Organized Arrangements of “Holes” in Ionic Planes:  Crystalline Bis[tetra-dodecylammonium] hexafluorosilicate, a Group 15 Salt with Four Long <i>n</i>-Alkyl Chains and a Divalent Anion

Abdallah, David J.; Kwait, Dylan C.; Bachman, Robert E.; Weiss, Richard G.

doi:10.1021/cg010001i

Cited by 3 publications

(1 citation statement)

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“…Weiss and co-workers previously implicated related extendedchain conformations of tetra(alkyl)phosphonium salts to explain their ability to robustly form smectic thermotropic liquid crystals. 75,76 Subtle changes to the lipidoid structure and environmental conditions evidently shift the equilibrium between the L α and I II phases, from which we infer the factors governing their molecular conformations.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Protonation-Driven Aqueous Lyotropic Self-Assembly of Synthetic Six-Tail Lipidoids

et al. 2020

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We report the aqueous lyotropic mesophase behaviors of protonated amine-based “lipidoids,” a class of synthetic lipid-like molecules that mirrors essential structural features of the multitail bacterial amphiphile lipid A. Small-angle X-ray scattering (SAXS) studies demonstrate that the protonation of the tetra(amine) headgroups of six-tail lipidoids in aqueous HCl, HNO3, H2SO4, and H3PO4 solutions variably drives their self-assembly into lamellar (Lα) and inverse micellar (III) lyotropic liquid crystals (LLCs), depending on acid identity and concentration, amphiphile tail length, and temperature. Lipidoid assemblies formed in H2SO4(aq) exhibit rare inverse body-centered cubic (BCC) and inverse face-centered cubic (FCC) micellar morphologies, the latter of which unexpectedly coexists with zero mean curvature Lα phases. Complementary atomistic molecular dynamics (MD) simulations furnish detailed insights into this unusual self-assembly behavior. The unique aqueous lyotropic mesophase behaviors of ammonium lipidoids originate in their dichotomous ability to adopt both inverse conical and chain-extended molecular conformations depending on the number of counterions and their identity, which lead to coexisting supramolecular assemblies with remarkably different mean interfacial curvatures.

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Section: ■ Results and Discussionmentioning

confidence: 99%