2022
DOI: 10.1101/2022.09.13.507863
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Organization of Upstream ESCRT Machinery at the HIV-1 Budding Site

Abstract: In the late stages of the HIV-1 life cycle, membrane localization and self-assembly of the Gag polyproteins induce membrane deformation and budding. However, release of the immature virion requires direct interaction between Gag lattice and upstream ESCRT machinery at the budding site, followed by assembly of the downstream ESCRT-III factors, culminating in membrane scission. In this work, using <span>bottom-up</span> coarse-grained (CG) molecular dynamics (MD) simulations we investigated the inter… Show more

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