Organic Synthesis in Dedicated Continuous Flow Systems

Quid Pro Flow

“…Reviews − and text books − offer invaluable help, especially in fields where extensive examples of the benefits are available: e.g., organic synthesis, the pharmaceutical industry, − and, more recently, nanoparticle synthesis . Despite this, there are still barriers in terms of skills and knowledge gaps, disciplinary differences, and access to technology that prevent widespread use of flow in chemistry lab settings, particularly in fields where it is not an established technique.…”

Process intensification of dendritic fibrous nanospheres of silica (DFNS) via continuous flow: a scalable and sustainable alternative to the conventional batch synthesis

“…Continuous flow reactors are emerging as promising alternatives for traditional batch reactors. [32][33][34][35][36] Extensive literature is present to support the performance of both homogeneous 37 and heterogeneous reactions 38 through flow. The important advantages of continuous flow methods when compared to batch/hydrothermal synthesis; include (a) large surface area to volume ratio which allows efficient heat transfer, thereby affording easy adaptation of exothermic reactions 39 (b) mixing small amounts of reagents per time making the process safer, 40 (c) better control over reaction kinetics and product selectivity because of precise control of variables such as temperature, pressure, residence time, and stoichiometry, 41,42 (d) easy availability of enhanced scaleup technology after lab-based flow optimizations without the need for extensive re-designing with scale-increase, 43 and much more.…”