Organic extracts from Indigofera suffruticosa leaves have antimicrobial and synergic actions with erythromycin against Staphylococcus aureus

Santos, Alex Maurício Garcia; Araújo, Tiago Ferreira da Silva; Silva, Luís Cláudio Nascimento da; Silva, Cleideana Bezerra da; Oliveira, Antônio Fernando Morais de; Araújo, Janete Magalí de; Correia, Maria Tereza dos Santos; Lima, Vera Lúcia de Menezes

doi:10.3389/fmicb.2015.00013

Cited by 31 publications

(24 citation statements)

References 36 publications

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“…Biological control is becoming increasingly important in integrated pest management programs, especially when discussing integrated production towards sustainable agriculture. Many plant and plant extracts have been reported to have antimicrobial properties against plant pathogenic fungi (Sharmin et al, 2013;Vergnes, 2014;Akladious et al, 2015;Santos et al, 2015). Allamanda species extract has been proved as effective in controlling plant pathogenic fungi (Islam, 2004;Ravikumar et al, 2013;Basar et al, 2011;Mone et al, 2013;Barros et al, 2015;Brito et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

Oliveira¹,

Almeida²,

Silva³

et al. 2019

JAS

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This research aims to analyze the effect of the extract from a native plant from Caatinga, Allamanda blanchetti, in the induction of resistance mechanisms in a sugarcane variety smut-susceptible. Initially, it carried out a phytochemical analysis to know the main plant compounds used in this study. Diverse chemicals content in ethanolic extract from A. blanchetii were detected by thin-layer chromatography (TLC). Flavonoids, were more abundant compounds following by terpenes, stereroids and saponins. Under greenhouse conditions the sugarcane plants, SP-791011 (smut-susceptible), were sprayed with extracts from A. blanchetti extracted at cold at concentrations of 1000 ppm and acilbenzolar-S-metil (ASM) (100 mg/L). Leaves were collected at 0, 24 and 48 hours after spraying and used in the RT-PCR analysis for to identify the defense gene expression. Change in gene expression were observed in the different treatments, especially in the expression of pathogenesis-related (PR) genes. The extract of A. blanchetti induced an increase in the glucanase expression and was more effective than ASM inducer. SNPR1 gene show increased in the two treatment. The results indicate that A. blanchetti extracts was able to activate the resistance mechanism as observed in resistant plants. This paper is the first report about the use of Caatinga natural plant extracts inducing resistance genes against Sporisorium scitamineum in sugarcane susceptible genotype.

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Section: Discussionmentioning

confidence: 99%

“…2013;Savithramma et al, 2013). Several reports described the native plant extracts potential to control plant diseases (Barros et al, 2015;Dos Santos et al, 2015;Peixinho et al, 2017). Brazil´s flora species present high potential as a source of bioactive substances for control of plant diseases.…”

Section: Introductionmentioning

confidence: 99%

Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

Oliveira¹,

Almeida²,

Silva³

et al. 2019

JAS

Self Cite

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“…drymifolia), así como su perfil fitoquímico funcional. (Motamedi et al, 2014;Bezerra dos Santos et al, 2015, Taylor et al, 2005. La actividad bactericida puede deberse en parte a la presencia de saponinas; estos compuestos tienen la capacidad de romper las membranas de los microorganismos modificando la tensión superficial del medio extracelular (Nassiri y Hosseinzadeh, 2008).…”

Section: Discusión Y Conclusiónunclassified

Inhibición de la expresión del sistema agr de Staphylococcus aureus resistente a meticilina mediante el uso de polifenoles totales de hojas de aguacate mexicano (Persea americana var. drymifolia)

Moreno¹,

Ramos

Martínez-Ávila

et al. 2017

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Resumen IntroducciónLa resistencia a los antibióticos por parte de las bacterias está provocando gran impacto negativo en la salud humana y en la producción animal. Actualmente, Staphylococcus aureus es considerada dentro de los seis principales grupos bacterianos con mayores reportes de aparición de resistencia a nivel mundial. Por otro lado, durante décadas las plantas de uso medicinal han sido fuente importante de compuestos bactericidas; sin embargo, también se ha empezado a documentar otras moléculas con otros mecanismos antimicrobianos, como es la inhibición de la percepción de quórum (anti-percepción de quórum (APQ)). En la medicina tradicional mexicana las hojas de aguacate mexicano (Persea americana var drymifolia) han sido empleadas para tratar diversos padecimientos que involucran infecciones bacterianas, por lo que es factible contenga compuestos que posean efectos antioxidantes, bactericidas y APQ, que ayuden a combatir las infecciones de cepas resistentes. De tal manera, que el objetivo de esta investigación fue determinar el efecto de los polifenoles totales de las hojas de Persea americana var.drymifolia y su actividad APQ sobre cepas de S. aureus resistentes a meticilina (MRSA). MétodosSe obtuvieron los polifenoles presentes en las hojas de 18 cultivares de aguacate mexicano mediante extracción asistida por ultrasonido y fueron purificados en una columna de amberlita. Discusión y ConclusiónLos polifenoles extraídos de las hojas de aguacate mexicano, exhiben principalmente actividad bactericida, pero también inhiben la expresión de genes asociados a la percepción de quórum de cepas de S. aureus MRSA. De igual manera, presentan una buena actividad antioxidante, lo que en conjunto puede ayudar a contrarrestar las infecciones con cepas resistentes de manera más eficiente. Por lo tanto, las hojas de aguacate mexicano son una fuente importante de metabolitos antioxidantes, bactericidas y APQ. Abstract IntroductionBacteria resistant to antibiotics are important due to great negative impact on both, human health and animal production. Currently, Staphylococcus aureus is considered one of the six main bacterial groups with the highest reports of emergence resistance around the world. On the other hand, for decades the use of medicinal plants, have been important source of bactericidal compounds; however, there are other kind of molecules with many antimicrobial mechanisms such as phenolic compounds; which as antiquorum sensing (AQS) effect. In the mexican traditional medicine the creole avocado leaves (Persea americana var drymifolia), have been used to treat various diseases involving bacterial infections. In this sense, it is possible to find compounds with antioxidant, bactericidal and AQS effects, which could help to eradicate

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“…Development of new safe and effective therapeutic strategies is highly demanded to overcome drug-resistant bacterial strains and adverse side effects. One such strategy is combination of different antibiotics or with plant derived natural products (Coutinho et al, 2009 ; Bezerra Dos Santos et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats

Zhou

Pan

et al. 2017

Front. Cell. Infect. Microbiol.

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Osteomyelitis is commonly caused by Staphylococcus aureus. Both erythromycin and curcumin can suppress S. aureus growth, but their roles in osteomyelitis are barely studied. We aim to explore the activities of erythromycin and curcumin against chronical osteomyelitis induced by methicillin-resistant S. aureus (MRSA). Chronicle implant-induced osteomyelitis was established by MRSA infection in male Wistar rats. Four weeks after bacterial inoculation, rats received no treatment, erythromycin monotherapy, curcumin monotherapy, or erythromycin plus curcumin twice daily for 2 weeks. Bacterial levels, bone infection status, inflammatory signals and side effects were evaluated. Rats tolerated all treatments well, with no death or side effects such as, diarrhea and weight loss. Two days after treatment completion, erythromycin monotherapy did not suppress bacterial growth and had no effect in bone infection, although it reduced serum pro-inflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6. Curcumin monotherapy slightly suppressed bacterial growth, alleviated bone infection and reduced TNF-α and IL-6. Erythromycin and curcumin combined treatment markedly suppressed bacterial growth, substantially alleviated bone infection and reduced TNF-α and IL-6. Combination of erythromycin and curcumin lead a much stronger efficiency against MRSA induced osteomyelitis in rats than monotherapy. Our study suggests that erythromycin and curcumin could be a new combination for treating MRSA induced osteomyelitis.

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Organic extracts from Indigofera suffruticosa leaves have antimicrobial and synergic actions with erythromycin against Staphylococcus aureus

Cited by 31 publications

References 36 publications

Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

Extracts From Leaves of Allamanda blanchetti Inducing Mechanism of Defense to Diseases in Sugarcane

Inhibición de la expresión del sistema agr de Staphylococcus aureus resistente a meticilina mediante el uso de polifenoles totales de hojas de aguacate mexicano (Persea americana var. drymifolia)

Combination of Erythromycin and Curcumin Alleviates Staphylococcus aureus Induced Osteomyelitis in Rats

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