Organization of prefrontal outflow toward frontal motor‐related areas in macaque monkeys

Takada, Masahiko; Nambu, Atsushi; Hatanaka, Nobuhiko; Tachibana, Yoshihisa; Miyachi, Shigehiro; Taira, Masato; Inase, Masahiko

doi:10.1111/j.0953-816x.2004.03425.x

Cited by 67 publications

(60 citation statements)

References 59 publications

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“…In contrast, dorsal area 46 exhibited much weaker labeling. This indicates that ventral area 46, but not dorsal area 46, is preferentially involved in the control of forelimb movements, albeit both areas are directly interconnected with the rostral motor-related areas (Arikuni et al, 1980;Barbas and Pandya, 1987;Lu et al, 1994;Takada et al, 2004). Consistent with our findings, previous physiological studies have reported that ventral area 46 neurons were specifically activated during the performance of delayed response tasks, in which monkeys responded manually (di Pellegrino and Wise, 1991;Hoshi et al, 1998;Rainer et al, 1998).…”

Section: Discussionsupporting

confidence: 91%

“…Likewise, many of the labeled neurons in the prefrontal cortex can be considered third-order neurons, because conspicuous labeling of striatal neurons and Purkinje cells appeared coincidently. Our quantitative analysis has revealed that the number of labeled neurons was increased exponentially, first in the caudal motor-related areas, then in the rostral motor-related areas, and finally in the prefrontal areas (Bates and Goldman-Rakic, 1993;Luppino et al, 2003;Takada et al, 2004). In addition, the rapid increase in labeled neuron number could be ascribed to transneuronal labeling through intrinsic and/or bypath circuits.…”

Section: Discussionmentioning

confidence: 81%

“…At this stage, neurons in the rostral motor-related areas were only sparsely labeled, although part of the areas (i.e., the CMAr) has relatively weak projections to the MI (Dum and Strick, 1991;Takada et al, 2004). On the third day, substantial neuronal labeling extended over the rostral motorrelated areas, including the PMdr, PMvr, pre-SMA, and CMAr.…”

Section: Discussionmentioning

confidence: 89%

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Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus

Miyachi¹,

Lu²,

Inoue³

et al. 2005

J. Neurosci.

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The organization of multisynaptic projections from the prefrontal cortex to the primary motor cortex (MI) was examined in macaque monkeys by retrograde transneuronal transport of rabies virus. In the first series of experiments, the virus was injected into the MI forelimb region, and the time-dependent distribution patterns of transsynaptic labeling were analyzed in the frontal lobe with various survivals (2-4 d). Two days after the viral injection, neuronal labeling emerged in the caudal aspects of the nonprimary motor-related areas that are known to project to the MI directly. At the same time, the motor thalamus contained labeled neurons. On the third day, cortical labeling extended into the rostral motor-related areas and, also, prearcuate area 8. Moreover, a number of labeled neurons were located in the internal pallidum and the cerebellar nuclei. At the 4 d postinjection period, neuronal labeling occurred widely in prefrontal areas as well as in the putamen and the cerebellar cortex. In the second series of experiments, the viral injection was made into the MI hindlimb region, and the distribution pattern of prefrontal labeling on the fourth day was compared with that in the forelimb-injection case. The labeled neurons in each prefrontal area were much fewer in the hindlimb-injection case than in the forelimb-injection case. Whereas ventral area 46 was most densely labeled from the forelimb region, only sparse labeling from the hindlimb region was observed in this prefrontal area. The present results suggest the importance of ventral area 46 in the cognitive control of forelimb movements.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 89%

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Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus

Miyachi¹,

Lu²,

Inoue³

et al. 2005

J. Neurosci.

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“…It has been argued that the caudal CMA can be subdivided into dorsal and ventral (CAMv) components. In the monkey, all of the cingulate motor areas are interconnected with dorsal and ventral divisions of lateral premotor cortex (Barbas and Pandya, 1987;Luppino et al, 1998Luppino et al, , 2003Hatanaka et al, 2003;Takada et al, 2004). There is little evidence for connections between the cingulate gyrus, ventral and posterior to the CMAs, and the lateral premotor cortex.…”

Section: Definition Of Target Masksmentioning

confidence: 99%

Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization

Beckmann

Johansen‐Berg²,

Rushworth³

2009

J. Neurosci.

738

600

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Whole-brain neuroimaging studies have demonstrated regional variations in function within human cingulate cortex. At the same time, regional variations in cingulate anatomical connections have been found in animal models. It has, however, been difficult to estimate the relationship between connectivity and function throughout the whole cingulate cortex within the human brain. In this study, magnetic resonance diffusion tractography was used to investigate cingulate probabilistic connectivity in the human brain with two approaches. First, an algorithm was used to search for regional variations in the probabilistic connectivity profiles of all cingulate cortex voxels with the whole of the rest of the brain. Nine subregions with distinctive connectivity profiles were identified. It was possible to characterize several distinct areas in the dorsal cingulate sulcal region. Several distinct regions were also found in subgenual and perigenual cortex. Second, the probabilities of connection between cingulate cortex and 11 predefined target regions of interest were calculated. Cingulate voxels with a high probability of connection with the different targets formed separate clusters within cingulate cortex. Distinct connectivity fingerprints characterized the likelihood of connections between the extracingulate target regions and the nine cingulate subregions. Last, a meta-analysis of 171 functional studies reporting cingulate activation was performed. Seven different cognitive conditions were selected and peak activation coordinates were plotted to create maps of functional localization within the cingulate cortex. Regional functional specialization was found to be related to regional differences in probabilistic anatomical connectivity.

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“…cortical plasticity | frontal executive function T he primate dorsomedial prefrontal cortex (PFC), and particularly its posterior region (pmPFC), is intimately connected with higher-order cortical motor areas in the frontal lobe, including the presupplementary motor area (pre-SMA), the rostral cingulate motor area, and the dorsal premotor area (1)(2)(3)(4). This relationship with cortical motor areas resembles connections from the dorsolateral PFC (dlPFC), suggesting that both areas influence downstream motor areas during the selection, preparation, and execution of actions (5)(6)(7)(8).…”

mentioning

confidence: 99%

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

Matsuzaka

Akiyama

Tanji

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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The functional roles of the primate posterior medial prefrontal cortex have remained largely unknown. Here, we show that this region participates in the regulation of actions in the presence of multiple response tactics. Monkeys performed a forelimb task in which a visual cue required prompt decision of reaching to a left or a right target. The location of the cue was either ipsilateral (concordant) or contralateral (discordant) to the target. As a result of extensive training, the reaction times for the concordant and discordant trials were indistinguishable, indicating that the monkeys developed tactics to overcome the cue-response conflict. Prefrontal neurons exhibited prominent activity when the concordant and discordant trials were randomly presented, requiring rapid selection of a response tactic (reach toward or away from the cue). The following findings indicate that these neurons are involved in the selection of tactics, rather than the selection of action or monitoring of response conflict: (i) The response period activity of neurons in this region disappeared when the monkeys performed the task under the behavioral condition that required a single tactic alone, whereas the action varied across trials. (ii) The neuronal activity was found in the dorsomedial prefrontal cortex but not in the anterior cingulate cortex that has been implicated for the response conflict monitoring. These results suggest that the medial prefrontal cortex participates in the selection of a response tactic that determines an appropriate action. Furthermore, the observation of dynamic, task-dependent neuronal activity necessitates reconsideration of the conventional concept of cortical motor representation.cortical plasticity | frontal executive function T he primate dorsomedial prefrontal cortex (PFC), and particularly its posterior region (pmPFC), is intimately connected with higher-order cortical motor areas in the frontal lobe, including the presupplementary motor area (pre-SMA), the rostral cingulate motor area, and the dorsal premotor area (1-4). This relationship with cortical motor areas resembles connections from the dorsolateral PFC (dlPFC), suggesting that both areas influence downstream motor areas during the selection, preparation, and execution of actions (5-8). Despite numerous studies demonstrating the involvement of the dlPFC in various aspects of behavioral control (9-12), however, little is known about the role of the pmPFC in the performance of motor behaviors.A few studies have attempted to explore this area. For example, Petrides proposed that the dorsomedial PFC plays important roles in monitoring multiple events and self-ordering actions (13), although his later study suggested that the dlPFC is also involved in this process (14). Bon and Lucchetti reported that electrical stimulation in area 8b evoked ear or eye movements, and neurons in this region showed activity modulation related to these types of movements (15, 16). Human brain-imaging studies identified active areas including the mPFC that were re...

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Organization of prefrontal outflow toward frontal motor‐related areas in macaque monkeys

Cited by 67 publications

References 59 publications

Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus

Organization of Multisynaptic Inputs from Prefrontal Cortex to Primary Motor Cortex as Revealed by Retrograde Transneuronal Transport of Rabies Virus

Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization

Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics

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