Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat

McDonald, Alexander J.

doi:10.1016/0306-4522(91)90247-l

Cited by 426 publications

(312 citation statements)

References 33 publications

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“…The positive temporal relationship between activity in mPFC and BLA neurons observed in the present study is also in general agreement with the results of a recent study (Likhtik et al, 2005) and may occur as a result of the direct reciprocal projections between these regions (McDonald, 1991(McDonald, , 1998. However, the BLA and mPFC also receive common sources of afferent input from thalamus (Krettek and Price, 1977;Ray and Price, 1992), hippocampus (Ishikawa and Nakamura, in press) and monoamine cell bodies (Fallon et al, 1978;Oades and Halliday, 1987;Room et al, 1981).…”

Section: Discussionsupporting

confidence: 93%

“…These areas share reciprocal connections (McDonald, 1991(McDonald, , 1998 and evidence from combined stimulation and in vivo electro-physiology studies indicates that these connections are functionally relevant. Electrical stimulation of BLA inhibits spontaneous activity in mPFC projection neurons, possibly by activating local GABA interneurons (Pérez-Jaranay and Vives, 1991).…”

Section: Introductionmentioning

confidence: 99%

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Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

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The medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) coordinate various stress responses. Although the effects of stressors on mPFC and BLA activity have been previously examined, it remains unclear to what extent stressors affect functional interactions between these regions. In vivo electrophysiology in the anesthetized rat was used to examine mPFC and BLA activity simultaneously in response to FG-7142, a benzodiazepine receptor partial inverse agonist that mimics various stress responses, in an attempt to model the effects of stressors on corticolimbic functional connectivity. Extracellular unit and local field potential (LFP) recordings, using multielectrode arrays positioned in mPFC and BLA, were conducted under basal conditions and in response to systemic FG-7142 administration. This drug increased mPFC and BLA unit firing at the lowest dose tested, whereas higher doses of FG-7142 decreased various burst firing parameters in both regions. Moreover, LFP power was attenuated at lower (<1 Hz) and potentiated at higher frequencies in mPFC (1-12 Hz) and BLA (4-8 Hz). Interestingly, FG-7142 diminished synchronized unit firing, both within and between mPFC and BLA. Finally, FG-7142 decreased LFP synchronization between these regions. In a separate group of animals, pretreatment with the selective benzodiazepine receptor antagonist flumazenil blocked the changes in burst firing, LFP power and synchronized activity induced by FG-7142, confirming direct benzodiazepine receptor-mediated effects. These results indicate that FG-7142 disrupts corticolimbic network interactions via benzodiazepine receptor partial inverse agonism. Perturbation of mPFC-BLA functional connectivity induced by FG-7142 may provide a useful model of corticolimbic dysfunction induced by stressors.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Stevenson

Halliday

Marsden

et al. 2007

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“…Circuitry involved in the development of reinforced behaviors is a central part of this network (see Figure 1). Principal components of the mesocorticolimbic reward circuit include amygdala, hippocampus, nucleus accumbens (ventral striatum), and ventral diencephalon(including basal forebrain, ventral tegmentum, and hypothalamus), and cortical areas with modulating and oversight functions, such as dorsolateral-prefrontal, orbitofrontal, temporal pole, subcallosal, and cingulate cortices, parahippocampal gyri, and the insula (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). We hypothesized that morphometric abnormalities would present in alcoholic subjects in these subcortical gray-matter limbic and paralimbic regions, which mediate primary reward functions, together with associated cortical centers, which are important for executive functioning, emotional judgment and responses, decision making, and oversight (2,16).…”

Section: Introductionmentioning

confidence: 99%

Decreased Volume of the Brain Reward System in Alcoholism

Makris

Oscar‐Berman

Jaffin

et al. 2008

Biological Psychiatry

345

327

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Background-Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" or "reward-network"). We examined whether rewardnetwork brain volumes are reduced in alcoholics, and how volumes of subcomponents within this system are correlated with memory and drinking-history.

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“…The NAc has two major subregions-the shell and the core-defined by histochemical, electrophysiological, connectivity and cellular criteria (O'Donnell and Grace 1993;Jongen-Relo et al 1994). This structure receives glutamatergic projections from the ventral hippocampus (vHC) (DeFrance et al 1985), which is involved in generating context, task attention and emotion (Fanselow and Dong 2010); the basolateral nucleus of the amygdala (BLA) (Groenewegen et al 1980;McDonald 1991), which mediates emotional behaviour; and the prefrontal cortex (Fuller et al 1987), which modulates activity throughout the limbic system to enable behavioural flexibility. The paraventricular nucleus of the thalamus (PVT) a part of midline and intralaminar thalamus, which is implicated in behavioural responses to psychostimulant drugs Young and Deutch 1998) and the regulation of autonomic and visceral functions (Bhatnagar and Dallman 1999), particularly in response to stress (Bhatnagar et al 2000), also projects to the shell region of the NAc.…”

Section: Introductionmentioning

confidence: 99%

Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow

et al. 2011

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The nucleus accumbens (NAc) is positioned to integrate signals originating from limbic and cortical areas and to modulate reward-related motor output of various goal-directed behaviours. The major target of the NAc GABAergic output neurons is the ventral pallidum (VP). VP is part of the reward circuit and controls the ascending mesolimbic dopamine system, as well as the motor output structures and the brainstem. The excitatory inputs governing this system converge in the NAc from the prefrontal cortex (PFC), ventral hippocampus (vHC), midline and intralaminar thalamus (TH) and basolateral nucleus of the amygdala (BLA). It is unclear which if any of these afferents innervate the medium spiny neurons of the NAc, that project to the VP. To identify the source of glutamatergic afferents that innervate neurons projecting to the VP, a duallabelling method was used: Phaseolus vulgaris leucoagglutinin for anterograde and EGFP-encoded adenovirus for retrograde tract-tracing. Within the NAc, anterogradely labelled BLA terminals formed asymmetric synapses on dendritic spines that belonged to medium spiny neurons retrogradely labelled from the VP. TH terminals also formed synapses on dendritic spines of NAc neurons projecting to the VP. However, dendrites and dendritic spines retrogradely labelled from VP received no direct synaptic contacts from afferents originating from mPFC and vHC in the present material, despite the large number of fibres labelled by the anterograde tracer injections. These findings represent the first experimental evidence for a selective glutamatergic innervation of NAc neurons projecting to the VP. The glutamatergic inputs of different origin (i.e. mPFC, vHC, BLA, TH) to the NAc might thus convey different types of reward-related information during goal-directed behaviour, and thereby contribute to the complex regulation of nucleus accumbens functions.

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Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat

Cited by 426 publications

References 33 publications

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Systemic administration of the benzodiazepine receptor partial inverse agonist FG‐7142 disrupts corticolimbic network interactions

Decreased Volume of the Brain Reward System in Alcoholism

Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow

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