Organic Synthetic Methods Using Copper Oxygen Chemistry

Aerobic Copper-Catalyzed Organic Reactions

“…A number of elegant reviews on the subject of catalytic copper oxidation chemistry have appeared. Most recently, reviews provide selected coverage of copper catalysts or a discussion of their use in the aerobic functionalization of C–H bonds . Other recent reviews cover copper and other metal catalysts with a range of oxidants, including oxygen, but several reaction types are not covered .…”

Copper-Catalyzed Transformation of Hydrazones into Halogenated Azabutadienes, Versatile Building Blocks for Organic Synthesis

“…However, the reaction of hydrazone 1a with CCl 4 in the presence of catalytic amounts of CuCl followed an unanticipated path. Thus, instead of the expected trichloromethylated hydrazone 2a′ , the azadiene product 2a was isolated in 67% yield!…”

Copper Chloride Catalysis: Do μ4-Oxido Copper Clusters Play a Significant Role?

“…CuCl 2 ·2H 2 O and CuCl are simple copper salts that are widely used as catalysts for oxidative coupling as well as oxygenation reactions in organic syntheses. , Consequently, a large number of oxygenation reactions using CuCl 2 ·2H 2 O as a catalyst have been reported over the past couple decades. − Although they have been employed as catalytic reagents for a long time, little is known about the detailed reaction mechanisms. The electron transfer between the catalyst and the substrates is a key step in understanding the reactivity of this system; however, most attempts fail to explain why simple copper salts such as CuCl 2 ·2H 2 O are an efficient catalyst in multi-electron-transfer reactions.…”