Organic selenium supplementation increased selenium concentrations in ewe and newborn lamb blood and in slaughter lamb meat compared to inorganic selenium supplementation

Steen, Arvid; Strøm, Turid; Bernhoft, Aksel

doi:10.1186/1751-0147-50-7

Cited by 25 publications

(16 citation statements)

References 20 publications

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“…The increase in blood Se was greater in OSe (19.5%) than in MSe (1.5%) gilts (treatment x time for OSe vs. MSe, P < 0.01; Figure 1). This effect of Se source on blood Se concentration is consistent with findings in ewes (Steen et al, 2008), beef cows (Slavik et al, 2008), dairy cows (Ortman and Pehrson, 1997), and pigs (Ortman and Pehrson, 1998;Svoboda et al, 2008). However, in the last instance, findings are more equivocal because the source of Se does not consistently alter Se concentra.tion in serum of gilts (Mahan and Kim, 1996;Mahan, 2000;Yoon and McMillan, 2006).…”

Section: Long-term Effects On Se-related Metabolitessupporting

confidence: 85%

Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts1

Fortier

Audet

Giguère

et al. 2012

Journal of Animal Science

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This project aimed to determine the effect of Se as inorganic Na-selenite (MSe) or organic Se-yeast (OSe) on antioxidant status, hormonal profile, reproductive performance, and embryo development in first-parity gilts. Forty-nine gilts were allocated to 1 of the 3 dietary treatments starting at first pubertal estrus and lasting up to 30 d after AI: control [CONT: basal diet (Se = 0.2 mg/kg) without added Se; n = 16], MSe (CONT + 0.3 mg/kg of MSe; n = 16), and OSe (CONT + 0.3 mg/kg of OSe; n = 17). Blood was collected from all gilts on the day after each onset of estrus and on d 30 after AI. Blood was also collected daily from d -4 to d +4 of the third onset of estrus (d 0) in 8 CONT, 9 MSe, and 8 OSe cannulated gilts. Gilts had received, after d 14 and 15 of their third estrus, a hormonal challenge to induce super-ovulation. At slaughter, embryos and corpora lutea (CL) were weighed and measured. Blood Se was less (P < 0.01) in CONT than in Se gilts and greater in OSe than in MSe (P < 0.01) from the first estrus until d 30 of gestation. At the same time, blood Se-dependent glutathione peroxidase (GSH-Px) decreased for CONT gilts, whereas it increased for both Se groups. The increase was greater in MSe than in OSe gilts (treatment × time, P = 0.02). Plasma 3,3',5-triiodothyronine and thyroxine concentrations for MSe tended to be less than for OSe gilts (P < 0.06). In cannulated gilts, plasma FSH tended to change among treatments (treatment × time, P = 0.06), and plasma estradiol-17β (E(2)) was less (P = 0.01) for MSe than for OSe. There was no treatment effect on mean litter size or embryonic antioxidant status. The Se content of individual embryos was greater for Se-treated than for CONT gilts (P = 0.03), and Se content of individual embryos and total litter was greater for OSe than for MSe gilts (P < 0.01). The length, weight, and protein content of embryos were greater in OSe than in MSe gilts (P < 0.05). There was no treatment effect on weight, length, Se content, and ferric reducing antioxidant power of CL, but GSH-Px in CL was greater for Se than for CONT gilts (P = 0.02). In summary, the Se status response of gilts to dietary Se was affected by both the quantity and the source of Se dietary supplements. Moreover, the uterine transfer of Se to embryos was improved with OSe as compared with MSe, and this was concomitant with an enhanced development of embryos.

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Section: Long-term Effects On Se-related Metabolitessupporting

confidence: 85%

Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts1

Fortier

Audet

Giguère

et al. 2012

Journal of Animal Science

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“…Therefore, we conclude that Se-yeast is more bioavailable than inorganic Se. Similar findings have been reported for WB-Se concentrations after administering organic vs. inorganic Se sources in studies of other sheep (Tiwary et al, 2006;Qin et al, 2007;Steen et al, 2008), cattle (Awadeh et al, 1998;Ortman and Pehrson, 1999), humans (Butler et al, 1991), and broiler chickens . There are several reasons why inorganic Se is less bioavailable than organic Se in ewes: 1) inorganic Se may be partially reduced to elemental Se in the rumen.…”

Section: Effect Of Dietary Se Source Orally Drenched At 4-9 Mg Of Sesupporting

confidence: 83%

“…Several studies have examiued how dietary Se alters blood Se couceutratious in ewes usiug various chemical sources and Se dosages (Davis et al, 2006;Steen et al, 2008;Taylor et al, 2009). Less is known how different chemical forms of Se at comparative dosages alter blood Se concentrations aud whether production stage may modify blood Se concentrations.…”

Section: Introductionmentioning

confidence: 99%

Organic and inorganic selenium: I. Oral bioavailability in ewes1

Hall

Saun

Bobe

et al. 2012

Journal of Animal Science

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Although the essentiality of dietary Se for sheep has been known for decades, the chemical source and Se dosage for optimal health remain unclear. In the United States, the Food and Drug Administration (FDA) regulates Se supplementation, regardless of the source of Se, at 0.3 mg of Se/kg of diet (as fed), which is equivalent to 0.7 mg of Se/d or 4.9 mg of Se/wk per sheep. The objectives of this study were to evaluate the effects of Se source (inorganic vs. organic) and supplementation rate (FDA vs. supranutritional rates of 14.7 and 24.5 mg of Se/wk) on whole-blood (WB) and serum-Se concentrations. Mature ewes (n = 240) were randomly assigned to 8 treatment groups (n = 30 each) based on Se supplementation rate (4.9, 14.7, and 24.5 mg of Se•wk(-1)•sheep(-1)) and source [Na-selenite, Na-selenate (4.9 mg/wk only), and organic Se-yeast] with a no-Se control group (0 mg of Se/wk). Treatment groups were balanced for healthy and footrot-affected ewes. For 1 yr, ewes were individually dosed once weekly with 0, 4.9, 14.7, or 24.5 mg of Se, quantities equivalent to their summed daily supplementation rates. Serum- and WB-Se concentrations were measured every 3 mo in all ewes; additionally, WB-Se concentrations were measured once monthly in one-half of the ewes receiving 0 or 4.9 mg of Se/wk. Ewes receiving no Se showed a 78.8 and 58.8% decrease (P < 0.001) in WB- (250 to 53 ng/mL) and serum- (97 to 40 ng/mL) Se concentrations, respectively, over the duration of the study. Whole-blood Se decreased primarily during pregnancy (-57%; 258 to 111 ng/mL) and again during peak lactation (-44%; 109 to 61 ng/mL; P < 0.001). At 4.9 mg of Se/wk, Se-yeast (364 ng/mL, final Se concentration) was more effective than Na-selenite (269 ng/mL) at increasing WB-Se concentrations (P < 0.001). Supranutritional Se-yeast dosages increased WB-Se concentrations in a dose-dependent manner (563 ng/mL, 14.7 mg of Se/wk; 748 ng/mL, 24.5 mg of Se/wk; P < 0.001), whereas WB-Se concentrations were not different for the Na-selenite groups (350 ng/mL, 14.7 mg of Se/wk; 363 ng/mL, 24.5 mg of Se/wk) or the 4.9 mg of Se/wk Se-yeast group (364 ng/mL). In summary, the dose range whereby Se supplementation increased blood Se concentrations was more limited for inorganic Na-selenite than for organic Se-yeast. The smallest rate (FDA-recommended quantity) of organic Se supplementation was equally effective as supranutritional rates of Na-selenite supplementation in increasing WB-Se concentrations, demonstrating the greater oral bioavailability of organic Se.

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“…In foods of animal origin, supplementation with organic compared with inorganic selenium results in meat of higher selenium concentration. For example, when a comparison is made between the effect of selenium yeast and sodium selenite supplements, skeletal muscle from lambs contained 0.12 and 0.08 lg selenium/g fresh weight, respectively (26), and beef contained 0.41 and 0.30 mg/kg dry weight, respectively (27).…”

Section: Selenium Speciationmentioning

confidence: 99%

Selenium bioavailability: current knowledge and future research requirements

Fairweather‐Tait¹,

Collings²,

Hurst³

2010

The American Journal of Clinical Nutrition

373

243

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Information on selenium bioavailability is required to derive dietary recommendations and to evaluate and improve the quality of food products. The need for robust data is particularly important in light of recent suggestions of potential health benefits associated with different intakes of selenium. The issue is not straightforward, however, because of large variations in the selenium content of foods (determined by a combination of geologic/environmental factors and selenium supplementation of fertilizers and animal feedstuffs) and the chemical forms of the element, which are absorbed and metabolized differently. Although most dietary selenium is absorbed efficiently, the retention of organic forms is higher than that of inorganic forms. There are also complications in the assessment and quantification of selenium species within foodstuffs. Often, extraction is only partial, and the process can alter the form or forms present in the food. Efforts to improve, standardize, and make more widely available techniques for species quantification are required. Similarly, reliable and sensitive functional biomarkers of selenium status are required, together with improvements in current biomarker methods. This requirement is particularly important for the assessment of bioavailability, because some functional biomarkers respond differently to the various selenium species. The effect of genotype adds a potential further dimension to the process of deriving bioavailability estimates and underlines the need for further research to facilitate the process of deriving dietary recommendations in the future.Am J Clin Nutr 2010;91(suppl):1484S-91S.

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Organic selenium supplementation increased selenium concentrations in ewe and newborn lamb blood and in slaughter lamb meat compared to inorganic selenium supplementation

Cited by 25 publications

References 20 publications

Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts1

Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts1

Organic and inorganic selenium: I. Oral bioavailability in ewes1

Selenium bioavailability: current knowledge and future research requirements

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