Swine wastewater contains high concentrations of organic compounds, nutrients (nitrogen and phosphorus), heavy metals, and residual antibiotics, amongst others, that have negative impacts on the water environment. The main aim of this work was to remove nutrients from anaerobically digested swine wastewater using an intermittent cycle extended aeration system (ICEAS). The effects of operational parameters such as cycle time, organic loading rate, C/N ratio, and aeration/mixing ratio on the pollutant removal efficiencies of ICEAS were studied and compared with the performance of a conventional sequencing batch reactor (SBR). The following optimal conditions were obtained: cycle time, 6 h; organic loading rate, 0.86 kg COD m −3 day −1 ; C/N ratio, 2.49-2.82; and aeration/ mixing ratio, 1.57. The pH was maintained in the range of 6.0-8.0. The total organic carbon (TOC), total nitrogen (TN), ammonium (NH 4 +), total phosphorus (TP), and color removal efficiencies of ICEAS were higher than those of the conventional SBR, with removal