“…Long-range projections can be cell type-specific ( Hu and Agmon, 2016 ; Williams and Holtmaat, 2019 ). Both vS1 and PO target Pyr excitatory and inhibitory neurons, with layer-specific complementary activation of PV+ and somatostatin (SOM+) inhibitory neurons in M1 ( Okoro et al, 2022 ). The organizational principles of cortical neurons studied to date in visual ( Alonso and Martinez, 1998 ; Dantzker and Callaway, 2000 ; Alonso et al, 2001 ; Gonchar and Burkhalter, 2003 ; Song et al, 2005 ; Yoshimura and Callaway, 2005 ; Yoshimura et al, 2005 ; Brown and Hestrin, 2009 ; Bock et al, 2011 ; Kätzel et al, 2011 ; Ko et al, 2011 , 2013 , 2014 ; Glickfeld et al, 2013 ; Cossell et al, 2015 ; Wertz et al, 2015 ; W.A.…”