Organo-chlorine Pesticide Residues in Human Fat and Human Milk

Egan, H.; Goulding, Roy; Roburn, J.; Jo, Tatton

doi:10.1136/bmj.2.5453.66

Cited by 108 publications

(14 citation statements)

References 8 publications

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“…In 1963 and 1964 a further study, instigated by the Advisory Committee on Pesticides and Other Toxic Chemicals, was carried out jointly by the Ministry of Health and the Laboratory of the Government Chemist. This study covered selected centres in England and Wales (Egan et al, 1965). A second and larger joint study by these two bodies has now been carried out and the field has been extended to include Scotland.…”

Section: Introductionmentioning

confidence: 99%

Organochlorine Pesticide Residues in Human Fat in Great Britain

Abbott¹,

Goulding²,

Tatton³

1968

BMJ

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Acute Myocardial Infarction-Norris et al. MEDICA JOURNAL dying, heart failure on admission, as determined clinically and radiologically, being nearly as likely to result in death from arrhythmia as in death from failure. Patients suffering late arrhythmic death were, however, much more ill than the survivors, having a greatly increased incidence of shock and heart failure, and a greater incidence of transmural infarction, particularly involving the anterior part of the heart. A detailed analysis of our 70 cases of late arrhythmic death showed that, excluding a few who had clearly diagnosable reinfarction, all but four had radiological evidence of interstitial or pulmonary oederna on admission, or heart failure, hypotension, or a major arrhythmia during the first few days after admission.It is doubtful whether long-term E.C.G. monitoring of all patients at risk of late arrhythmic death is economically feasible or psychologically desirable, and it is probable that the yield in lives saved will be considerably less than by the institution of early intensive care as practised by Pantridge and his colleagues. It is also true that ventricular fibrillation complicating heart failure or shock has a poor prognosis in spite of monitoring and resuscitation (Robinson, 1965). Nevertheless, it is thought that arrhythmic death in patients who are recovering from circulatory failure is in many cases preventable with antiarrhythmic drugs, and the logical use of E.C.G. telemetry (Cerkez et at., 1965) is in this group of patients.It is now our practice, in a four-bedded coronary care unit which has opened at Green Lane Hospital since this study was completed, to readmit patients who have had heart failure or major arrhythmia during their three to seven day3 of initial monitoring from the ward to the unit if their condition deteriorates. Warning signs of impending death from ventricular fibrillation are taken to be further chest pain not quickly relieved by trinitrin, a fall in blood pressure, or irregularity in the pulse which was not present before. Nurses are instructed to feel the pulse at the wrist of all coronary patients for a full minute and to report irregularities and ectopic beats. As late arrhythmic death occurs so seldom in uncomplicated cases, it can be argued that it is unnecessary to keep these patients in hospital for more than a week, and that mobilization and rehabilitation may be correspondingly accelerated.We are grateful to the visiting physicians of Auckland, Green Lane, and Middlemore Hospitals for allowing patients under their care to be studied, and to the medical registrars for accurate recording of information. Dr. P. W. T. Brandt, radiologist to the cardiological and cardiothoracic surgical units at Green Lane Hospital, kindly reviewed all the chest x-ray films. Facilities for the transfer of data to punch cards and analysis of the results were provided by the medical statistics unit of the Auckland Hospital Board.

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Section: Introductionmentioning

confidence: 99%

Organochlorine Pesticide Residues in Human Fat in Great Britain

Abbott¹,

Goulding²,

Tatton³

1968

BMJ

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“…The study reported here was undertaken jointly by the Laboratory of the Government Chemist (Department of Trade and Industry) and the Department of Health and Social Security on behalf of the Panel for the Collection of Residues Data of the Scientific Sub-Committee of the Advisory Committee on Pesticides and Other Toxic Chemicals. In its mode of operation it was very similar to the studies carried out in 1963-4 (Egan et al, 1965) andin 1965-7 (Abbott et al, 1968), but on this occasion the field was further extended to include Northem Ireland and also parts of south-west England; samples were also received from an additional centre in Scotland.…”

Section: Introductionmentioning

confidence: 89%

Organochlorine Pesticide Residues in Human Fat in the United Kingdom 1969-71

Abbott¹,

Collins²,

Goulding³

1972

BMJ

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“…In studies in man, EGAN et al (1965) found that tissue storage levels of BHC, dieldrin, and DDT were significantly higher for persons over 40 years old than for those in the one-to 39-year age group. The correlation coeflicients for tissue storage of various pesticides with respect to age were: p,p 0.268;0.207;total BHC isomers,0.348;and dieldrin,0.323.…”

Section: B) Agementioning

confidence: 96%

Residue Reviews / Rückstands-Berichte

1967

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Organo-chlorine Pesticide Residues in Human Fat and Human Milk

Cited by 108 publications

References 8 publications

Organochlorine Pesticide Residues in Human Fat in Great Britain

Organochlorine Pesticide Residues in Human Fat in Great Britain

Organochlorine Pesticide Residues in Human Fat in the United Kingdom 1969-71

Residue Reviews / Rückstands-Berichte

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