Organic Lead Toxicology

Patočka, Jiří; Cerný, K

doi:10.14712/18059694.2017.26

Cited by 17 publications

(5 citation statements)

References 38 publications

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“…Exposure of human body to toxic substances may affect multiple organ systems and cause morphological, biochemical and physiological changes, including impaired kidney function and haematological disorders [36][37][38]. Hematopoietic system is the main target of some drug which adversely affects heme synthesis enzymes, the normal production rate of erythropoietin, normal range, morphology and distribution of various blood cells [39,40].…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Gentamicin-Induced Renal Damage in Rats by Ethanol Extract of the Whole Plant Biophytum Sensitivum (Linn.) Dc

Abhirama

Raju³

2018

Int J Pharm Pharm Sci

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Objective: Present study was undertaken to investigate the nephroprotective activity of whole plant ethanol extract of Biophytum sensitivum Linn. DC (B. sensitivum; EEBS) on gentamicin induced-nephrotoxicity in Wistar albino rats.Methods: Animals were divided into five groups, containing six animals in each. Gentamicin (GM) 100 mg/kg/d; i. p., was given to all groups except normal control to induce nephrotoxicity for a period of 8 d in rats. Animals in Group I served as control and Group II as GM-treated or nephrotoxic control. Group III received standard quercetin (50 mg/kg; p. o.); group IV received EEBS (250 mg/kg; p. o.) and group V received EEBS (500 mg/kg; p. o.), for 8 d. Several renal functional tests and injury markers such as a change in body weight, water intake, urine volume and pH, urinary levels of total protein, albumin, sodium, potassium, calcium and magnesium were measured. Different hematological parameters including, red blood cells (RBC), hemoglobin (Hb), packed cell volume (PCV), mean corpuscular haemoglobin (MCH), white blood corpuscles (WBC), lymphocyte, monocyte, polymorphs and eosinophil were also analyzed. Results:The results revealed that co-administration of EEBS at 250 and 500 mg/kg significantly reduced the urinary excretion of total protein (4.05±0.04, 3.53±0.05 g/dl), albumin (0.81±0.08, 0.71±0.00 g/dl), calcium (8.05±0.05, 7.81±0.06 mg/dl) and magnesium (0.79±0.05, 0.77±0.06 mg/dl) respectively. EEBS treatment in group IV and V animals produced a significant increase in body weight (2.58±0.17, 2.52±0.22 g), water intake (17.35±0.82, 17.87±0.86 ml/24 h) urine output (7.24±0.15, 7.88±0.08 ml/24 h), compared to animals in group II. Co-therapy with both doses of extracts also showed significant increase in RBC (6.85±0.31, 7.10±0.43 Conclusion: This study substantiated and confirmed the ethnomedical usefulness of B. sensitivum as a nephroprotective and antioxidant agent.) and polymorphs (14.19±0.20, 14.05±0.11%) levels were found to be significantly reduced respectively in animals than those in toxic control group.

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Section: Discussionmentioning

confidence: 99%

Amelioration of Gentamicin-Induced Renal Damage in Rats by Ethanol Extract of the Whole Plant Biophytum Sensitivum (Linn.) Dc

Abhirama

Raju³

2018

Int J Pharm Pharm Sci

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“…Inorganic lead is defined as lead oxides, metallic lead, and lead salts [20]. The organic lead compounds include the tetra-alkyl lead compounds mainly tetraethyl lead and tetramethyl lead which have been incorporated into gasoline as anti-knock additives [21]. Lead toxicity leads to various pathophysiological conditions.…”

Section: Occupationalmentioning

confidence: 99%

Lead: Tiny but Mighty Poison

et al. 2017

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The documentation of lead toxicity (plumbism) dates back to the times when man learnt its various applications. This versatile heavy metal is non-degradable and its ability to get accumulated in the body that goes undiagnosed, makes it a serious environmental health hazard. Lead is now known to affect almost every organ/tissue of the human body. With irreversible effects on neurobiological development of young children and foetus, its toxicity has lasting implications on the human life. Outlining the symptoms, diagnosis and treatment therapy for lead poisoning, the present review elaborates the pathophysiological effects of lead on various organs. This will be of immense help to the health professionals so as to inculcate a better understanding of the lead poisoning which otherwise is asymptomatic. With chelation therapy being the classic path of treatment, new strategies are being explored as additive/adjunct therapy. It is now understood that lead toxicity is completely preventable. In this regard significant efforts are in place in the developed countries whereas much needs to be done in the developing countries. Spreading the awareness amongst the masses by educating them and reducing the usage of lead following stricter industry norms appears to be the only roadmap to prevent lead poisoning. Efforts being undertaken by the Government of India and other organisations are also mentioned.

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“…Zcela jsme se však olova v životním prostředí nezbavili. Organické sloučeniny olova představují větší riziko pro zdraví lidí než anorganické sloučeniny olova (Patočka, 2008). Zemědělská půda obsahuje průměrně 10 mg Pb/kg, např.…”

Section: Těžké Kovyunclassified

Environmental health: acute problems

Patočka¹,

Zölzer²

2013

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EnVIRonmEntální zdRaVí: naléhaVé pRoblémy Environmental health: acute problems Jiří patočka, Friedo zölzer Jihočeská univerzita v Českých Budějovicích, Zdravotně sociální fakulta, katedra radiologie, toxikologie a ochrany obyvatelstva Summary At present, the definition of the human health is not limited only to the absence of diseases or corporal disorders, it is interpreted as the state of complete corporal, mental and social well-being. To reach such a state is not easy though, and it is quite impossible to be reached without providing such environmental quality, where the concentration levels of pollution caused by human activity do not impact significantly human health, or rather they do not represent any unacceptable risks for the human health. Researches in the latest years clearly show the causal connection between human health and environmental pollution, and the impossibility to improve the health of the population without improving the environment where people live, work, rest and perform a plenty of other activities. The newly being constituted discipline of "environmental health" should deal not only with the studies of the particular environmental factors, that have a positive or a negative impact on human health, but should also deal with the evaluation of health risks. This is meant to be especially the assessment of the level and seriousness of the load the population exposed to the risk factors of the environment, work conditions and lifestyle faces. At present, there exist several exigent problems that biomedicine due to its relation to the environment should deal with, and that are related to the global environmental problems as well as to local problems.

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Organic Lead Toxicology

Cited by 17 publications

References 38 publications

Amelioration of Gentamicin-Induced Renal Damage in Rats by Ethanol Extract of the Whole Plant Biophytum Sensitivum (Linn.) Dc

Amelioration of Gentamicin-Induced Renal Damage in Rats by Ethanol Extract of the Whole Plant Biophytum Sensitivum (Linn.) Dc

Lead: Tiny but Mighty Poison

Environmental health: acute problems

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