Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Corsi-Cabrera, María; Ugalde, Edmundo Granda; Río-Portilla, Yolanda del; Fernández‐Guasti, Alonso

doi:10.1002/1098-2302(200011)37:3<194::aid-dev7>3.0.co;2-i

Cited by 8 publications

(7 citation statements)

References 80 publications

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“…Similar findings have been reported by studies that used prenatal and postnatal testosterone propionate (TP) treatment as an alternative to GNX, as it disrupts normal sexual differentiation and induces virilization [19–21]. Prenatal TP treatment abolished sex differences and increased the absolute power of all frequency bands, with the exception of the beta band, in both sexes [16, 17]. TP administration prenatally also masculinized the network activity of female rats, as evidenced by greater theta absolute power, reduced beta relative power, and enhanced interparietal correlation [16, 17].…”

Section: Sex Differences In Circuit Function Activity and Regulationsupporting

confidence: 65%

“…GNX male rats exhibited higher overall absolute power (raw power value recorded) than females, a sex difference that is not present in healthy rats [18]. However, when males were postnatally GNX, they exhibited more feminized EEG features, such as enhanced relative beta power, indicating that testicular steroids are essential for the masculinization of brain activity during the neonatal period [17]. Similar findings have been reported by studies that used prenatal and postnatal testosterone propionate (TP) treatment as an alternative to GNX, as it disrupts normal sexual differentiation and induces virilization [19–21].…”

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 59%

“…Prenatal TP treatment abolished sex differences and increased the absolute power of all frequency bands, with the exception of the beta band, in both sexes [16, 17]. TP administration prenatally also masculinized the network activity of female rats, as evidenced by greater theta absolute power, reduced beta relative power, and enhanced interparietal correlation [16, 17]. These results indicate that sex differences in oscillatory activity are established during this critical period of sexual differentiation, likely through the organizational effects of sex steroids.…”

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 99%

“…Attempts to delineate the mechanistic role of sex hormones in regulating the activity of neuronal circuitry have most commonly come from animal studies where these hormones can be directly manipulated. For instance, following puberty, gonadectomized (GNX) rats no longer showed right over left parietal activation or the aforementioned sex differences in interhemispheric coherence, and theta and delta relative power [17, 18]. GNX male rats exhibited higher overall absolute power (raw power value recorded) than females, a sex difference that is not present in healthy rats [18].…”

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 99%

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Hormonal regulation of circuit function: sex, systems and depression

Thériault

Perreault

2019

Biol Sex Differ

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Major depressive disorder (MDD) is a debilitating chronic illness that is two times more prevalent in women than in men. The mechanisms associated with the increased female susceptibility to depression remain poorly characterized. Aberrant neuronal oscillatory activity within the putative depression network is an emerging mechanism underlying MDD. However, innate sex differences in network activity and its contribution to depression vulnerability have not been well described. In this review, current evidence of sex differences in neuronal oscillatory activity, including the influence of sex hormones and female cycling, will first be described followed by evidence of disrupted neuronal circuit function in MDD and the effects of antidepressant treatment. Lastly, current knowledge of sex differences in MDD-associated aberrant circuit function and oscillatory activity will be highlighted, with an emphasis on the role of sex steroids and female cycling. Collectively, it is clear that there are significant gaps in the literature regarding innate and pathologically associated sex differences in network activity and that the elucidation of these differences is invaluable to our understanding of sex-specific vulnerabilities and therapies for MDD.

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Section: Sex Differences In Circuit Function Activity and Regulationsupporting

confidence: 65%

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 59%

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 99%

Section: Sex Differences In Circuit Function Activity and Regulationmentioning

confidence: 99%

See 2 more Smart Citations

Hormonal regulation of circuit function: sex, systems and depression

Thériault

Perreault

2019

Biol Sex Differ

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“…The body of evidence to suggest that hormonal factors influence spatial abilities is growing (Hampson, 1990a(Hampson, , 1990bHampson & Kimura, 1988;Silverman & Phillips, 1993;Van Goozen, Cohen-Kettenis, Gooren, Fridja, & Van de Poll, 1994,1995. Additionally, recent experimental research has indicated that hormones may also have a direct effect on EEG (Corsi-Cabrera, Ugalde, Del-Rio- Portilla, & Fernandez-Guasti, 2000). These different lines of research could all be used to explain the results of the current study.…”

Section: Overall Findingsmentioning

confidence: 99%

The effects of age and sex on mental rotation performance, verbal performance, and brain electrical activity

Roberts

Bell

2002

Developmental Psychobiology

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This study examined the effects of age and sex on mental rotation performance, verbal performance, and brain‐wave activity. Thirty‐two 8‐year‐olds (16 boys) and 32 college students (16 men) had EEG recorded at baseline and while performing four computerized tasks: a two‐dimensional (2D) gingerbread man mental rotation, a 2D alphanumeric mental rotation, of three‐dimensional (3D) basketball player mental rotation, and lexical decision making. Additionally, participants completed a paper‐ and pencil water level task and an oral verbal fluency task. On the 2D alphanumeric and 3D basketball player mental rotation tasks, men performed better than boys, but the performance of women and girls did not differ. On the water level task, men performed better than women whereas there was no difference between boys and girls. No sex differences were found on the 2D gingerbread man mental rotation, lexical decision‐making, and verbal fluency tasks. EEG analyses indicated that men exhibited left posterior temporal activation during the 2D alphanumeric task and that men and boys both exhibited greater left parietal activation than women and girls during the 2D gingerbread man task. On the 3D basketball player mental rotation task, all participants exhibited greater activation of the right parietal area than the left parietal area. These data give insight into the brain activity and cognitive development changes that occur between childhood and adulthood. © 2002 Wiley Periodicals, Inc. Dev Psychobiol 40: 391–407, 2002. Published online in Wiley InterScience (http://www.interscience.wiley.com). DOI 10.1002/dev.10039

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Prefrontal activity decline in women under a single dose of diazepam during rule-guided responses: an fMRI study

et al. 2016

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Daily life events confront us with new situations demanding responses to usual and unusual rules. Diazepam (DZ), a clinically important drug, facilitates the inhibitory activity of the GABAergic system. Prefrontal cortex, rich in DZ receptors, coordinates necessary resources to direct actions according to rules. The balance between excitatory and inhibitory activity is critical to achieve optimal function of brain systems leading to complex functions. Major sex differences in the physiological mechanisms of the GABAergic system have been reported. However, the differential influence of DZ on men and women in neural activity during behavior directed by frontal lobes remains unexplored. The ability of healthy volunteers to select responses following usual/congruent and novel/incongruent rules, and brain correlates were measured with fMRI under the administration of DZ and a placebo. 10 mg of DZ was enough to decrease the performance in a different manner between men and women. While reaction times increased in both men and women, women committed more errors selecting responses than men under DZ. Men demonstrated increased activity, while women demonstrated decreased activity in frontal regions involved in response selection of rules. These findings could have important consequences in understanding the differential influences of DZ between the sexes in complex daily life situations. More importantly, this study emphasizes the importance of understanding the differential effects on men and women of drugs widely employed by society, thereby achieves better therapeutic results and avoids side effects that the present study revealed to be different between sexes.

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Organizational and activational effects of gonadal steroid hormones on the EEG of male and female rats

Cited by 8 publications

References 80 publications

Hormonal regulation of circuit function: sex, systems and depression

Hormonal regulation of circuit function: sex, systems and depression

The effects of age and sex on mental rotation performance, verbal performance, and brain electrical activity

Prefrontal activity decline in women under a single dose of diazepam during rule-guided responses: an fMRI study

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