2022
DOI: 10.1523/jneurosci.0950-22.2022
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Organization of Cortical and Thalamic Input to Inhibitory Neurons in Mouse Motor Cortex

Abstract: Intracortical inhibition in motor cortex (M1) regulates movement and motor learning. If cortical and thalamic inputs target different inhibitory cell types in different layers, then these afferents may play different roles in regulating M1 output. Using mice of both sexes, we quantified input to two main classes of M1 interneurons, parvalbumin+ (PV+) cells and somatostatin+ (SOM+) cells, using monosynaptic rabies tracing. We then compared anatomic and functional connectivity based on synaptic strength from sen… Show more

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Cited by 9 publications
(19 citation statements)
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“…Our prior data, using subcellular Channelrhodopsin-assisted circuit mapping (sCRACM), had shown that both vS1 input and PO input similarly excited vM1 L5A Pyr neurons most strongly and L2/3 Pyr neurons with ∼70–90% of this strength ( Mao et al, 2011 ; Hooks et al, 2013 ). But for PV+ neurons, this pattern shifted and vS1 excited L2/3 PV+ neurons more strongly than L5A, while PO excited L5A PV+ neurons more strongly than L2/3 ( Okoro et al, 2022 ). Based on this difference in connection strength, EPSCs amplitudes in PV+ cells divided by the amplitudes of EPSCs in Pyr cells should result in larger ratios from vS1 stimulation compared with PO stimulation in L2/3 in our paired recordings.…”
Section: Resultsmentioning
confidence: 91%
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“…Our prior data, using subcellular Channelrhodopsin-assisted circuit mapping (sCRACM), had shown that both vS1 input and PO input similarly excited vM1 L5A Pyr neurons most strongly and L2/3 Pyr neurons with ∼70–90% of this strength ( Mao et al, 2011 ; Hooks et al, 2013 ). But for PV+ neurons, this pattern shifted and vS1 excited L2/3 PV+ neurons more strongly than L5A, while PO excited L5A PV+ neurons more strongly than L2/3 ( Okoro et al, 2022 ). Based on this difference in connection strength, EPSCs amplitudes in PV+ cells divided by the amplitudes of EPSCs in Pyr cells should result in larger ratios from vS1 stimulation compared with PO stimulation in L2/3 in our paired recordings.…”
Section: Resultsmentioning
confidence: 91%
“…Animal protocols were approved by the Institutional Animal Care and Use Committee at University of Pittsburgh. Experimental procedures were similar to previous studies ( Okoro et al, 2022 ). Mice of either sex were used at postnatal day (P) ages P28–P123 (average, P46; median, P43; mode, P37; N = 123 mice, n = 133 slices, 1–10 cells per slice).…”
Section: Methodsmentioning
confidence: 94%
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“…Neurons of the primary, secondary, and accessory motor cortices receive multiple inputs from different areas of the brain. In particular, significant mediation and modulation are made by the anterior motor-related thalamic regions, including the ventral anterior thalamic and the ventrolateral thalamic nuclei, and the posterior sensory-related thalamic areas, including the posterior thalamic nuclear group [ 28 , 29 ].…”
Section: Discussionmentioning
confidence: 99%