White and Red Flesh

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

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