Organization of inhibitory feed-forward synapses from the dorsal to the ventral cochlear nucleus in the cat: a quantitative analysis of endings by vesicle morphology

Presynaptic Ryanodine Receptors Are Required for Normal Quantal Size at theCaenorhabditis elegansNeuromuscular Junction

“…The sections were traced in random sequence by an individual without the knowledge of the genotypes. The tracings were scanned and saved as tagged image file format files, which were subsequently analyzed with the Optimas program version 6.5 (Media Cybernetics) to determine the area of synaptic vesicles (Munirathinam et al, 2004). The diameter of a synaptic vesicle was calculated from its area assuming that the vesicle was a perfect sphere.…”

Review: Cytological characteristics of commissural and tuberculo-ventral neurons in the rat dorsal cochlear nucleus

“…It is possible that the content of neurotransmitters can be different in the subtypes of FP, R, and P boutons, as those found in a quantitative analysis of terminal boutons in the cochlear nucleus (Munirathinam et al, 2004).…”

“…R-boutons contain essentially round vesicles (large, >450 nm, or small, <450 nm) and generally form asymmetric synapses (where the presynaptic membrane thickening is thinner than the post-synaptic). A recent, more quantitative analysis of synaptic boutons in the cochlear nucleus has found seven different ending types (Munirathinam et al, 2004).…”

A biophysical modelling platform of the cochlear nucleus and other auditory circuits: From channels to networks

“…In particular, the intrinsic excitability (Bal and Oertel, 2001; Ferragamo et al, 1998; Golding et al, 1999; Hirsch and Oertel, 1988a; Hirsch and Oertel, 1988b; Kuo et al, 2012; Manis, 1990; Manis et al, 1994; Oertel, 1983; Oertel et al, 1990; Rodrigues and Oertel, 2006; Street and Manis, 2007; Zhang and Oertel, 1993a; Zhang and Oertel, 1993b), the ion channels that underlie the intrinsic excitability of the cells (Bal and Oertel, 2001; Cao and Oertel, 2011; Cao et al, 2007; Harasztosi et al, 1999; Kanold and Manis, 1999; Kim and Trussell, 2006; Manis and Marx, 1991; Manis et al, 2003; Rothman and Manis, 2003a; Rothman and Manis, 2003c; Rusznák et al, 1996; Rusznák et al, 1997), the kinetics of synaptic conductances (Gardner et al, 1999; Gardner et al, 2001; Harty and Manis, 1998; Kopp-Scheinpflug et al, 2002; Nerlich et al, 2014; Raman and Trussell, 1992; Raman et al, 1994; Xie and Manis, 2013; Xie and Manis, 2014) and the temporal dynamics of synaptic transmitter release (Kuo et al, 2012; Mancilla and Manis, 2009; Roberts and Trussell, 2010; Wang and Manis, 2008; Wang et al, 2010; Xie and Manis, 2013; Xie and Manis, 2017b; Yang and Xu-Friedman, 2008; Yang and Xu-Friedman, 2009) have been quantitatively described for several of the principal cell types. Connectivity amongst the cells within the territories of the cochlear nuclear complex is known qualitatively (Campagnola and Manis, 2014; Mancilla and Manis, 2009; Muniak and Ryugo, 2014; Munirathinam et al, 2004; Oertel et al, 1990; Ostapoff et al, 1999; Roberts and Trussell, 2010; Roberts et al, 2008; Wickesberg and Oertel, 1988; Wickesberg et al, 1991; Yaeger and Trussell, 2015; Yaeger and Trussell, 2016), and new methods are on the horizon to provide better quantitative measures of connections between identified neuronal classes (Deerinck et al, 2015; Denk and Horstmann, 2004; Holcomb et al, 2013;…”