Organization of the coeruleo-vestibular pathway in rats, rabbits, and monkeys

Schuerger, R.J.; Balaban, Carey D.

doi:10.1016/s0165-0173(99)00015-6

Cited by 74 publications

(50 citation statements)

References 129 publications

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“…The variability of symptoms and clinical findings both during and between attacks suggests that migraine interacts with the vestibular system at various levels 19 . The vestibular nuclei receive noradrenergic inputs from the locus ceruleus and serotoninergic inputs from the dorsal raphe nucleus 20,21 . Therefore, activation of these nuclei during migraine attacks may give rise to vestibular symptoms.…”

Section: Pathophysiologymentioning

confidence: 99%

Vestibular migraine: diagnosis challenges and need for targeted treatment

Barbosa

Villa

2016

Arq. Neuro-Psiquiatr.

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Approximately 1% of the general population suffers from vestibular migraine. Despite the recently published diagnostic criteria, it is still underdiagnosed condition. The exact neural mechanisms of vestibular migraine are still unclear, but the variability of symptoms and clinical findings both during and between attacks suggests an important interaction between trigeminal and vestibular systems. Vestibular migraine often begins several years after typical migraine and has a variable clinical presentation. In vestibular migraine patients, the neurological and neurotological examination is mostly normal and the diagnosis will be based in the patient clinical history. Treatment trials that specialize on vestibular migraine are scarce and therapeutic recommendations are based on migraine guidelines. Controlled studies on the efficacy of pharmacologic interventions in the treatment of vestibular migraine should be performed.

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Section: Pathophysiologymentioning

confidence: 99%

Vestibular migraine: diagnosis challenges and need for targeted treatment

Barbosa

Villa

2016

Arq. Neuro-Psiquiatr.

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“…For example, vestibular and tactile stimulation typically induces visual alertness in human newborns (Becker et al 1993, Korner & Grobstein 1966, Korner & Thoman 1970. Structures in the ascending noradrenergic pathway are involved in the processing of vestibular input (Nishiike et al 1997, Pompeiano et al 1991, Schuerger & Balaban 1999, and so it seems possible that stimulation involved in common caregiving activities (picking up or rocking the infant) may produce changes in norepinephrine in any number of higher-order brain areas. Furthermore, it is also the case that newborns' and 1-month-old infants' visual responses to stimuli of different levels of complexity, motion, or novelty are strongly affected by manipulations of arousal, such as feeding or swaddling (Gardner & Karmel 1981, 1984Gardner et al 1992;Gardner & Turkewitz 1982;Geva et al 1999), or by prior stimulation in modalities other than vision (Gardner et al 1986).…”

Section: The Alert State In Young Infantsmentioning

confidence: 99%

The Development of Visual Attention in Infancy

Colombo

2001

Annu. Rev. Psychol.

556

548

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Over the past decade, the study of attention in infancy has seen dramatic progress. This review delineates four attentional functions (alertness, spatial orienting, attention to object features, and endogenous attention) that are relevant to infancy and uses these functions as a framework for summarizing the developmental course of attention in infancy. Rudimentary forms of various attentional functions are present at birth, but each of the functions exhibits different and apparently dissociable periods of postnatal change during the first years of life. The role of attention in development should therefore be considered in the context of interaction among different systems at different levels of maturity during the first years of life.

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“…. Immunoreactivity for tyrosine hydroxylase (TH) was visualized using previously established procedures (Schuerger and Balaban, 1999). The mouse monoclonal anti-TH antibody (MAB318; Chemicon; used at a concentration of 1:1000), which was prepared against a 59-61 kDa protein on the outside of the regulatory N-terminus of TH purified from PC12 cells, does not cross react with other monoamine synthesis enzymes on Western blot.…”

Section: Tissue Processing For Sert and Bdamentioning

confidence: 99%

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

Halberstadt

Balaban

2008

Journal of Chemical Neuroanatomy

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The dorsal raphe nucleus (DRN) contains both serotonergic and non-serotonergic projection neurons. Retrograde tracing studies have demonstrated that components of the basal forebrain and extended amygdala are targeted heavily by input from nonserotonergic DRN neurons. The object of this investigation was to examine the terminal distribution of nonserotonergic DRN projections in the basal forebrain and extended amygdala, using a technique that allows selective anterograde tracing of nonserotonergic DRN projections. To trace nonserotonergic DRN projections, animals were pretreated with nomifensine, desipramine and the serotonergic neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), 7 days prior to placing an iontophoretic injection of biotinylated dextran amine (BDA) into the DRN. In animals treated with 5,7-DHT, numerous nonserotonergic BDA-labeled fibers ascended to the basal forebrain in the medial forebrain bundle system. Some of these labeled fibers crossed through the lateral hypothalamus, bed nucleus of the stria terminalis, and substantial innominata. These fibers entered the amygdala through the ansa peduncularis and ramified within the central and basolateral amygdaloid nuclei. Other fibers entered the diagonal band of Broca and formed a dense plexus of labeled fibers in the dorsal half of the intermediate portion of the lateral septal nucleus and the septohippocampal nucleus. These findings demonstrate that the basal forebrain and extended amygdala receive a dense projection from nonserotonergic DRN neurons. Given that the basal forebrain plays a critical role in processes such as motivation, affect, and behavioral control, these findings support the hypothesis that nonserotonergic DRN projections may exert substantial modulatory control over emotional and motivational functions. Keywords amygdala; bed nucleus; 5,7-dihydroxytryptamine; septal nuclei; biotinylated dextran amine; tyrosine hydroxylase It is well known that the dorsal raphe nucleus contains more than half of all the serotonergic neurons in the brain (Leger and Wiklund, 1982) and is a source of projections that terminate extensively throughout the central nervous system (Vertes, 1991;Sim and Joseph, 1993;Vertes and Kocsis, 1994;Morin and Meyer-Bernstein, 1999 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. within dorsomedial (DRNdm), ventromedial (DRNvm), and lateral (DRNl) cell groups . It has been proposed that the activity of serotonergic DRN neurons plays an important role in the coordination of sensory processing and motor output with the sleep-wake-arousal cycle (Jacobs and Azmitia, 1992; Forn...

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Organization of the coeruleo-vestibular pathway in rats, rabbits, and monkeys

Cited by 74 publications

References 129 publications

Vestibular migraine: diagnosis challenges and need for targeted treatment

Vestibular migraine: diagnosis challenges and need for targeted treatment

The Development of Visual Attention in Infancy

Selective anterograde tracing of nonserotonergic projections from dorsal raphe nucleus to the basal forebrain and extended amygdala

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