2020
DOI: 10.1186/s12906-020-2858-0
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Organic extracts from Cleome droserifolia exhibit effective caspase-dependent anticancer activity

Abstract: Background: This study investigated the anticancer potential of the medicinal herb, Cleome droserifolia (CD), a local plant of the Arabian Peninsula. C. droserifolia is traditionally known for its rubefacient, anti-diabetic, anti-oxidant, and anti-inflammatory properties. Methods: Organic fractions of the aerial parts of Cleome droserifolia harvested from the Arabian Peninsula were tested in human breast and cervical cancer cell lines for their anticancer potential. This was accomplished by using biochemical a… Show more

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Cited by 12 publications
(7 citation statements)
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“…The caspase-3 and caspase-9 enzyme activities, markers of apoptosis induction ( Elmore, 2007 ) was measured in MCF-7 cells exposed to 250–1000 μg/mL of KLH for 24 h. The results showed that KLH treatment significantly increased the level of caspase-3 and -9 enzyme activities by up to 2.8- and 2.5-fold at 1000 μg/mL, respectively. These results are consistent with the previous reports that showed plant extracts or natural products can increase the enzyme activities which can induce caspase-dependent apoptosis in human breast cancer cells ( Panicker et al, 2020 ) as well as in other cell types ( Abdullah et al, 2017 ).…”
Section: Discussionsupporting
confidence: 93%
“…The caspase-3 and caspase-9 enzyme activities, markers of apoptosis induction ( Elmore, 2007 ) was measured in MCF-7 cells exposed to 250–1000 μg/mL of KLH for 24 h. The results showed that KLH treatment significantly increased the level of caspase-3 and -9 enzyme activities by up to 2.8- and 2.5-fold at 1000 μg/mL, respectively. These results are consistent with the previous reports that showed plant extracts or natural products can increase the enzyme activities which can induce caspase-dependent apoptosis in human breast cancer cells ( Panicker et al, 2020 ) as well as in other cell types ( Abdullah et al, 2017 ).…”
Section: Discussionsupporting
confidence: 93%
“…These results suggest that the AG-ME-induced MCF-7 cell death is caspase-dependent. The caspase-dependent anticancer activity of plant extract has also been previously reported in MCF-7 [ 64 ]. A large number of phytoconstituents present in methanolic extracts of A. graveolens have already been reported [ 65 ]; therefore, we assume that the anticancer efficacies of AG-ME observed in present investigation might be due to the existence of phytocompounds in it.…”
Section: Discussionmentioning
confidence: 83%
“…Table (3 The results also revealed that the percent of cell death is time-dependent increased with time from 24hr. to 72hr (35) . As shown in Figure (5) all the tested compounds show considerable variation in responsiveness to cell death compared to standard.…”
Section: Results Of Cytotoxicity Studiesmentioning
confidence: 97%