Organization of the gonadotropin-inhibitory hormone (Lpxrfa) system in the brain of zebrafish (Danio rerio)

Song, Yanlong; Wei, Peng; Luo, Junzhi; Zhang, Zhu; Hu, Wei

doi:10.1016/j.ygcen.2021.113722

Cited by 7 publications

(2 citation statements)

References 34 publications

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“…; https://doi.org/10.1101/2023.03. 29.534505 doi: bioRxiv preprint many transgenic zebrafish have been produced using the enhancer/promoter regions of various neuropeptide genes (Liu et al, 2003;Levitas-Djerbi et al, 2015;Förster et al, 2017;Koide et al, 2018;Shainer et al, 2019;Song et al, 2021). By closely examining the expression patterns of neuropeptides and neurotransmitters, we found that some of the hypothalamic nuclei described in the zebrafish reference brain atlas (Wullimann et al, 1996) contained multiple subregions with different expression patterns of neuropeptides, which we defined as subnuclei.…”

Section: Introductionmentioning

confidence: 98%

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

Hiraki-Kajiyama

Miyasaka

Ando

et al. 2023

Preprint

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Zebrafish is a useful model organism in neuroscience; however, its gene expression atlas in the adult brain is not well developed. In the present study, we examined the expression of 38 neuropeptides, and glutamatergic neuron marker gene mix (slc17a6a, slc17a6b, slc17a7a, and slc17a7b) in the adult zebrafish brain using in situ hybridization. The results are summarized as an expression atlas in 19 coronal planes of the forebrain. Furthermore, the scan data of all sections were made publicly available as a database. Based on these data, we performed detailed neuroanatomical analyses of the hypothalamus. By scrutinizing and comparing the expression patterns of neuropeptides, we found that several regions described as one nucleus in the reference zebrafish brain atlas contain two or more subregions with significantly different neuropeptide/neurotransmitter expression profiles, and we proposed them as novel subnuclei. Subsequently, the expression data obtained in this study were compared with those in mice, and a cluster analysis was performed to examine the similarities. As a result, several nuclei in zebrafish and mice were clustered in close vicinity: zebrafish ventral part of the anterior part of the parvocellular preoptic nucleus (PPav)/magnocellular preoptic nucleus (PM) and mouse paraventricular hypothalamic nucleus (Pa), zebrafish posterior part of the parvocellular preoptic nucleus (PPp) and mouse medial preoptic area (MPA), zebrafish dorsal part of the ventral zone of periventricular hypothalamus (Hvd)/anterior tuberal nucleus (ATN) and mouse ventromedial hypothalamic nucleus (VMN). The present expression atlas, database, and anatomical findings will contribute to future neuroscientific research using zebrafish.

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Section: Introductionmentioning

confidence: 98%

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

Hiraki-Kajiyama

Miyasaka

Ando

et al. 2023

Preprint

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show abstract

“…As neuropeptides tend to be expressed in specific types or small localized populations of neurons in the brain, they can also be used as markers for groups of neurons of interest and as genetic tools for visualizing and manipulating these neurons. Indeed, many transgenic zebrafish have been produced using the enhancer/promoter regions of various neuropeptide genes (Förster et al., 2017; Koide et al., 2018; Levitas‐Djerbi et al., 2015; Liu et al., 2003; Shainer et al., 2019; Yanlong Song et al., 2021). By closely examining the expression patterns of neuropeptides and neurotransmitters, we found that some of the hypothalamic nuclei described in the zebrafish reference brain atlas (Wullimann et al., 1996) contained multiple subregions with different expression patterns of neuropeptides.…”

Section: Introductionmentioning

confidence: 99%

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

Hiraki‐Kajiyama,

Miyasaka,

Ando

et al. 2024

J of Comparative Neurology

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Zebrafish is a useful model organism in neuroscience; however, its gene expression atlas in the adult brain is not well developed. In the present study, we examined the expression of 38 neuropeptides, comparing with GABAergic and glutamatergic neuron marker genes in the adult zebrafish brain by comprehensive in situ hybridization. The results are summarized as an expression atlas in 19 coronal planes of the forebrain. Furthermore, the scanned data of all brain sections were made publicly available in the Adult Zebrafish Brain Gene Expression Database (https://ssbd.riken.jp/azebex/). Based on these data, we performed detailed comparative neuroanatomical analyses of the hypothalamus and found that several regions previously described as one nucleus in the reference zebrafish brain atlas contain two or more subregions with significantly different neuropeptide/neurotransmitter expression profiles. Subsequently, we compared the expression data in zebrafish telencephalon and hypothalamus obtained in this study with those in mice, by performing a cluster analysis. As a result, several nuclei in zebrafish and mice were clustered in close vicinity. The present expression atlas, database, and anatomical findings will contribute to future neuroscience research using zebrafish.

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LPXRFa and LPXRFa-R in the female swamp eel (Monopterus albus): Molecular cloning, tissue distribution and gonadal function

Chao,

Lv,

Wang

et al. 2024

Aquaculture Reports

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Organization of the gonadotropin-inhibitory hormone (Lpxrfa) system in the brain of zebrafish (Danio rerio)

Cited by 7 publications

References 34 publications

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

An atlas and database of neuropeptide gene expression in the adult zebrafish forebrain

LPXRFa and LPXRFa-R in the female swamp eel (Monopterus albus): Molecular cloning, tissue distribution and gonadal function

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