Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(ϵ-caprolactone)–poly(ethylene glycol) block copolymer based nanocarriers for protein delivery

Payyappilly, Sanal Sebastian; Panja, Subhash Chandra; Mandal, Purnendu; Dhara, Santanu; Chattopadhyay, Santanu

doi:10.1016/j.colsurfb.2015.07.075

Cited by 33 publications

(14 citation statements)

References 39 publications

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“…Morphology of polymeric micelles imposes a significant impact on drug loading and release kinetics that depends upon a number of factors such as the total molar mass of polymer, the ratio of hydrophilic to hydrophobic segment and micelles preparation methodology . AFM images of empty micelles show that micelles are spherical in shape [Figure (a–c)].…”

Section: Resultsmentioning

confidence: 99%

Enhanced therapeutic efficacy of clotrimazole by delivery through poly(ethylene oxide)‐block‐poly(ε‐caprolactone) copolymer‐based micelles

Kareem

Bhayo

Imran

et al. 2019

J of Applied Polymer Sci

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Amphiphilic block copolymers have been the subject of great scientific interests due to their applications in various fields including nano drug delivery. Three amphiphilic block copolymers based on poly(ε-caprolactone) as a hydrophobic segment and methoxy poly(ethylene oxide) ( as a hydrophilic part were synthesized by the ring-opening polymerization of ε-caprolactone using MeO-PEO 5K as macroinitiator by varying initial feed ratios. The synthesized polymers were further explored for their drug delivery potential using clotrimazole as model hydrophobic drug. Drug-loaded micelles were characterized for shape, size, drug encapsulation efficiency, in vitro release, and thermal stability using atomic force microscope, zetasizer, UV-visible spectrophotometry, FTIR, differential scanning calorimetry, and thermogravimetric analysis. Clotrimazole loaded in micelles were also investigated for its antifungal activity through an in vitro assay and scanning electron microscopy. The antifungal activity of drug increased significantly by delivering through polymeric micelles. Current study provides insight into different factors that can be maneuvered to achieve a variety of desired properties of micelles for improved therapeutic efficacy of drugs like clotrimazole.

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Section: Resultsmentioning

confidence: 99%

Enhanced therapeutic efficacy of clotrimazole by delivery through poly(ethylene oxide)‐block‐poly(ε‐caprolactone) copolymer‐based micelles

Kareem

Bhayo

Imran

et al. 2019

J of Applied Polymer Sci

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“…The glass transition temperature ( T g ) of − 60 °C and low melting point (59–64 °C) of PCL allows for the easy fabrication of delivery systems at reasonably low temperatures [10]. Furthermore, PCL has an excellent blend compatibility with other polymers which facilitates tailoring of desired properties like degradation kinetics, hydrophilicity and mucoadhesion [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions

Ajiboye

Trivedi

Mitchell

2017

Drug Deliv. and Transl. Res.

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Polycaprolactone (PCL) nanoparticles were produced via supercritical fluid extraction of emulsions (SFEE) using supercritical carbon dioxide (scCO). The efficiency of the scCO extraction was investigated and compared to that of solvent extraction at atmospheric pressure. The effects of process parameters including polymer concentration (0.6-10% w/w in acetone), surfactant concentration (0.07 and 0.14% w/w) and polymer-to-surfactant weight ratio (1:1-16:1 w/w) on the particle size and surface morphology were also investigated. Spherical PCL nanoparticles with mean particle sizes between 190 and 350 nm were obtained depending on the polymer concentration, which was the most important factor where increase in the particle size was directly related to total polymer content in the formulation. Nanoparticles produced were analysed using dynamic light scattering and scanning electron microscopy. The results indicated that SFEE can be applied for the preparation of PCL nanoparticles without agglomeration and in a comparatively short duration of only 1 h.

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“…Micelles of synthesized amphiphilic block copolymers (ABCs) with varying amphiphilicity were prepared by co‐solvent evaporation method. PCL block length may have significant effect on the size and shape of the micelles, their drug‐loading efficiency, and release kinetics . Similarly, micelles loaded with CC were also prepared using all three block copolymers.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Anti‐Bacterial Activity of Non‐Antibacterial Drug Candesartan Cilexetil by Delivery through Polymeric Micelles

et al. 2020

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Candesartan Cilexetil (CC) is a prodrug of candesartan and an angiotensin II receptor antagonist. It is used as a drug for different diseases like myocardial infarction, hypertension, and heart failure. The applicability of CC is impeded due to its poor water solubility, low permeability, and low bioavailability. This study is targeted to improve the efficacy and bioavailability of CC by its delivery through MeO‐PEO5K‐PCL micelles. The effect of length of hydrophobic block (PCL) on size of the micelles, drug encapsulation efficiency, and drug release behavior is evaluated. MeO‐PEO5K‐PCL based micelles were prepared by solvent evaporation method. The size of PMs was determined by dynamic light scattering, morphology by atomic force microscopy, and critical micelles concentration by fluorescence method. Encapsulation efficiency and drug release behaviors of MeO‐PEO5K‐PCL based PMs were evaluated by UV‐visible spectroscopy and dispersion method, respectively. The size of micelles increased and drug release rate decreased with increase in the length of PCL block. Maximum encapsulation efficiency of 96.42 % for CC is achieved with ABCs having equal PEO and PCL block lengths. A comparison of antibacterial activity of CC in pure form and encapsulated in PMs against MRSA is conducted. The MIC50 for CC loaded PMs has decreased to more than half in comparison to pure drug. AFM based morphological analysis also confirmed the decrease in MIC50 by delivery through PMs.

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Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(ϵ-caprolactone)–poly(ethylene glycol) block copolymer based nanocarriers for protein delivery

Cited by 33 publications

References 39 publications

Enhanced therapeutic efficacy of clotrimazole by delivery through poly(ethylene oxide)‐block‐poly(ε‐caprolactone) copolymer‐based micelles

Enhanced therapeutic efficacy of clotrimazole by delivery through poly(ethylene oxide)‐block‐poly(ε‐caprolactone) copolymer‐based micelles

Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions

Enhanced Anti‐Bacterial Activity of Non‐Antibacterial Drug Candesartan Cilexetil by Delivery through Polymeric Micelles

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