Organic dyes in contemporary medicinal chemistry and biomedicine. I. From the chromophore to the bioimaging/bioassay agent

Yaneva, Zvezdelina; Ivanova, Donika; Nikolova, Nevena; Toneva, Monika

doi:10.1080/13102818.2022.2039077

Cited by 19 publications

(11 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Employing dyes in biology and medicine dates to the early 20th century. 39 By the 1970s, the synthetic dye ethidium bromide (4) had become a widely used nucleic acid intercalating agent. It was not surprising when studies soon began to appear demonstrating the use of D 2 O to further intensify the ethidium bromide fluorescence in binding to nucleic acids.…”

Section: Deuterium Amplification Of Dye Luminescencementioning

confidence: 99%

“…Natural dyes had been known for centuries, and synthetic dye chemistry had been initiated and rapidly advanced in the mid‐19th century. Employing dyes in biology and medicine dates to the early 20th century 39 . By the 1970s, the synthetic dye ethidium bromide ( 4 ) had become a widely used nucleic acid intercalating agent.…”

Section: Deuterium Amplification Of Dye Luminescencementioning

confidence: 99%

See 1 more Smart Citation

Luminescence enhancement by deuterium

Filer

2023

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

Created literally at the dawn of time, deuterium has been extremely valuable in so many chemistry roles. The subject of this review focuses on one deuterium application in particular: its enhancement of luminescence in many substances. After providing general overviews of both deuterium and luminescence, the early exploration of deuterium's effect on luminescence is described, followed by a number of specific topics. These sections include a discussion of deuterium‐influenced luminescence for dyes, proteins, singlet oxygen, and the lanthanide elements, as well as anomalous inverse deuterium luminescence effects. Future directions for this important research topic are also proposed, as well as a summary conclusion.

show abstract

Section: Deuterium Amplification Of Dye Luminescencementioning

confidence: 99%

Section: Deuterium Amplification Of Dye Luminescencementioning

confidence: 99%

Luminescence enhancement by deuterium

Filer

2023

Labelled Comp Radiopharmac

View full text Add to dashboard Cite

show abstract

“…Organic dyes are increasingly being explored as valuable components for bioimaging, disease diagnosis, photodynamic therapy, and photothermal therapy. , A large collection of organic dyes are also known for their pharmacological properties in the treatment of diseases including cancer, brain disorders, and different types of infections. , Hence, combining organic dye-based materials with a nanotechnology approach has been considered an emerging tool in nanomedicine . In this regard, different strategies have been studied for the encapsulation of dye molecules with polymers and other encapsulating agents to increase diagnosis efficiency and treatment modalities. , These encapsulated dye nanostructures showed the ability to carry dye substances, separating them from the outer environment followed by controlled release.…”

Section: Introductionmentioning

confidence: 99%

Study of PEG-b-PLA/Eudragit S100 Blends on the Nanoencapsulation of Indigo Carmine Dye and Application in Controlled Release

Ashkenazi,

Matsanov,

Nassar-Marjiya

et al. 2024

ACS Omega

View full text Add to dashboard Cite

A nanocapsule shell of poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-b-PLA) mixed with anionic Eudragit S100 (90/10% w/w) was previously used to entrap and define the self-assembly of indigo carmine (IC) within the hydrophilic cavity core. In the present work, binary blends were prepared by solution mixing at different PEG-b-PLA/Eudragit S100 ratios (namely, 100/0, 90/10, 75/25, and 50/50% w/w) to elucidate the role of the capsule shell in tuning the encapsulation of the anionic dye (i.e., IC). The results showed that the higher content of Eudragit S100 in the blend decreases the miscibility of the two polymers due to weak intermolecular interactions between PEG-b-PLA and Eudragit S100. Moreover, with an increase in the amount of Eudragit S100, a higher thermal stability was observed related to the mobility restriction of PEG-b-PLA chains imposed by Eudragit S100. Formulations containing 10 and 25% Eudragit S100 exhibited an optimal interplay of properties between the negative surface charge and the miscibility of the polymer blend. Therefore, the anionic character of the encapsulating agent provides sufficient accumulation of IC molecules in the nanocapsule core, leading to dye aggregates following the self-assembly. At the same time, the blending of the two polymers tunes the IC release properties in the initial stage, achieving slow and controlled release. These findings give important insights into the rational design of polymeric nanosystems containing organic dyes for biomedical applications.

show abstract

“…These advantages enable the accurate elucidation of optoelectronic properties based on minimal changes in functionality that otherwise would be convoluted. As such, the thorough understanding of discrete chromophores has made them useful in organic photovoltaic (OPV), , organic light-emitting diode (OLED), − redox, − and bioimaging − applications. One molecular scaffold that has emerged as a useful building block for conjugated materials is 1,4-dihydropyrrolo[3,2- b ]pyrrole (DHPP).…”

Section: Introductionmentioning

confidence: 99%

Relating Design and Optoelectronic Properties of 1,4-Dihydropyrrolo[3,2-b]pyrroles Bearing Biphenyl Substituents

Hawks,

Altman,

Faddis

et al. 2023

J. Phys. Chem. B

View full text Add to dashboard Cite

Understanding the influence of peripheral functionality on optoelectronic properties of conjugated materials is an important task for the continued development of chromophores for myriad applications. Here, π-extended 1,4-dihydropyrrolo[3,2b]pyrrole (DHPP) chromophores with varying electron-donating or electron-withdrawing capabilities were synthesized via Suzuki cross-coupling reactions, and the influence of functionality on optoelectronic properties was elucidated. First, chromophores display distinct differences in the UV−vis absorbance spectra measured via UV−vis absorbance spectroscopy in addition to changes in the onset of oxidation measured with cyclic voltammetry and differential pulse voltammetry. Solution oxidation studies found that variations in the electron-donating and -withdrawing capabilities result in different absorbance profiles of the radical cations that correspond to quantifiably different colors. In addition to fundamental insights into the molecular design of DHPP chromophores and their optoelectronic properties, two chromophores display high-contrast electrochromism, which makes them potentially compelling in electronic devices. Overall, this study represents the ability to fine-tune the optoelectronic properties of DHPP chromophores in their neutral and oxidized states and expands the understanding of structure−property relationships that will guide the continued development of DHPP-based materials.

show abstract

Organic dyes in contemporary medicinal chemistry and biomedicine. I. From the chromophore to the bioimaging/bioassay agent

Cited by 19 publications

References 80 publications

Luminescence enhancement by deuterium

Luminescence enhancement by deuterium

Study of PEG-b-PLA/Eudragit S100 Blends on the Nanoencapsulation of Indigo Carmine Dye and Application in Controlled Release

Relating Design and Optoelectronic Properties of 1,4-Dihydropyrrolo[3,2-b]pyrroles Bearing Biphenyl Substituents

Contact Info

Product

Resources

About