Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

Radev, Lachezar; Hristov, Vladimir; Fernandes, Maria Helena; Salvado, Isabel M. Miranda

doi:10.2478/s11532-009-0142-8

Cited by 12 publications

(7 citation statements)

References 45 publications

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“…Similar can be said on A-W/silk fibroin biocomposites [ 970 ]. Other examples comprise wollastonite-reinforced HA/Ca polycarboxylate [ 971 ], glass-reinforced HA/polyacrylate [ 972 ], as well as collagen- [ 973 ] and gelatin- [ 974 ] calcium phosphate silicate/wollastonite biocomposites.…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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“…glass-reinforced HA/polyacrylate 1068 as well as collagen 1069 and gelatin 1070 calcium phosphate silicate/wollastonite biocomposites. HA/glass biocomposites can be prepared by simple sintering of appropriate HA/glass powder mixtures.…”

Section: Injectable Bone Substitutes (Ibs)mentioning

confidence: 99%

Biocomposites and hybrid biomaterials based on calcium orthophosphates

Dorozhkin¹

2011

Biomatter

156

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“…In addition, deposition of HAp nanoapatites on gelatin molecules imitating microstructures of natural bone has shown to provide superior osteogenesis and resorptive potential to the sintered HAp. The nanocomposites are demonstrated to promote a favorable environment for cell attachment and proliferation, which enhances potential clinical applications [14,15].…”

Section: Introductionmentioning

confidence: 97%

In-situ hybridization of calcium silicate and hydroxyapatite-gelatin nanocomposites enhances physical property and in vitro osteogenesis

Chiu

Lee

Chen

et al. 2015

J Mater Sci: Mater Med

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Low mechanical strengths and inadequate bioactive material-tissue interactions of current synthetic materials limit their clinical applications in bone regeneration. Here, we demonstrate gelatin modified siloxane-calcium silicate (GEMOSIL-CS), a nanocomposite made of gelatinous hydroxyapatite with in situ pozzolanic formation of calcium silicate (CS) interacting among gelatin, silica and Calcium Hydroxide (Ca(OH)2). It is shown the formation of CS matrices, which chemically bonds to the gelatinous hydroxyapatite, provided hygroscopic reinforcement mechanism and promoted both in vitro and in vivo osteogenic properties of GEMOSIL-CS. The formation of CS was identified by Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction. The interfacial bindings within nanocomposites were studied by FTIR and thermogravimetric analysis. Both gelatin and CS have been found critical to the structure integrity and mechanical strengths (93 MPa in compressive strength and 58.9 MPa in biaxial strength). The GEMOSIL-CS was biocompatible and osteoconductive as result of type I collagen secretion and mineralized nodule formation from MC3T3 osteoblasts. SEM and TEM indicated the secretion of collagen fibers and mineral particles as the evidence of mineralization in the early stage of osteogenic differentiation. In vivo bone formation capability was performed by implanting GEMOSIL-CS into rat calvarial defects for 12 weeks and the result showed comparable new bone formation between GEMOSIL-CS group (20%) and the control (20.19%). The major advantage of GEMOSIL-CS composites is in situ self-hardening in ambient or aqueous environment at room temperature providing a simple, fast and cheap method to produce porous scaffolds.

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Organic/inorganic bioactive materials part IV: In vitro assessment of bioactivity of gelatin-calcium phosphate silicate/wollastonite hybrids

Cited by 12 publications

References 45 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Biocomposites and hybrid biomaterials based on calcium orthophosphates

In-situ hybridization of calcium silicate and hydroxyapatite-gelatin nanocomposites enhances physical property and in vitro osteogenesis

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