Organic-inorganic double networks as highly permeable separation membranes with a chiral selector for organic solvents

Milovanovic, Marko; Tabakoglu, Furkan; Saki, Furkan; Pohlkoetter, Elpida; Buga, Duygu; Brandt, Volker; Tiller, Joerg C.

doi:10.1016/j.memsci.2022.121190

Cited by 10 publications

(5 citation statements)

References 90 publications

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“…In 2023, to produce membranes with good enantioselectivity, stiffness and strength, Milovanovic et al innovatively utilized alkaline phosphatase to calcify a cross-linked ( R / S )- N -(hydroxybutan-2-yl)amide hydrogel membrane in a buffer to establish an organic–inorganic double network. 334 In this as-mineralized membrane, swelling in methanol could expand the pores occupied by polymers due to the good stretching ability of the inorganic calcium framework. Also, exposure to toluene could partially collapse the organic phase in the inorganic phase and in situ produce cavities.…”

Section: Membrane Resolution Methodsmentioning

confidence: 99%

Strategies for chiral separation: from racemate to enantiomer

Sui,

Wang,

Wang

et al. 2023

Chem. Sci.

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Section: Membrane Resolution Methodsmentioning

confidence: 99%

Strategies for chiral separation: from racemate to enantiomer

Sui,

Wang,

Wang

et al. 2023

Chem. Sci.

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“…The designed membrane showed good separation of R- and S-naproxen. It also possessed excellent mechanical stability and high solute permeabilities . In spite of the increasing amount of research in membranes for enantioseparation applications, their use is still limited to small scales for some exploratory projects about pharmaceuticals and amino acids .…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

“…It also possessed excellent mechanical stability and high solute permeabilities. 212 In spite of the increasing amount of research in membranes for enantioseparation applications, their use is still limited to small scales for some exploratory projects about pharmaceuticals and amino acids. 209 More research is needed in this field to obtain membranes that are practical to use on larger scales and add value for industrial applications.…”

Section: Challenges and Future Perspectivesmentioning

confidence: 99%

Organic Solvent Nanofiltration in Pharmaceutical Applications

Xiao,

Feng,

Goundry

et al. 2024

Org. Process Res. Dev.

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Separation and purification in organic solvents are indispensable procedures in pharmaceutical manufacturing. However, they still heavily rely on the conventional separation technologies of distillation and chromatography, resulting in high energy and massive solvent consumption. As an alternative, organic solvent nanofiltration (OSN) offers the benefits of low energy consumption, low solid waste generation, and easy scale-up and incorporation into continuous processes. Thus, there is a growing interest in employing membrane technology in the pharmaceutical area to improve process sustainability and energy efficiency. This Review comprehensively summarizes the recent progress (especially the last 10 years) of organic solvent nanofiltration and its applications in the pharmaceutical industry, including the concentration and purification of active pharmaceutical ingredients, homogeneous catalyst recovery, solvent exchange and recovery, and OSN-assisted peptide/oligonucleotide synthesis. Furthermore, the challenges and future perspectives of membrane technology in pharmaceutical applications are discussed in detail.

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“…At the same time, the chiral membrane shows excellent permanent selectivity. In addition, Tiller's group [ 129 ] formed inorganic frames within organic polymer membranes, which greatly improved the stiffness and strength of the membranes ( Figure ). This organic–inorganic dual network membrane has high solute permeability and selectivity.…”

Section: Key Issues Facing Enantioseparation Membranesmentioning

confidence: 99%

Enantioseparation Membranes: Research Status, Challenges, and Trends

Cheng

Pei

et al. 2023

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The purity of enantiomers plays a critical role in human health and safety. Enantioseparation is an effective way and necessary process to obtain pure chiral compounds. Enantiomer membrane separation is a new chiral resolution technique, which has the potential for industrialization. This paper mainly summarizes the research status of enantioseparation membranes including membrane materials, preparation methods, factors affecting membrane properties, and separation mechanisms. In addition, the key problems and challenges to be solved in the research of enantioseparation membranes are analyzed. Last but not least, the future development trend of the chiral membrane is expected.

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Organic-inorganic double networks as highly permeable separation membranes with a chiral selector for organic solvents

Cited by 10 publications

References 90 publications

Strategies for chiral separation: from racemate to enantiomer

Strategies for chiral separation: from racemate to enantiomer

Organic Solvent Nanofiltration in Pharmaceutical Applications

Enantioseparation Membranes: Research Status, Challenges, and Trends

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