Organizing Pneumonia With Intense 68Ga-FAPI Uptake Mimicking Lung Cancer on 68Ga-FAPI PET/CT

Tang, Wenxin; Wu, Junhao; Yang, Shun-Cheng; Wang, Qixin; Chen, Yue

doi:10.1097/rlu.0000000000003855

Cited by 24 publications

(51 citation statements)

References 12 publications

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“…In our study, mediastinal lymph nodes of two patients that were false positive on 18 F-FDG PET/CT due to anthracosis were negative on 68 Ga-FAPI PET/CT. Similar recent case reports support our findings [19,20]. Lymph node parameters less than 10 mm, low metabolic activity and small tumor volume can cause false negativity on 18 F-FDG PET/CT [18,21].…”

Section: Discussionsupporting

confidence: 92%

Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer

Can

Kepenek

Kömek

et al. 2022

Nuclear Medicine Communications

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In this study, we aimed to compare the diagnostic accuracy of 18 F−fluorodeoxyglucose ( 18 F-FDG) and Gallium-68 labeled fibroblast activator protein inhibitor ( 68 Ga-FAPI)-04 PET/CT in the tumor-node-metastasis (TNM) staging of patients with nonsmall cell lung cancer (NSCLC) and investigate whether adenocarcinoma (ADC) and squamous cell cancer (SCC) exhibit different uptake patterns on 68 Ga-FAPI-04 PET/CT. Materials and methodTwenty-nine patients with a histopathologically-confirmed diagnosis of NSCLC, who had no history of previous radiation therapy or chemotherapy and underwent 18 F-FDG PET/CT and 68 Ga-FAPI-04 PET/CT imaging between January 2021 and December 2021 were included in this retrospective study. Staging was performed using the 8th edition of the TNM staging system on both 18 F-FDG PET/CT and 68 Ga-FAPI-04 PET/CT images. Standardized uptake value (SUV) max and tumor-to-background ratios (TBR) were calculated on primary lesions and metastases. ResultsThere was no statistically significant difference in primary lesions in terms of SUV max and TBR values. However, 68 Ga-FAPI-04 PET/CT was significantly superior to 18 F-FDG PET/CT in terms of the number of lymph nodes and bone metastases revealed. The SUV max and TBR values of lymph nodes, hepatic lesions and bone lesions were significantly higher on 68 Ga-FAPI-04 PET/ CT than on 18 F-FDG PET/CT. 68 Ga-FAPI-04 PET/CT changed the disease stage of three patients (10.9%). The diagnostic accuracy of 68 Ga-FAPI-04 PET/CT was 100%, whereas the diagnostic accuracy of 18 F-FDG PET/CT was 89.6% (P = 0.250). ConclusionAlthough 68 Ga-FAPI-04 PET/CT detected more lesions and higher diagnostic accuracy than 18 F-FDG PET/CT in NSCLC, neither method was statistically superior to each other in terms of diagnostic accuracy in TNM staging.

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Section: Discussionsupporting

confidence: 92%

Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer

Can

Kepenek

Kömek

et al. 2022

Nuclear Medicine Communications

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“…Imaging of isolated liver abscess lesions in 18 F-FDG PET/CT has been reported in the past 6–8 . Increased 68 Ga-FAPI activity has been previously reported in different infectious diseases including syphilis, 9 organizing pneumonia, 10 tuberculosis, 11 and cryptococcus 12 . Our case illustrates that 68 Ga-DOTA-FAPI PET/CT can be a 1-stop search for systemic occult lesions in patients with K. pneumoniae invasion syndrome.…”

supporting

confidence: 56%

Elevated 68Ga-FAPI Activity in Klebsiella pneumoniae Invasion Syndrome

Xie,

Tang,

et al. 2023

Clin Nucl Med

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Klebsiella pneumoniae invasion syndrome is a rare disease associated with primary liver abscess and secondary extrahepatic infection. We report a case of K. pneumoniae invasion syndrome with elevated 68Ga-FAPI uptake, mimicking malignancy with multiple metastases. Our case illustrated that K. pneumoniae invasion syndrome should be considered as a possible etiology when diagnosing multiple 68Ga-FAPI–avid liver foci with metastatic lesions. Besides, PET/CT could be an integrated tool to search for systemic occult lesions in K. pneumoniae invasion syndrome.

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“…68 Ga-DOTA-FAPI-04 is a novel PET agent that has been shown to be promising for imaging tumors 5,6 . In addition, 68 Ga-DOTA-FAPI-04 in multiple inflammatory lesions including tuberculosis, 7 arthritis, 8 chronic colitis, 9 esophagitis, 10 thyroiditis, 11 organizing pneumonia, 12 immunoglobulin G4–related disease, 13 SAPHO syndrome, 14 and dermatomyositis 15 has also been reported. In our case, 68 Ga-DOTA-FAPI-04 uptake was significantly increased in radioactive iodine–induced chronic parotitis.…”

mentioning

confidence: 99%

68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis

Zhang

et al. 2022

Clin Nucl Med

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68 Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, inflammatory lesions can also show increased FAPI uptake. Herein, we reported a 52-year-old woman who underwent total thyroidectomy for thyroid papillary carcinoma 1 year ago and underwent adjuvant radioiodine therapy 1 month later. After 131 I therapy, she began to develop pain and swelling in bilateral cheeks, which developed into oral dryness. The patient was diagnosed with radioactive iodine-induced parotitis. 68 Ga-DOTA-FAPI-04 PET/CT showed the density of bilateral parotid glands increased, and the volume decreased with intense tracer uptake. 99m TcO 4 − salivary gland scintigraphy showed decreased tracer uptake in the bilateral parotid glands.

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Organizing Pneumonia With Intense 68Ga-FAPI Uptake Mimicking Lung Cancer on 68Ga-FAPI PET/CT

Cited by 24 publications

References 12 publications

Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer

Comparison of 18F-FDG PET/CT and 68Ga-FAPI-04 PET/CT in patients with non-small cell lung cancer

Elevated 68Ga-FAPI Activity in Klebsiella pneumoniae Invasion Syndrome

68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis

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