Organisation and maturation of the human thalamus as revealed by CD15

Forutan, Farhad; Mai, J.K.; Ashwell, Ken W.S.; Lensing‐Höhn, Sabine; Nöhr, Donatus; Voss, Timo-Daniel; Böhl, Jürgen; Andressen, Christian

doi:10.1002/cne.1296

Cited by 19 publications

(13 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The objective of the present investigation was to extend previous morphological data about the expression of the CD15 carbohydrate epitope on radial glial cells in the central nervous system of several vertebrate species including humans [4,[6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A CD15-Immunoreactive Subpopulation of Radial Glial Cells in the Developing Human Lateral Ganglionic Eminence

et al. 2003

View full text Add to dashboard Cite

There is evidence that precursor cells for the different derivatives of the ganglionic eminences arise from topographically different areas of the proliferative neuroepithelium, indicating a molecular specification for this histologically homogeneous region. We describe a regionally differentiated expression pattern within the lateral ganglionic eminence during human fetal development of a subpopulation of radial glial cells stained for CD15. These cells were first observed around 12–13 weeks of fertilization in the ventricular layer of the lateral ganglionic eminence at the corticostriatal sulcus. In the following weeks increasing numbers of cells and their positively stained processes concentrate along the lateral perimeter of the striatum, with processes continuing towards the pial surface defining the border between the olfactory tubercle medially and the piriform cortex laterally. The number of immunoreactive cells and processes increases until 24 weeks. At that time, these cells are found throughout the lateral ganglionic eminence, defining a border against the unstained medial ganglionic eminence. Concomitant with the rise in the number of fibres until 24 weeks of fertilization, there is also an increase in immunoreactivity in the dorsal striatum. According to the accepted role of radial glial cells as a guidance structure for migrating postmitotic neurones, these CD15-immunoreactive fibres may enable the registration between localized proliferation areas within the lateral ganglionic eminence and related differentiation areas, thereby helping to characterize the fundamental subdivisions of the brain.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In human development, CD15-ir glia cells are associated with particular differentiating fields of e.g. cochlear [9] as well as thalamic nuclei [10].…”

Section: Introductionmentioning

confidence: 99%

A CD15-Immunoreactive Subpopulation of Radial Glial Cells in the Developing Human Lateral Ganglionic Eminence

et al. 2003

View full text Add to dashboard Cite

show abstract

“…The gestational periods varied from 18-22 weeks of development with an average 18±2 weeks. The embryonic age was determined by measuring the head diameter and crown-rump length based on the data published by Forutan et al [12] and calculated according to the time from the last menstrual period (LMP) under the assumption that fertilization occurs 14 d after the LMP. No abnormal data were found in the obstetrical examination of the conceived women and the B-supersonics examination of the fetus before the operation.…”

Section: Methodsmentioning

confidence: 99%

Differential response of human fetal smooth muscle cells from arterial duct to retinoid acid

Jiang

et al. 2008

Acta Pharmacologica Sinica

View full text Add to dashboard Cite

Aim: The aim of the present study was to understand the role of retinoic acid (RA) in the development of isolated patent ductus arteriosus and the features of arterial duct-derived vascular smooth muscle cells (VSMC). Methods: The VSMC were isolated, and the biological characteristics and the response to RA were investigated in the arterial duct, aorta, and pulmonary artery VSMC from 6 human embryonic samples. Western blotting, immunostaining, and cell-based ELISA were employed to analyze the proliferation regulation of VSMC. Results: The VSMC from the arterial duct expressed proliferating cell nuclear antigen (PCNA) at a significantly lower rate than those from the aorta and pulmonary artery, but expressed a higher level of Bax and Bcl-2. The expression level of PCNA or Bcl-2 was associated with the embryonic age. The effects of RA on the VSMC from the arterial duct were quite different from those from the aorta and pulmonary artery. In arterial duct VSMC, RA stimulated PCNA expression, but such stimulation could be suppressed by CD2366, an antagonist of nuclear retinoid receptor activation. In aorta or pulmonary artery VSMC, the expression response of PCNA to RA was insignificant. The ratio of Bax/Bcl-2 decreased in arterial duct VSMC after RA treatment due to the significant inhibition of Bax expression. Conclusion: The VSMC from the arterial duct possessed distinct biological behaviors. RA might be important in the development of ductus arteriosus VSMC.

show abstract

“…The CD15 (3[␣1-3]-fucosyl-N-acetyl-lactosamine) epitope is a glycoconjugate that has been detected on a variety of cells in the immune system (Kerr and Stocks, 1992) and the central nervous system (Mai et al, 1999;Forutan et al, 2001). In the retina, CD15 immunoreactivity has been detected in several cell types (Andressen and Mai, 1997).…”

Section: Indexing Terms: Cd15; Inner Plexiform Layer; Amacrine Cells;mentioning

confidence: 99%

CD15 immunoreactive amacrine cells in the mouse retina

Jakobs

Ben

2003

J of Comparative Neurology

View full text Add to dashboard Cite

The mouse retina has become an important model in vision research, mainly because of the wide availability of transgenic animals. In order to study cell function and connectivity in the inner retina, antibodies that differentially stain one cell type, or a small number of cell types, are helpful as markers. Here we characterize the CD15 (3[alpha1-3]-fucosyl-N-acetyl-lactosamine)-positive cells in the mouse retina using immunofluorescence confocal microscopy and reverse-transcription polymerase chain reaction. CD15 immunoreactivity was observed in two distinct types of amacrine cells and, faintly, in some cone bipolar cells. Type I CD15+ amacrine cells are GABAergic wide-field cells that stratify in lamina 3 and 4/5 of the inner plexiform layer. Type II CD15+ amacrine cells are also GABAergic and costratify with the dopaminergic tyrosine hydroxylase-positive cells in lamina 1 of the inner plexiform layer. The densities of types I and II CD15+ amacrine cells in mid-periphery were 258 cells/mm(2) and 274 cells/mm(2). Double labeling with several other markers for amacrine cell types showed that neither type belongs to another previously identified subpopulation of amacrine cells. Single-cell RT-PCR showed that CD15+ amacrine cells coexpress several AMPA receptors - GluR1, GluR2, and GluR4 being the most common combination.

show abstract

Organisation and maturation of the human thalamus as revealed by CD15

Cited by 19 publications

References 66 publications

A CD15-Immunoreactive Subpopulation of Radial Glial Cells in the Developing Human Lateral Ganglionic Eminence

A CD15-Immunoreactive Subpopulation of Radial Glial Cells in the Developing Human Lateral Ganglionic Eminence

Differential response of human fetal smooth muscle cells from arterial duct to retinoid acid

CD15 immunoreactive amacrine cells in the mouse retina

Contact Info

Product

Resources

About