2021
DOI: 10.3390/biomedicines9080998
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Organization of the Cytoskeleton in Ectopic Foci of the Endometrium with Rare Localization

Abstract: (1) Background: Endometriosis is a common pathology of the female reproductive system, often accompanied by pain and decreased fertility. However, its pathogenesis has not been sufficiently studied regarding the role of the cytoskeleton. In this study, we describe two clinical cases involving rare localization of extragenital endometriosis (umbilicus) and compare them with genital endometriosis of different localization (ovaries and uterus), as well as eutopic endometrium obtained with separate diagnostic cure… Show more

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Cited by 5 publications
(2 citation statements)
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“…An increase in PKM can lead to its accumulation in the intercellular space and induce cell migration through p-Tyr42 RhoA-mediated superoxide generation [45], leading to the formation of extragenital lesions. In addition, the RhoAdependent pathway may also be involved in an increase in the expression of a number of cytoskeletal proteins associated with an increase in migration potential, which we observed depending on the distance from the site of eutopic localization [46]. The results we obtained in this study are fully consistent with data on a decrease in OXPHOS in human peritoneal mesothelial and endometrial cells of nonhuman primates with endometriosis [26,27] and a transition to aerobic glycolysis [24,39,47].…”
Section: Discussionsupporting
confidence: 91%
“…An increase in PKM can lead to its accumulation in the intercellular space and induce cell migration through p-Tyr42 RhoA-mediated superoxide generation [45], leading to the formation of extragenital lesions. In addition, the RhoAdependent pathway may also be involved in an increase in the expression of a number of cytoskeletal proteins associated with an increase in migration potential, which we observed depending on the distance from the site of eutopic localization [46]. The results we obtained in this study are fully consistent with data on a decrease in OXPHOS in human peritoneal mesothelial and endometrial cells of nonhuman primates with endometriosis [26,27] and a transition to aerobic glycolysis [24,39,47].…”
Section: Discussionsupporting
confidence: 91%
“…This implies that as ectopic endometrial foci relocate from their typical sites, the α-actinin-1 [9] content may rise, potentially signaling the increased migratory capacity of these cells. Additionally, a favorable prognosis in endometriosis could be attributed to the decrease in tubulin content, indicating a reduced rate of cell division [146].…”
Section: Cytoskeletal Proteins: Potential Contributors In Endometriosismentioning
confidence: 99%