Organic–inorganic nanohybrids for fluorescence, photoacoustic and Raman bioimaging

Sreejith, Sivaramapanicker; Hương, Trần Thị Mai; Borah, Parijat; Zhao, Yanli

doi:10.1007/s11434-015-0765-4

Cited by 42 publications

(27 citation statements)

References 82 publications

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“…ESEM is an imaging technique affording higher resolution than conventional optical microscope, which was used for further investigation of direct interaction or possible penetration of gold nanomaterials with human keratinocytes at high spatial resolution of tens‐of‐nanometer scale . There is weak interaction between gold nanosheets and human keratinocytes as shown in ESEM images of Figure .…”

Section: Resultsmentioning

confidence: 99%

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

Cao

Tang

et al. 2016

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Establishment of analytical methods of engineered nanomaterials in consumer products for their human and environmental risk assessment becomes urgent for both academic and industrial needs. Owing to the difficulties and challenges around nanomaterials in complex media, proper chemical separation and biological assays of nanomaterials from nanoproducts needs to be firstly developed. Herein, a facile and rapid method to separate and analyze gold nanomaterials in cosmetics is reported. Gold nanomaterials are successfully separated from different facial or eye creams and their physiochemical properties are analyzed by quantitative and qualitative state-of-the art techniques with high sensitivity or high spatial resolution. In turn, a protocol including quantification of gold by inductively coupled plasma mass spectrometry and thorough characterization of morphology, size distribution, and surface property by electron microscopes, atomic force microscope, and X-ray photoelectron spectroscope is developed. Subsequently, the preliminary toxicity assessment indicates that gold nanomaterials in cosmetic creams have no observable toxicity to human keratinocytes even after 24 h exposure up to a concentration of 200 μg mL . The environmental scanning electron microscope reveals that gold nanomaterials are mostly attached on the cell membrane. Thus, the present study provides a full analysis protocol for toxicity assessment of gold nanomaterials in consumer products (cosmetic creams).

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Section: Resultsmentioning

confidence: 99%

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

Cao

Tang

et al. 2016

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“…In recent years, NIR fluorescence cancer imaging is a growing field for both preclinical and clinical application to cancer patients because of high sensitivity and specificity, operational simplicity, real-time display, safety and cost effectiveness. As a result, the combination of NIR fluorescence and MR imaging shows great promise in enhancement of precisely diagnosis 41 - 44 . Therefore, we have pressing need for the development of nanoparticles for targeting cancer PTT combining fluorescence and magnetic resonance imaging.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

Yang

Jing

et al. 2017

Theranostics

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A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS2-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field. Both NIR fluorescence and MR imaging in vivo proved high accumulation of the nanoagent at tumor site due to its excellent CD44 receptor/magnetic dual targeting capability. After intravenous injection of the nanoagent and treatment of external magnetic field, the tumor in nude mice was efficiently ablated upon NIR laser irradiation and the tumor growth inhibition was more than 89.95%. Such nanotheranostic agent is of crucial importance for accurately identifying the size and location of the tumor before therapy, monitoring the photothermal treatment procedure in real-time during therapy, assessing the effectiveness after therapy.

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“…This further proves that the PVP plays an important role in promoting the heterogeneous growth of gold shell, achieving the easy preparation of gold nanoshells in a wide range of mass ratio of SNs and Au. Biocompatibility is another crucial factor in medical examination and treatment [26][27][28][29][30][31]. We further study the in vivo biocompatibility of PVP-GSNs using healthy ICR mice as a model according to a standard protocol.…”

Section: Resultsmentioning

confidence: 99%

High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity

Tan

et al. 2016

Science Bulletin

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Organic–inorganic nanohybrids for fluorescence, photoacoustic and Raman bioimaging

Cited by 42 publications

References 82 publications

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

Gold Nanomaterials in Consumer Cosmetics Nanoproducts: Analyses, Characterization, and Dermal Safety Assessment

Hyaluronic Acid Conjugated Magnetic Prussian Blue@Quantum Dot Nanoparticles for Cancer Theranostics

High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatiblity

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