Organization and Regulation of Mitochondrial Oxidative Phosphorylation

Rigoulet, Michel; Mourier, Arnaud; Devin, Anne

doi:10.1002/9783527621095.ch2

Cited by 2 publications

(2 citation statements)

References 157 publications

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“…Protons gather and create an electrochemical gradient throughout the inner mitochondrial membrane. This osmotic potential is used to power ATP synthesis when protons re-enter the mitochondrial matrix through ATP synthase [13].…”

Section: Structural Assembly Of F 1 F 0 Atp Synthasementioning

confidence: 99%

ATP Synthase: Structure, Function and Inhibition

Neupane

Bhuju

Thapa

et al. 2019

Biomolecular Concepts

144

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Oxidative phosphorylation is carried out by five complexes, which are the sites for electron transport and ATP synthesis. Among those, Complex V (also known as the F1F0 ATP Synthase or ATPase) is responsible for the generation of ATP through phosphorylation of ADP by using electrochemical energy generated by proton gradient across the inner membrane of mitochondria. A multi subunit structure that works like a pump functions along the proton gradient across the membranes which not only results in ATP synthesis and breakdown, but also facilitates electron transport. Since ATP is the major energy currency in all living cells, its synthesis and function have widely been studied over the last few decades uncovering several aspects of ATP synthase. This review intends to summarize the structure, function and inhibition of the ATP synthase.

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Section: Structural Assembly Of F 1 F 0 Atp Synthasementioning

confidence: 99%

ATP Synthase: Structure, Function and Inhibition

Neupane

Bhuju

Thapa

et al. 2019

Biomolecular Concepts

144

View full text Add to dashboard Cite

show abstract

“…This was the expected outcome from a method accounting for coefficients assessing the impact of both systemic and individual steps in the biochemical network. MCA also revealed that the pattern of control changes more quantitatively (control strength) rather than qualitatively (steps involved) following changes in physiological conditions [11–14]. Since its introduction, MCA has been extensively applied to study properties of isolated mitochondria from liver [15–17], muscle [18,19] and other sources [20], although few studies have been carried out using intact cells [11,12] or tissue [8].…”

Section: Control and Regulation Of Oxidative Phosphorylation And Atp mentioning

confidence: 99%

Control and Regulation of Integrated Mitochondrial Function in Metabolic and Transport Networks

Cortassa

O’Rourke

Winslow³

et al. 2009

IJMS

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Abstract:The pattern of flux and concentration control coefficients in an integrated mitochondrial energetics model is examined by applying a generalized matrix method of control analysis to calculate control coefficients, as well as response coefficients The computational model of Cortassa et al. encompasses oxidative phosphorylation, the TCA cycle, and Ca 2+ dynamics. Control of ATP synthesis, TCA cycle, and ANT fluxes were found to be distributed among various mitochondrial processes. Control is shared by processes associated with ATP/ADP production and transport, as well as by Ca 2+ dynamics. The calculation also analyzed the control of the concentrations of key regulatory ions and metabolites (Ca 2+ , NADH, ADP). The approach we have used demonstrates how properties of integrated systems may be understood through applications of computational modeling and control analysis.

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Organization and Regulation of Mitochondrial Oxidative Phosphorylation

Cited by 2 publications

References 157 publications

ATP Synthase: Structure, Function and Inhibition

ATP Synthase: Structure, Function and Inhibition

Control and Regulation of Integrated Mitochondrial Function in Metabolic and Transport Networks

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