Organically Modified Silica Nanoparticles Interaction with Macrophage Cells: Assessment of Cell Viability on the Basis of Physicochemical Properties

Kumar, Dhiraj; Mutreja, Isha; Keshvan, Prashant C.; Bhat, Madhusudan; Mitra, Susmita

doi:10.1002/jps.24614

Cited by 13 publications

(7 citation statements)

References 52 publications

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“…Nonetheless, presence of S—O at 850 cm −1 , Si—O—Si at 1100 cm −1 , C—H at 1450 cm −1 (bending mode) and 2900 cm −1 (stretching mode), N—H at 3200 cm −1 as well as Si—OH at 3436 cm −1 wavelengths were detected in mNHA (APTES). These peaks correspond with the FTIR spectrum of pure APTES and other ceramics treated with APTES , indicating the surface modification of NHA through addition of APTES.…”

Section: Resultssupporting

confidence: 87%

Surface modification of nanohydroxyapatite and its loading effect on polylactic acid properties for load bearing implants

et al. 2017

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Blends of polylactic acid (PLA) and nanohydroxyapatite (NHA) were prepared through melt‐mixing by varying the composition of NHA from 1 to 5 wt%. The tensile properties of the PLA‐1 wt% NHA nanocomposite exhibited higher values than neat PLA. Beyond 1 wt% NHA, a drop in tensile properties of the PLA–NHA nanocomposites was observed due to agglomeration and poor interfacial adhesion between NHA and PLA. Therefore, NHA was surface modified (mNHA) using three different surface modifiers namely, 3‐aminopropyl triethoxysilane (APTES), sodium n‐dodecyl sulfate (SDS) and polyethylenimine (PEI). The surface treatment of NHA was studied through Fourier transform infrared spectroscopy (FTIR) and energy dispersive X‐ray (EDX). Results revealed that the tensile properties increased in order of PLA‐5 wt% mNHA (APTES) followed by PLA‐5 wt% mNHA (SDS), whereas PEI modified NHA resulted in lower tensile properties. Further, increasing mNHA loading to 30 wt%, decreased the tensile strength due to agglomeration of mNHA. POLYM. COMPOS., 39:2880–2888, 2018. © 2016 Society of Plastics Engineers

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Section: Resultssupporting

confidence: 87%

Surface modification of nanohydroxyapatite and its loading effect on polylactic acid properties for load bearing implants

et al. 2017

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“…In recent works, surface modifications of biointerfaces (silica nanoparticles, nanotubes, nanotextured surfaces) are reported to influence cell viabilities for non-adherent and adherent cells [ 46 , 47 , 48 , 49 ]. Osteogenic activity on amine-rich substrates like polydopaminated-coated Ti implants and on mercapto-functionalized surfaces, has been demonstrated to interact directly with cell proteins controlling cell adhesion and proliferation [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells

et al. 2016

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In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and pore volume have attracted considerable attention for their application in drug delivery and biomedicine. Here we propose biosilica from diatoms as an alternative source of mesoporous materials in the field of multifunctional supports for cell growth: the biosilica surfaces were chemically modified by traditional silanization methods resulting in diatom silica microparticles functionalized with 3-mercaptopropyl-trimethoxysilane (MPTMS) and 3-aminopropyl-triethoxysilane (APTES). Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses revealed that the –SH or –NH2 were successfully grafted onto the biosilica surface. The relationship among the type of functional groups and the cell viability was established as well as the interaction of the cells with the nanoporosity of frustules. These results show that diatom microparticles are promising natural biomaterials suitable for cell growth, and that the surfaces, owing to the mercapto groups, exhibit good biocompatibility.

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“…Considering the pronounced physical and chemical stability of ORMOSILs, but also their low cost, ease of preparation (and application) and excellent health and environmental profile, these findings open the route to the widespread utilization of SilverSil coatings in life‐saving applications such as the ceramic pot filter, as well as in consumer products and across domestic, hospital, school, industrial and commercial environments.…”

Section: Composition Of the Different Silversil Materialsmentioning

confidence: 99%

SilverSil: A New Class of Antibacterial Materials of Broad Scope

et al. 2020

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Consisting of organically modified silica (ORMOSIL) physically doped with Ag nanoparticles, the SilverSil new class of antibacterial materials of broad scope reported herein shows remarkably high and stable activity against representative Gram‐positive and Gram‐negative bacteria. The low cost, ease of application and excellent health and environmental profile of SilverSil hybrid glassy coatings open the route to their widespread utilization across domestic, hospital, school, industrial and commercial environments and in consumer products.

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Organically Modified Silica Nanoparticles Interaction with Macrophage Cells: Assessment of Cell Viability on the Basis of Physicochemical Properties

Cited by 13 publications

References 52 publications

Surface modification of nanohydroxyapatite and its loading effect on polylactic acid properties for load bearing implants

Surface modification of nanohydroxyapatite and its loading effect on polylactic acid properties for load bearing implants

Biosilica from Living Diatoms: Investigations on Biocompatibility of Bare and Chemically Modified Thalassiosira weissflogii Silica Shells

SilverSil: A New Class of Antibacterial Materials of Broad Scope

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