Organic versus mixed specialist older adult inpatient mental health units for people with dementia

Gondhalekar, Mohan Rajendra; Bakkar, Azza; Chaplin, Robert; Parker, Eleanor; Löw, Robert

doi:10.7748/nop.2021.e1353

Cited by 1 publication

(3 citation statements)

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“… 3 , 4 Therefore, it is a public health priority to identify people at very early stages of cognitive impairment and consequently to prevent or postpone neurodegenerative diseases. 5 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 Therefore, it is a public health priority to identify people at very early stages of cognitive impairment and consequently to prevent or postpone neurodegenerative diseases. 5 In recent years, a growing body of research has shown that individuals with no evident objective cognitive impairment but who demonstrate concerns about everyday memory, known as subjective memory complaints (SMCs), are at high risk of faster cognitive decline and developing incident dementia. [6][7][8] SMCs have been suggested as an early sign of cognitive impairment.…”

Section: Introductionmentioning

confidence: 99%

“…While it is a devastating disease for our society, Alzheimer dementia has a long prodromal phase, providing a critical time window for potential interventions to successfully postpone or prevent the disease’s onset . Therefore, it is a public health priority to identify people at very early stages of cognitive impairment and consequently to prevent or postpone neurodegenerative diseases …”

Section: Introductionmentioning

confidence: 99%

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Association of Subjective Memory Complaints With White Matter Hyperintensities and Cognitive Decline Among Older Adults in Chicago, Illinois

et al. 2022

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Importance Subjective memory complaints (SMCs) are associated with a faster cognitive decline; whether this association is also associated with structural brain alterations, such as white matter hyperintensity (WMH) volumes, requires investigation. Objective To evaluate the association of SMCs with WMH volumes and cognitive decline and investigate the role of WMH volumes in the association between SMCs and cognitive decline. Design, Setting, and Participants The Chicago Health and Aging Project, a population-based cohort study, enrolled adults aged 65 years or older. Data collection occurred in 3-year cycles from 1993 until 2012. Our study comprised 975 participants with magnetic resonance imaging assessments, of which 900 participants had data on SMCs and covariates, and 713 participants provided 2 or more cognitive assessments during the follow-up. Statistical analyses were conducted from May to October 2021. Exposures SMCs were obtained from self-reported questionnaire data during clinical evaluations, and the cycle, when reported, constituted the baseline of our study. Based on the frequency and severity of concerns, we categorized participants into 3 groups, (1) no concerns, (2) moderate concerns, and (3) very worried. Main Outcomes and Measures Volumetric magnetic resonance imaging measures of WMH volume and neuropsychological testing assessments of global cognition. Linear regression analysis was used to investigate the association between SMCs and WMH volumes in a multivariable model adjusted for age, sex, race and ethnicity, education, APOE4 status, and total intracranial volume. The association of SMCs with cognitive decline was investigated using linear mixed-effects models for age, sex, race and ethnicity, education, APOE4 status, follow-up time, and each variable in interaction with time to estimate the annual longitudinal change in cognitive function. Results Of the 900 participants with data on SMCs, covariates, and WMH volumes, 553 (61.4%) were women, 539 (59.9%) were African American, and the mean (SD) age was 79.5 (6.2) years. SMCs were associated with a larger WMH volume and faster cognitive decline. Compared with participants with no concerns, participants who were very worried had higher WMH volumes (β = 0.833; 95% CI, 0.203-1.463) and 174% faster cognitive decline (β = −0.049; 95% CI, −0.076 to −0.022). The association between SMCs and cognitive decline remained statistically significant among individuals with large WMH volumes (ie, within the fourth quartile). Within the fourth quartile of WMH volumes, participants who were very worried had 428% faster cognitive decline (β = −0.077; 95% CI, −0.144 to −0.011) compared with participants with no concerns. Conclusions and Relevance This cohort study suggests that SMCs, frequently reported by older individu...

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“… 3 , 4 Therefore, it is a public health priority to identify people at very early stages of cognitive impairment and consequently to prevent or postpone neurodegenerative diseases. 5 …”

Section: Introductionmentioning

confidence: 99%