Organocatalysis in aqueous micellar medium: a new protocol for the synthesis of [1,2,4]-triazolyl-thiazolidinones

1,4‐Piperazinium Hydrogen Sulfate {[H‐pi]HSO4} a Novel Di‐Cationic Ionic Liquid: Synthesis, Characterization and Its Applications as a Catalyst in Various Organic Transformations

“…The results showed that piperazine decomposed before 130 °C, while [H‐pi]HSO 4 have higher thermal stability and decomposed at 315 °C. This increase could be caused by hydrogen bonding and nearby the positive and negative sides . These results affirmed that the catalyst is stable up to 315 °C.…”

“…Additional bands at 881 and 578 cm −1 are assigned to the bending vibrations of S−O. The spectrum also shows a broad band around 2100 to 3600 cm −1 due to OH stretching absorption of the acidic groups proving the successful preparation of the catalyst …”

“…The versatility of these compounds led to exploit various methods for the synthesis of them in which three‐component reaction of aldehydes, malononitrile and 2‐aminobenzimidazole and/or 3‐amino[1,2,4]triazole as amine sources, is a short‐route and time‐saving method. For this purpose, a variety of catalysts and conditions have been reported …”

Microwave Assisted Synthesis of Pyrimidines in Ionic Liquid and Their Potency as Non‐Classical Malarial Antifolates

“…Across the list of various heterocyclic motifs, pyrazole derivatives have proved their significance in therapeutics by owning various biological activities such as antimicrobial , anti‐inflammatory , antifungal , antitumor, antiviral , and antimalarial activities. Another class of fused heterocyclic entity is bridge‐headed nitrogen containing triazolopyrimidine derivatives, resembling purine, and has remarkable therapeutic and pharmacological applications . They are functional therapeutics, especially for the treatment and prevention of cardiovascular diseases, also known to posses smooth muscles cell growth inhibiting efficacy, are efficient analgesics, anti‐inflammatory agents and are also found potent antimalarial agents .…”

“…They are functional therapeutics, especially for the treatment and prevention of cardiovascular diseases, also known to posses smooth muscles cell growth inhibiting efficacy, are efficient analgesics, anti‐inflammatory agents and are also found potent antimalarial agents . Literature studies revealed the antimalarial potency of 1,3‐diarylpyrazole scaffold as well as the efficacy of triazolopyrimidine nucleus as an antimalarial entity depicted in Fig. .…”