Organization of the efferent projections of the medial superior olivary nucleus in the cat as revealed by HRP and autoradiographic tracing methods

Henkel, Craig K.; Spangler, Kevin M.

doi:10.1002/cne.902210405

Cited by 133 publications

(65 citation statements)

References 31 publications

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“…Interestingly, three of four neurons had highly oriented dendrites, one in the central nucleus and two in the dorsal cortex. Their presence in the dorsal cortex is consistent with findings that show MSO fibers penetrating into the low-frequency part of the dorsal cortex (Henkel and Spangler, 1983;Oliver and Beckius, 1993). Thus, both subdivisions may inherit their I TD sensitivity from a common input.…”

Section: Interaural Time Differences: Heterogeneity Of Responsessupporting

confidence: 89%

Intracellular Recordings in Response to Monaural and Binaural Stimulation of Neurons in the Inferior Colliculus of the Cat

et al. 1997

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The inferior colliculus (IC) is a major auditory structure that integrates synaptic inputs from ascending, descending, and intrinsic sources. Intracellular recording in situ allows direct examination of synaptic inputs to the IC in response to acoustic stimulation. Using this technique and monaural or binaural stimulation, responses in the IC that reflect input from a lower center can be distinguished from responses that reflect synaptic integration within the IC. Our results indicate that many IC neurons receive synaptic inputs from multiple sources. Few, if any, IC neurons acted as simple relay cells. Responses often displayed complex interactions between excitatory and inhibitory sources, such that different synaptic mechanisms could underlie similar response patterns. Thus, it may be an oversimplification to classify the responses of IC neurons as simply excitatory or inhibitory, as is done in many studies. In addition, inhibition and intrinsic membrane properties appeared to play key roles in creating de novo temporal response patterns in the IC.

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Section: Interaural Time Differences: Heterogeneity Of Responsessupporting

confidence: 89%

Intracellular Recordings in Response to Monaural and Binaural Stimulation of Neurons in the Inferior Colliculus of the Cat

et al. 1997

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“…All neurons of the mammalian ventral cochlear nucleus, some of which phase-lock to acoustic stimuli (Lavine, 197 1;Goldberg and Brownell, 1973;Rose et al, 1974), have been reported to contain CaBP (Jande et al, 198 1;Garcia-Segura et al, 1984) in the rat. The medial superior olive, which also contains phase-locking neurons (Moushegian et al, 1967;Goldberg and Brown, 1969) and is thought to be the mammalian homolog of the avian NL (Ramon y Cajal, 1908), projects to a region in the ventrolateral portion of the ICC (Van Noort, 1969;Elverland, 1978;Henkel and Spangler, 1983). CaBP-immunoreactive fibers, which have been reported in the mammalian inferior colliculus (Garcia-Segura et al, 1984), may be restricted to the ventrolateral sector.…”

Section: Discussionmentioning

confidence: 99%

Calcium binding protein-like immunoreactivity labels the terminal field of nucleus laminaris of the barn owl

Takahashi¹,

Carr²,

Brecha³

et al. 1987

J. Neurosci.

101

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Nucleus laminaris (NL) is the site at which the timing of sounds arriving in the 2 ears is compared in the auditory system of the barn owl. Earlier studies have reported vitamin D-dependent calcium binding protein (CaBP)-like immunoreactivity in the somata of NL. We report here that CaBP-like immunoreactivity stains the terminal field of NL. The specific CaBP immunoreactivity is localized to a dense plexus of fibers that have bouton-like swellings, usually around unstained somata. This type of immunoreactivity is found in a restricted portion of the central nucleus of the inferior colliculus (ICc), in the anterior division of the ventral lateral lemniscal complex (VLVA), and in the superior olivary nucleus (SO), all of which have been shown by anterograde transport of 3H-proline to be innervated by NL. The immunoreactivity is absent from the posterior division of ventral lateral lemniscal complex and from the region that surrounds the portion of ICc innervated by NL. A restricted lesion in NL results in a localized deficit in immunoreactivity in those regions of ICc and VLVA that are known to be innervated by the lesioned area of NL. In adjacent sections processed by the Fink-Heimer method, degenerating axons are present in the region of the deficit in immunoreactivity.

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“…If so, we would expect a tendency for neighboring neurons to have the same type of frequency response map because there is considerable anatomical evidence that projections from different brain stem nuclei are at least partially segregated in ICC (Henkel and Spangler 1983;Oliver et al 1997;Shneiderman and Henkel 1987). Contrary to this prediction, analysis of the distribution of response maps among neighboring unit pairs revealed no significant deviation from a random distribution across recording sites, suggesting a complex organization and mixing of these different functional response patterns within local regions.…”

Section: Width Of Frequency Tuning and Response Area Typesmentioning

confidence: 95%

“…Incoming axons run parallel to these sheets. The input from lower nuclei tend to form distinct projection bands that partly interleave and partly overlap with axon bands from other nuclei (Henkel and Spangler 1983;Oliver et al 1997;Shneiderman and Henkel 1987).…”

Section: Introductionmentioning

confidence: 99%

Response Properties of Neighboring Neurons in the Auditory Midbrain for Pure-Tone Stimulation: A Tetrode Study

Seshagiri

Delgutte²

2007

Journal of Neurophysiology

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Seshagiri CV, Delgutte B. Response properties of neighboring neurons in the auditory midbrain for pure-tone stimulation: a tetrode study. J Neurophysiol 98: 2058J Neurophysiol 98: -2073J Neurophysiol 98: , 2007. First published August 1, 2007; doi:10.1152/jn.01317.2006. The complex anatomical structure of the central nucleus of the inferior colliculus (ICC), the principal auditory nucleus in the midbrain, may provide the basis for functional organization of auditory information. To investigate this organization, we used tetrodes to record from neighboring neurons in the ICC of anesthetized cats and studied the similarity and difference among the responses of these neurons to pure-tone stimuli using widely used physiological characterizations. Consistent with the tonotopic arrangement of neurons in the ICC and reports of a threshold map, we found a high degree of correlation in the best frequencies (BFs) of neighboring neurons, which were mostly Ͻ3 kHz in our sample, and the pure-tone thresholds among neighboring neurons. However, width of frequency tuning, shapes of the frequency response areas, and temporal discharge patterns showed little or no correlation among neighboring neurons. Because the BF and threshold are measured at levels near the threshold and the characteristic frequency (CF), neighboring neurons may receive similar primary inputs tuned to their CF; however, at higher levels, additional inputs from other frequency channels may be recruited, introducing greater variability in the responses. There was also no correlation among neighboring neurons' sensitivity to interaural time differences (ITD) measured with binaural beats. However, the characteristic phases (CPs) of neighboring neurons revealed a significant correlation. Because the CP is related to the neural mechanisms generating the ITD sensitivity, this result is consistent with segregation of inputs to the ICC from the lateral and medial superior olives.

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Organization of the efferent projections of the medial superior olivary nucleus in the cat as revealed by HRP and autoradiographic tracing methods

Cited by 133 publications

References 31 publications

Intracellular Recordings in Response to Monaural and Binaural Stimulation of Neurons in the Inferior Colliculus of the Cat

Intracellular Recordings in Response to Monaural and Binaural Stimulation of Neurons in the Inferior Colliculus of the Cat

Calcium binding protein-like immunoreactivity labels the terminal field of nucleus laminaris of the barn owl

Response Properties of Neighboring Neurons in the Auditory Midbrain for Pure-Tone Stimulation: A Tetrode Study

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