During the Anti-Japanese War, China's higher education faced unprecedented difficulties. A large number of well-known universities relocated to northern Guangdong to carry out education. During this period, the curriculum teaching of the relocated universities was given a special historical mission by the times, not only to continue the learning process of higher education, but also to cultivate students' awareness and ability to resist the war. However, precisely during such difficult times, the relocated universities in northern Guangdong achieved good teaching results.