Organocatálise Enantiosseletiva: Evolução E Aspectos Recentes

Abstract

In the last two decades, enantioselective organocatalysis has established itself as one of the three pillars of asymmetric catalysis. The rapid growth in the area is due to the rationalization of organocatalysis based on the generic modes of catalyst activation, being applied to several types of reactions, in a rather generic and predictable way and providing high enantioselectivities. This tutorial review presents the evolution of this area through a brief discussion on all generic modes of activation previously systematized in the literature: activation via enamine, iminium ion, hydrogen-bonding, counterion, SOMO, photoredox, carbene and phase-transfer, and the recent advances in the area.

Enantioselective Povarov Reactions: An Update of a Powerful Catalytic Synthetic Methodology

“…An outstanding pioneer work was the intramolecular aldol reaction catalyzed by ( S )‐proline 38 , developed independently by pharmaceutical companies Hoffman‐La Roche and Schering AG (Scheme 5). [57,58] This approach was almost ignored for three decades, but from the current century it has become one of the main methodologies in organic synthesis. A variety of carbon−carbon and carbon−heteroatom bond‐forming reactions (Diels‐Alder and its variations, 1,3‐dipolar cycloadditions, aldol condensation, Mannich and Michael reactions, among others) can be performed using organocatalytic methods [59–62] .…”