Organic fluorophores with high photostability and strong emission in both solution and solid state

Shi, Guowei; Ge, Heng; Zhang, Liqing; Li, Yongchao; Cui, Renle; Wayment, Lacey J.; Ge, Yanqing; Zhang, Wei

doi:10.1016/j.jlumin.2022.119447

Journal of Luminescence

2023

DOI: 10.1016/j.jlumin.2022.119447

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Organic fluorophores with high photostability and strong emission in both solution and solid state

Guowei Shi

Heng Ge²,

Liqing Zhang³

et al.

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Cited by 8 publications

References 34 publications

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Red‐emissive Dual‐state Fluorogenic Probe for Wash‐free Imaging of Lipid Droplets in Living Cells and Fatty Liver Tissues

Wang

Zhang

et al. 2023

Chemistry An Asian Journal

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Lipid droplet (LD) dysfunction can result in various diseases, such as nonalcoholic fatty liver disease. Imaging agents built on dual-state emission (DSE) molecules that fluoresce in both dilute solutions and the aggregated state are receiving attention as this type of probe could provide bright fluorescence signals at variable concentrations, avoiding false signal readout caused by the concentration fluctuation in living systems. Herein, we identified a red emissive molecule featuring DSE, from three newly synthe-sized molecules, for specific detection of LDs in live cells. The bioimaging abilities have been well confirmed by optical spectroscopies, theoretical calculations, cell experiments, as well as animal studies. The DSE probe is effective for LD detection at concentrations ranging from 1 μM to 100 μM while retaining high brightness and signal fidelity. This study provides a knowledge base for the future design of DSEactive fluorescent probes for understanding LD-related diseases.

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Red‐emissive Dual‐state Fluorogenic Probe for Wash‐free Imaging of Lipid Droplets in Living Cells and Fatty Liver Tissues

Wang

Zhang

et al. 2023

Chemistry An Asian Journal

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One‐Pot Synthesis of 1, 2‐Dihydro [1,2,4] Triazinium Salt by Copper‐Assisted Unprecedented Cyclization Reaction: Applications in DNA and Protein Interaction Studies

Maji,

Yadav,

Sharma

et al. 2024

ChemPlusChem

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Copper catalyzed intramolecular annulation of 2‐((2benzylidene‐1‐phenylhydrazineyl)methyl)pyridine derivatives was described. It was found that Cu(II) is reduced under the reaction condition to Cu(I). Synthesized 1, 2‐dihydro [1,2,4] triazinium salt showed fluorescence activity in solid state. On treating with base, an instant increase in fluorescence was observed. A detailed physicochemical assessment underscored the robust DNA‐binding prowess of the [1,2,4] triazinium cationic species (C1‐C3) via intercalative mechanisms. Notably, binding assays with BSA accentuated the heightened nucleic acid affinity of these cationic species.

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A dual-state emission luminogen for lipid droplet imaging and photodynamic therapy

Lei,

Ji,

Xiang

et al. 2024

Bioorganic Chemistry

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Organic fluorophores with high photostability and strong emission in both solution and solid state

Cited by 8 publications

References 34 publications

Red‐emissive Dual‐state Fluorogenic Probe for Wash‐free Imaging of Lipid Droplets in Living Cells and Fatty Liver Tissues

Red‐emissive Dual‐state Fluorogenic Probe for Wash‐free Imaging of Lipid Droplets in Living Cells and Fatty Liver Tissues

One‐Pot Synthesis of 1, 2‐Dihydro [1,2,4] Triazinium Salt by Copper‐Assisted Unprecedented Cyclization Reaction: Applications in DNA and Protein Interaction Studies

A dual-state emission luminogen for lipid droplet imaging and photodynamic therapy

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