The chapter reviews recent progress of two-wave mixing in a novel organic-inorganic hybrid structures that combine essential properties as large anisotropy and strong birefringence, typical for organics with the excellent photosensitivity and photoconductivity of inorganics into single, compact devices. Depending on the designed assembly and operation principle, the proposed structures can record dynamic holographic gratings at Raman-Nath or Bragg regimes of diffraction, respectively. When the two beams interact in a structure based on a photoconductive material and birefringent layer (usually liquid crystal), the beam coupling with high amplification values occur in a liquid crystal layer, however, the fringe period of recorded holograms is limited to few μm scale. In contrast, when the two beams interact in a structure based on a photorefractive material and birefringent layer, the beam-coupling occurs in both composites, due to the surface activated photorefractive effect. The prime significance of the later structure is the ability to act as a holographic grating at Bragg regime allowing sub-micron spatial resolution. Moreover they are easy and simple to fabricate where the processes are all optically controlled. The above examples open scenarios to design new devices that meet the latest requirements of 3D display technologies and optical information processing.