2024
DOI: 10.1021/acs.joc.4c00728
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Organocatalytic Csp2–O Amination of Quinolin-4(1H)-ones with 3-Alkynyl-3-hydroxyisoindolinones

Tingting Huang,
Chenxiao Qian,
Pengfei Li

Abstract: The Brønsted acid catalytic C sp2 −O amination of quinolin-4(1H)-ones with 3-alkynyl-3-hydroxyisoindolinones as animation reagents has been developed. The cascade dehydration/conjugate addition/intramolecular annulation/ring-opening reaction proceeded smoothly to afford a broad scope of aminated products with high efficiency. Furthermore, the enantioselective construction of C sp2 −N atropisomers was also investigated in the presence of chiral phosphoric acid. Importantly, this work not only realized the organ… Show more

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